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Protein

Pyruvate carboxylase

Gene

Oant_4597

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.UniRule annotation

Catalytic activityi

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.UniRule annotation

Cofactori

biotinUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124ATPUniRule annotation1
Binding sitei208ATPUniRule annotation1
Active sitei301UniRule annotation1
Metal bindingi548Divalent metal cationUniRule annotation1
Binding sitei620SubstrateUniRule annotation1
Metal bindingi717Divalent metal cation; via carbamate groupUniRule annotation1
Metal bindingi746Divalent metal cationUniRule annotation1
Metal bindingi748Divalent metal cationUniRule annotation1
Binding sitei881SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
LigandATP-bindingUniRule annotation, BiotinUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

BioCyciOANT439375:G1G9F-4814-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Oant_4597Imported
Encoded oniPlasmid pOANT01Imported
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)Imported
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
Proteomesi
  • UP000002301 Componenti: Plasmid pOANT01

Structurei

3D structure databases

ProteinModelPortaliA6X7T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 462Biotin carboxylationInterPro annotationAdd BLAST461
Domaini128 – 326ATP-graspInterPro annotationAdd BLAST199
Domaini539 – 807Pyruvate carboxyltransferaseInterPro annotationAdd BLAST269
Domaini1077 – 1152Lipoyl-bindingInterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili175 – 202Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000282801
KOiK01958
OMAiEFVDACN
OrthoDBiPOG091H02XZ

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit

Sequencei

Sequence statusi: Complete.

A6X7T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITKILVAN RSEIAIRVFR AANELGIKTV AIWAEEDKLS LHRFKADESY
60 70 80 90 100
QVGRGPHLAK DMGPIESYLS IEEVIRVAKL SGADAIHPGY GLLSESPEFV
110 120 130 140 150
EACNKAGITF IGPTADTMRQ LGNKVAARNL AISVGVPVVP ATDPLPDDMA
160 170 180 190 200
EVERMAEEIG YPVMLKASWG GGGRGMRAIR KKEDLAREVT EAKREAKAAF
210 220 230 240 250
GKDEVYLEKL VERARHVESQ ILGDTHGNVV HLFERDCSIQ RRNQKVVERA
260 270 280 290 300
PAPYLSEAQR QELASYSLKI AGATNYIGAG TVEYLMDADT GKFYFIEVNP
310 320 330 340 350
RIQVEHTVTE VVTGIDIVKA QIHILEGAAI GTPESGVPRQ EDIRLNGHAL
360 370 380 390 400
QCRITTEDPE HNFIPDYGRI TAYRSASGFG IRLDGGTSYT GAVITRYYDP
410 420 430 440 450
LLVKVTAWAP RPDEAINRMD RALREFRIRG VATNLTFLEA IIGHDSFRNN
460 470 480 490 500
TYTTRFIDST PELFAQVKRQ DRATKLLTYL ADVTVNGHPE TKGRAIPSDK
510 520 530 540 550
AAKPIVPYID APTPDGTKQL LDKLGPKGFA DWMRNEKRVL VTDTTMRDGH
560 570 580 590 600
QSLLATRVRT HDIARVASAY AKALPQLLSL ECWGGATFDV SMRFLTEDPW
610 620 630 640 650
ERLALIREGA PNLLLQMLLR GANGVGYKNY PDNVVKYFVR QAAKGGIDLF
660 670 680 690 700
RVFDCLNWVE NMRVSMDAIS EENKLCEAAI CYTGDILNSA RPKYDLKYYT
710 720 730 740 750
NLAQELERAG AHIIAVKDMA GLLKPAAAKV LFKALREETG LPIHFHTHDT
760 770 780 790 800
SGIAAATVLA AVDAGVDAVD AAMDAFSGNT SQPCLGSIVE ALAGSERDTG
810 820 830 840 850
LDTEWIRRIS FYWEAVRNQY AAFESDLKGP ASEVYLHEMP GGQFTNLKEQ
860 870 880 890 900
ARSLGLESRW HEVAQAYADA NRMFGDIVKV TPSSKVVGDM ALMMVSQDLT
910 920 930 940 950
VADVQNPERE VSFPESVVSM LKGDLGQSPG GWPEALQKKA LKGEAPYTVR
960 970 980 990 1000
PGSLLADADL DAERKAIETK LERKVDDFEF ASYLMYPKVF TDFALTAETY
1010 1020 1030 1040 1050
GPVSVLPTHA YFYGMEDGEE LFADIERGKT LVIVNQASSG VDDKGMVTVF
1060 1070 1080 1090 1100
FEINGQPRRI KVPDRTHGAS GFAVRRKAEP GNASHVGAPM PGVISRVFVN
1110 1120 1130 1140 1150
QGQEVKAGDV LLSIEAMKME TALHAERDGK IAEVLVRPGD QIDAKDLLVI

FVIQPQN
Length:1,157
Mass (Da):127,338
Last modified:August 21, 2007 - v1
Checksum:i40ABE3A3A4046F5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000760 Genomic DNA Translation: ABS17284.1
RefSeqiWP_011982815.1, NC_009669.1

Genome annotation databases

EnsemblBacteriaiABS17284; ABS17284; Oant_4597
GeneIDi5382991
KEGGioan:Oant_4597
PATRICifig|439375.7.peg.4770

Similar proteinsi

Entry informationi

Entry nameiA6X7T0_OCHA4
AccessioniPrimary (citable) accession number: A6X7T0
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported, Reference proteomeImported

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