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Protein

Inter alpha-trypsin inhibitor, heavy chain 4

Gene

Itih4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processAcute phase

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Inter alpha-trypsin inhibitor, heavy chain 4
Short name:
ITI heavy chain H4
Short name:
ITI-HC4
Short name:
Inter-alpha-inhibitor heavy chain 4
Gene namesi
Name:Itih4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109536 Itih4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000042086429 – 942Inter alpha-trypsin inhibitor, heavy chain 4Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi517N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi577N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi732O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi761 ↔ 937By similarity
Glycosylationi874N-linked (GlcNAc...) asparagine2 Publications1

Post-translational modificationi

May be O-glycosylated (By similarity). N-glycosylated.By similarity2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6X935
PeptideAtlasiA6X935
PRIDEiA6X935

PTM databases

GlyConnecti786
iPTMnetiA6X935
PhosphoSitePlusiA6X935

Expressioni

Tissue specificityi

Highly expressed in liver. Weak expression in lung and heart.1 Publication

Developmental stagei

During mid-embryonic gestation, expressed abundantly in liver, less in heart and brain. Highest expression at day 14.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000021922
ExpressionAtlasiA6X935 baseline and differential
GenevisibleiA6X935 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain).1 Publication

Protein-protein interaction databases

BioGridi200839, 1 interactor
IntActiA6X935, 5 interactors
MINTiA6X935
STRINGi10090.ENSMUSP00000006703

Structurei

3D structure databases

ProteinModelPortaliA6X935
SMRiA6X935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 148VITPROSITE-ProRule annotationAdd BLAST120
Domaini274 – 457VWFAPROSITE-ProRule annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili552 – 586Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi662 – 753Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
GeneTreeiENSGT00550000074468
HOGENOMiHOG000000680
HOVERGENiHBG057734
InParanoidiA6X935
OMAiESTFMTN
OrthoDBiEOG091G01HF
PhylomeDBiA6X935

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6X935-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPAPAHMW NLVLFLPSLL AVLPTTTAEK NGIDIYSLTV DSRVSSRFAH
60 70 80 90 100
TVVTSRVVNR ADAVQEATFQ VELPRKAFIT NFSMIIDGVT YPGVVKEKAE
110 120 130 140 150
AQKQYSAAVG RGESAGIVKT TGRQTEKFEV SVNVAPGSKI TFELIYQELL
160 170 180 190 200
QRRLGMYELL LKVRPQQLVK HLQMDIYIFE PQGISILETE STFMTPELAN
210 220 230 240 250
ALTTSQNKTK AHIRFKPTLS QQQKSQSEQD TVLNGDFIVR YDVNRSDSGG
260 270 280 290 300
SIQIEEGYFV HHFAPENLPT MSKNVIFVID KSGSMSGKKI QQTREALVKI
310 320 330 340 350
LKDLSPQDQF NLIEFSGEAN QWKQSLVQAT EENLNKAVNY ASRIRAHGGT
360 370 380 390 400
NINNAVLLAV ELLDRSNQAE LLPSKSVSLI ILLTDGDPTV GETNPTIIQN
410 420 430 440 450
NVREAINGQY SLFCLGFGFD VNYPFLEKMA LDNGGLARRI YEDSDSALQL
460 470 480 490 500
QDFYHEVANP LLSSVAFEYP SDAVEEVTRY KFQHHFKGSE MVVAGKLQDQ
510 520 530 540 550
GPDVLLAKVS GQMHMQNITF QTEASVAQQE KEFKSPKYIF HNFMERLWAL
560 570 580 590 600
LTIQQQLEQR ISASGAELEA LEAQVLNLSL KYNFVTPLTH MVVTKPEGQE
610 620 630 640 650
QFQVAEKPVE VGDGMQRLPL AAQAHPFRPP VRGSKLMTVL KGSRSQIPRL
660 670 680 690 700
GDAVRASRQY IPPGFPGPPG PPGFPAPPGP PGFPAPPGPP LASGSDFSLQ
710 720 730 740 750
PSYERMLSLP SVAAQYPADP HLVVTEKSKE STIPEESPNP DHPQVPTITL
760 770 780 790 800
PLPGSSVDQL CVDILHSEKP MKLFVDPSQG LEVTGKYENT GFSWLEVTIQ
810 820 830 840 850
KPHLQVHATP ERLVVTRGRK NTEYKWKKTL FSVLPGLKMT MNMMGLLQLS
860 870 880 890 900
GPDKVTIGLL SLDDPQRGLM LLLNDTQHFS NNVKGELGQF YRDIVWEPPV
910 920 930 940
EPDNTKRTVK VQGVDYLATR ELKLSYQEGF PGAEISCWTV EI
Length:942
Mass (Da):104,659
Last modified:January 9, 2013 - v2
Checksum:i5D613FFBAB52A608
GO
Isoform 2 (identifier: A6X935-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     741-779: Missing.

Show »
Length:903
Mass (Da):100,395
Checksum:iE897BFE3CAEEF508
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti491Missing in BAC34032 (PubMed:16141072).Curated1
Sequence conflicti517N → H in BAC34032 (PubMed:16141072).Curated1
Sequence conflicti650L → R in AAC25786 (PubMed:9602042).Curated1
Sequence conflicti650L → R in AAH92258 (PubMed:15489334).Curated1
Sequence conflicti650L → R in AAH94457 (PubMed:15489334).Curated1
Sequence conflicti650L → R in AAH16500 (PubMed:15489334).Curated1
Sequence conflicti713Missing in BAB23649 (PubMed:16141072).Curated1
Sequence conflicti713Missing in AAH16500 (PubMed:15489334).Curated1
Sequence conflicti713Missing in AAH92258 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044763741 – 779Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023919 mRNA Translation: AAC25786.1
AK004893 mRNA Translation: BAB23649.1
AK050016 mRNA Translation: BAC34032.1
AK050270 mRNA Translation: BAC34155.1
CT025528 Genomic DNA Translation: CAO78004.1
CT025528 Genomic DNA Translation: CAO78005.1
CH466573 Genomic DNA Translation: EDL24772.1
BC016500 mRNA Translation: AAH16500.1
BC092258 mRNA Translation: AAH92258.1
BC094457 mRNA Translation: AAH94457.1
CCDSiCCDS26901.1 [A6X935-1]
RefSeqiNP_001152771.1, NM_001159299.2
NP_001276561.1, NM_001289632.1
NP_001276562.1, NM_001289633.1
NP_061216.2, NM_018746.4 [A6X935-1]
UniGeneiMm.34819

Genome annotation databases

EnsembliENSMUST00000120269; ENSMUSP00000112798; ENSMUSG00000021922 [A6X935-1]
GeneIDi16427
KEGGimmu:16427
UCSCiuc007svv.3 mouse [A6X935-1]
uc007svx.3 mouse [A6X935-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiITIH4_MOUSE
AccessioniPrimary (citable) accession number: A6X935
Secondary accession number(s): O54882
, Q505P8, Q8C7G9, Q8C7K5, Q91W60, Q9DBK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: January 9, 2013
Last modified: April 25, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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