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A6X7T0 (A6X7T0_OCHA4) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate carboxylase PIRNR PIRNR001594

EC=6.4.1.1 PIRNR PIRNR001594
Gene names
Ordered Locus Names:Oant_4597 EMBL ABS17284.1
Encoded onPlasmid pOANT01 Ref.1 EMBL ABS17284.1
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP] EMBL ABS17284.1
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum

Protein attributes

Sequence length1157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second By similarity. PIRNR PIRNR001594

Catalytic activity

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate. PIRNR PIRNR001594

Cofactor

Biotin By similarity. PIRNR PIRNR001594

Sequences

Sequence LengthMass (Da)Tools
A6X7T0 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 40ABE3A3A4046F5F

FASTA1,157127,338
        10         20         30         40         50         60 
MSITKILVAN RSEIAIRVFR AANELGIKTV AIWAEEDKLS LHRFKADESY QVGRGPHLAK 

        70         80         90        100        110        120 
DMGPIESYLS IEEVIRVAKL SGADAIHPGY GLLSESPEFV EACNKAGITF IGPTADTMRQ 

       130        140        150        160        170        180 
LGNKVAARNL AISVGVPVVP ATDPLPDDMA EVERMAEEIG YPVMLKASWG GGGRGMRAIR 

       190        200        210        220        230        240 
KKEDLAREVT EAKREAKAAF GKDEVYLEKL VERARHVESQ ILGDTHGNVV HLFERDCSIQ 

       250        260        270        280        290        300 
RRNQKVVERA PAPYLSEAQR QELASYSLKI AGATNYIGAG TVEYLMDADT GKFYFIEVNP 

       310        320        330        340        350        360 
RIQVEHTVTE VVTGIDIVKA QIHILEGAAI GTPESGVPRQ EDIRLNGHAL QCRITTEDPE 

       370        380        390        400        410        420 
HNFIPDYGRI TAYRSASGFG IRLDGGTSYT GAVITRYYDP LLVKVTAWAP RPDEAINRMD 

       430        440        450        460        470        480 
RALREFRIRG VATNLTFLEA IIGHDSFRNN TYTTRFIDST PELFAQVKRQ DRATKLLTYL 

       490        500        510        520        530        540 
ADVTVNGHPE TKGRAIPSDK AAKPIVPYID APTPDGTKQL LDKLGPKGFA DWMRNEKRVL 

       550        560        570        580        590        600 
VTDTTMRDGH QSLLATRVRT HDIARVASAY AKALPQLLSL ECWGGATFDV SMRFLTEDPW 

       610        620        630        640        650        660 
ERLALIREGA PNLLLQMLLR GANGVGYKNY PDNVVKYFVR QAAKGGIDLF RVFDCLNWVE 

       670        680        690        700        710        720 
NMRVSMDAIS EENKLCEAAI CYTGDILNSA RPKYDLKYYT NLAQELERAG AHIIAVKDMA 

       730        740        750        760        770        780 
GLLKPAAAKV LFKALREETG LPIHFHTHDT SGIAAATVLA AVDAGVDAVD AAMDAFSGNT 

       790        800        810        820        830        840 
SQPCLGSIVE ALAGSERDTG LDTEWIRRIS FYWEAVRNQY AAFESDLKGP ASEVYLHEMP 

       850        860        870        880        890        900 
GGQFTNLKEQ ARSLGLESRW HEVAQAYADA NRMFGDIVKV TPSSKVVGDM ALMMVSQDLT 

       910        920        930        940        950        960 
VADVQNPERE VSFPESVVSM LKGDLGQSPG GWPEALQKKA LKGEAPYTVR PGSLLADADL 

       970        980        990       1000       1010       1020 
DAERKAIETK LERKVDDFEF ASYLMYPKVF TDFALTAETY GPVSVLPTHA YFYGMEDGEE 

      1030       1040       1050       1060       1070       1080 
LFADIERGKT LVIVNQASSG VDDKGMVTVF FEINGQPRRI KVPDRTHGAS GFAVRRKAEP 

      1090       1100       1110       1120       1130       1140 
GNASHVGAPM PGVISRVFVN QGQEVKAGDV LLSIEAMKME TALHAERDGK IAEVLVRPGD 

      1150 
QIDAKDLLVI FVIQPQN 

« Hide

References

[1]"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000760 Genomic DNA. Translation: ABS17284.1.
RefSeqYP_001373113.1. NC_009669.1.

3D structure databases

ProteinModelPortalA6X7T0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439375.Oant_4597.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS17284; ABS17284; Oant_4597.
GeneID5382991.
KEGGoan:Oant_4597.
PATRIC20474621. VBIOchAnt73124_4770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1038.
HOGENOMHOG000282801.
KOK01958.
OMAGPTADTM.
OrthoDBEOG6CVV6Z.

Enzyme and pathway databases

BioCycOANT439375:GJIT-4672-MONOMER.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
3.20.20.70. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR003379. Carboxylase_cons_dom.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR009057. Homeodomain-like.
IPR016185. PreATP-grasp_dom.
IPR000891. PYR_CT.
IPR005930. Pyruv_COase.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERPTHR18866:SF10. PTHR18866:SF10. 1 hit.
PfamPF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view]
PIRSFPIRSF001594. Pyruv_carbox. 1 hit.
SMARTSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01235. pyruv_carbox. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6X7T0_OCHA4
AccessionPrimary (citable) accession number: A6X7T0
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)