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A6X7T0

- A6X7T0_OCHA4

UniProt

A6X7T0 - A6X7T0_OCHA4

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Protein
Pyruvate carboxylase
Gene
Oant_4597
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second By similarity.UniRule annotation

Catalytic activityi

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.UniRule annotation

Cofactori

Biotin By similarity.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. biotin carboxylase activity Source: InterPro
  4. metal ion binding Source: InterPro
  5. pyruvate carboxylase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, BiotinUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

BioCyciOANT439375:GJIT-4672-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Oant_4597Imported
Encoded oniPlasmid pOANT01Imported
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)Imported
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Plasmid pOANT01

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_4597.

Structurei

3D structure databases

ProteinModelPortaliA6X7T0.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1038.
HOGENOMiHOG000282801.
KOiK01958.
OMAiGPTADTM.
OrthoDBiEOG6CVV6Z.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.20.20.70. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR003379. Carboxylase_cons_dom.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR009057. Homeodomain-like.
IPR016185. PreATP-grasp_dom.
IPR000891. PYR_CT.
IPR005930. Pyruv_COase.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR18866:SF10. PTHR18866:SF10. 1 hit.
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view]
PIRSFiPIRSF001594. Pyruv_carbox. 1 hit.
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01235. pyruv_carbox. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6X7T0-1 [UniParc]FASTAAdd to Basket

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MSITKILVAN RSEIAIRVFR AANELGIKTV AIWAEEDKLS LHRFKADESY     50
QVGRGPHLAK DMGPIESYLS IEEVIRVAKL SGADAIHPGY GLLSESPEFV 100
EACNKAGITF IGPTADTMRQ LGNKVAARNL AISVGVPVVP ATDPLPDDMA 150
EVERMAEEIG YPVMLKASWG GGGRGMRAIR KKEDLAREVT EAKREAKAAF 200
GKDEVYLEKL VERARHVESQ ILGDTHGNVV HLFERDCSIQ RRNQKVVERA 250
PAPYLSEAQR QELASYSLKI AGATNYIGAG TVEYLMDADT GKFYFIEVNP 300
RIQVEHTVTE VVTGIDIVKA QIHILEGAAI GTPESGVPRQ EDIRLNGHAL 350
QCRITTEDPE HNFIPDYGRI TAYRSASGFG IRLDGGTSYT GAVITRYYDP 400
LLVKVTAWAP RPDEAINRMD RALREFRIRG VATNLTFLEA IIGHDSFRNN 450
TYTTRFIDST PELFAQVKRQ DRATKLLTYL ADVTVNGHPE TKGRAIPSDK 500
AAKPIVPYID APTPDGTKQL LDKLGPKGFA DWMRNEKRVL VTDTTMRDGH 550
QSLLATRVRT HDIARVASAY AKALPQLLSL ECWGGATFDV SMRFLTEDPW 600
ERLALIREGA PNLLLQMLLR GANGVGYKNY PDNVVKYFVR QAAKGGIDLF 650
RVFDCLNWVE NMRVSMDAIS EENKLCEAAI CYTGDILNSA RPKYDLKYYT 700
NLAQELERAG AHIIAVKDMA GLLKPAAAKV LFKALREETG LPIHFHTHDT 750
SGIAAATVLA AVDAGVDAVD AAMDAFSGNT SQPCLGSIVE ALAGSERDTG 800
LDTEWIRRIS FYWEAVRNQY AAFESDLKGP ASEVYLHEMP GGQFTNLKEQ 850
ARSLGLESRW HEVAQAYADA NRMFGDIVKV TPSSKVVGDM ALMMVSQDLT 900
VADVQNPERE VSFPESVVSM LKGDLGQSPG GWPEALQKKA LKGEAPYTVR 950
PGSLLADADL DAERKAIETK LERKVDDFEF ASYLMYPKVF TDFALTAETY 1000
GPVSVLPTHA YFYGMEDGEE LFADIERGKT LVIVNQASSG VDDKGMVTVF 1050
FEINGQPRRI KVPDRTHGAS GFAVRRKAEP GNASHVGAPM PGVISRVFVN 1100
QGQEVKAGDV LLSIEAMKME TALHAERDGK IAEVLVRPGD QIDAKDLLVI 1150
FVIQPQN 1157
Length:1,157
Mass (Da):127,338
Last modified:August 21, 2007 - v1
Checksum:i40ABE3A3A4046F5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000760 Genomic DNA. Translation: ABS17284.1.
RefSeqiYP_001373113.1. NC_009669.1.

Genome annotation databases

EnsemblBacteriaiABS17284; ABS17284; Oant_4597.
GeneIDi5382991.
KEGGioan:Oant_4597.
PATRICi20474621. VBIOchAnt73124_4770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000760 Genomic DNA. Translation: ABS17284.1 .
RefSeqi YP_001373113.1. NC_009669.1.

3D structure databases

ProteinModelPortali A6X7T0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 439375.Oant_4597.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS17284 ; ABS17284 ; Oant_4597 .
GeneIDi 5382991.
KEGGi oan:Oant_4597.
PATRICi 20474621. VBIOchAnt73124_4770.

Phylogenomic databases

eggNOGi COG1038.
HOGENOMi HOG000282801.
KOi K01958.
OMAi GPTADTM.
OrthoDBi EOG6CVV6Z.

Enzyme and pathway databases

BioCyci OANT439375:GJIT-4672-MONOMER.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
3.20.20.70. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR003379. Carboxylase_cons_dom.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR009057. Homeodomain-like.
IPR016185. PreATP-grasp_dom.
IPR000891. PYR_CT.
IPR005930. Pyruv_COase.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
PANTHERi PTHR18866:SF10. PTHR18866:SF10. 1 hit.
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001594. Pyruv_carbox. 1 hit.
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01235. pyruv_carbox. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.
    Plasmid: pOANT01

Entry informationi

Entry nameiA6X7T0_OCHA4
AccessioniPrimary (citable) accession number: A6X7T0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported

External Data

Dasty 3

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