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A6X7T0

- A6X7T0_OCHA4

UniProt

A6X7T0 - A6X7T0_OCHA4

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Protein

Pyruvate carboxylase

Gene

Oant_4597

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.UniRule annotation

Catalytic activityi

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.UniRule annotation

Cofactori

Biotin.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. biotin carboxylase activity Source: InterPro
  3. DNA binding Source: InterPro
  4. metal ion binding Source: InterPro
  5. pyruvate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, BiotinUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

BioCyciOANT439375:GJIT-4672-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Oant_4597Imported
Encoded oniPlasmid pOANT01Imported
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)Imported
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Plasmid pOANT01

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_4597.

Structurei

3D structure databases

ProteinModelPortaliA6X7T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1038.
HOGENOMiHOG000282801.
KOiK01958.
OMAiGPTADTM.
OrthoDBiEOG6CVV6Z.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.20.20.70. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR003379. Carboxylase_cons_dom.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR009057. Homeodomain-like.
IPR016185. PreATP-grasp_dom.
IPR000891. PYR_CT.
IPR005930. Pyruv_COase.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR18866:SF10. PTHR18866:SF10. 1 hit.
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view]
PIRSFiPIRSF001594. Pyruv_carbox. 1 hit.
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01235. pyruv_carbox. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6X7T0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSITKILVAN RSEIAIRVFR AANELGIKTV AIWAEEDKLS LHRFKADESY
60 70 80 90 100
QVGRGPHLAK DMGPIESYLS IEEVIRVAKL SGADAIHPGY GLLSESPEFV
110 120 130 140 150
EACNKAGITF IGPTADTMRQ LGNKVAARNL AISVGVPVVP ATDPLPDDMA
160 170 180 190 200
EVERMAEEIG YPVMLKASWG GGGRGMRAIR KKEDLAREVT EAKREAKAAF
210 220 230 240 250
GKDEVYLEKL VERARHVESQ ILGDTHGNVV HLFERDCSIQ RRNQKVVERA
260 270 280 290 300
PAPYLSEAQR QELASYSLKI AGATNYIGAG TVEYLMDADT GKFYFIEVNP
310 320 330 340 350
RIQVEHTVTE VVTGIDIVKA QIHILEGAAI GTPESGVPRQ EDIRLNGHAL
360 370 380 390 400
QCRITTEDPE HNFIPDYGRI TAYRSASGFG IRLDGGTSYT GAVITRYYDP
410 420 430 440 450
LLVKVTAWAP RPDEAINRMD RALREFRIRG VATNLTFLEA IIGHDSFRNN
460 470 480 490 500
TYTTRFIDST PELFAQVKRQ DRATKLLTYL ADVTVNGHPE TKGRAIPSDK
510 520 530 540 550
AAKPIVPYID APTPDGTKQL LDKLGPKGFA DWMRNEKRVL VTDTTMRDGH
560 570 580 590 600
QSLLATRVRT HDIARVASAY AKALPQLLSL ECWGGATFDV SMRFLTEDPW
610 620 630 640 650
ERLALIREGA PNLLLQMLLR GANGVGYKNY PDNVVKYFVR QAAKGGIDLF
660 670 680 690 700
RVFDCLNWVE NMRVSMDAIS EENKLCEAAI CYTGDILNSA RPKYDLKYYT
710 720 730 740 750
NLAQELERAG AHIIAVKDMA GLLKPAAAKV LFKALREETG LPIHFHTHDT
760 770 780 790 800
SGIAAATVLA AVDAGVDAVD AAMDAFSGNT SQPCLGSIVE ALAGSERDTG
810 820 830 840 850
LDTEWIRRIS FYWEAVRNQY AAFESDLKGP ASEVYLHEMP GGQFTNLKEQ
860 870 880 890 900
ARSLGLESRW HEVAQAYADA NRMFGDIVKV TPSSKVVGDM ALMMVSQDLT
910 920 930 940 950
VADVQNPERE VSFPESVVSM LKGDLGQSPG GWPEALQKKA LKGEAPYTVR
960 970 980 990 1000
PGSLLADADL DAERKAIETK LERKVDDFEF ASYLMYPKVF TDFALTAETY
1010 1020 1030 1040 1050
GPVSVLPTHA YFYGMEDGEE LFADIERGKT LVIVNQASSG VDDKGMVTVF
1060 1070 1080 1090 1100
FEINGQPRRI KVPDRTHGAS GFAVRRKAEP GNASHVGAPM PGVISRVFVN
1110 1120 1130 1140 1150
QGQEVKAGDV LLSIEAMKME TALHAERDGK IAEVLVRPGD QIDAKDLLVI

FVIQPQN
Length:1,157
Mass (Da):127,338
Last modified:August 21, 2007 - v1
Checksum:i40ABE3A3A4046F5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000760 Genomic DNA. Translation: ABS17284.1.
RefSeqiYP_001373113.1. NC_009669.1.

Genome annotation databases

EnsemblBacteriaiABS17284; ABS17284; Oant_4597.
GeneIDi5382991.
KEGGioan:Oant_4597.
PATRICi20474621. VBIOchAnt73124_4770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000760 Genomic DNA. Translation: ABS17284.1 .
RefSeqi YP_001373113.1. NC_009669.1.

3D structure databases

ProteinModelPortali A6X7T0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_4597.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS17284 ; ABS17284 ; Oant_4597 .
GeneIDi 5382991.
KEGGi oan:Oant_4597.
PATRICi 20474621. VBIOchAnt73124_4770.

Phylogenomic databases

eggNOGi COG1038.
HOGENOMi HOG000282801.
KOi K01958.
OMAi GPTADTM.
OrthoDBi EOG6CVV6Z.

Enzyme and pathway databases

BioCyci OANT439375:GJIT-4672-MONOMER.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
3.20.20.70. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR003379. Carboxylase_cons_dom.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR009057. Homeodomain-like.
IPR016185. PreATP-grasp_dom.
IPR000891. PYR_CT.
IPR005930. Pyruv_COase.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
PANTHERi PTHR18866:SF10. PTHR18866:SF10. 1 hit.
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001594. Pyruv_carbox. 1 hit.
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01235. pyruv_carbox. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiA6X7T0_OCHA4
AccessioniPrimary (citable) accession number: A6X7T0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported, Reference proteomeImported

External Data

Dasty 3