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A6X7T0

- A6X7T0_OCHA4

UniProt

A6X7T0 - A6X7T0_OCHA4

Protein

Pyruvate carboxylase

Gene

Oant_4597

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.UniRule annotation

    Catalytic activityi

    ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.UniRule annotation

    Cofactori

    Biotin.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. biotin carboxylase activity Source: InterPro
    3. DNA binding Source: InterPro
    4. metal ion binding Source: InterPro
    5. pyruvate carboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: InterPro

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, BiotinUniRule annotation, Nucleotide-binding, PyruvateImported

    Enzyme and pathway databases

    BioCyciOANT439375:GJIT-4672-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Oant_4597Imported
    Encoded oniPlasmid pOANT01Imported
    OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)Imported
    Taxonomic identifieri439375 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
    ProteomesiUP000002301: Plasmid pOANT01

    Interactioni

    Protein-protein interaction databases

    STRINGi439375.Oant_4597.

    Structurei

    3D structure databases

    ProteinModelPortaliA6X7T0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1038.
    HOGENOMiHOG000282801.
    KOiK01958.
    OMAiGPTADTM.
    OrthoDBiEOG6CVV6Z.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    3.20.20.70. 1 hit.
    3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR001882. Biotin_BS.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR003379. Carboxylase_cons_dom.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR009057. Homeodomain-like.
    IPR016185. PreATP-grasp_dom.
    IPR000891. PYR_CT.
    IPR005930. Pyruv_COase.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PANTHERiPTHR18866:SF10. PTHR18866:SF10. 1 hit.
    PfamiPF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    PF00682. HMGL-like. 1 hit.
    PF02436. PYC_OADA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001594. Pyruv_carbox. 1 hit.
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01235. pyruv_carbox. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00188. BIOTIN. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6X7T0-1 [UniParc]FASTAAdd to Basket

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    MSITKILVAN RSEIAIRVFR AANELGIKTV AIWAEEDKLS LHRFKADESY     50
    QVGRGPHLAK DMGPIESYLS IEEVIRVAKL SGADAIHPGY GLLSESPEFV 100
    EACNKAGITF IGPTADTMRQ LGNKVAARNL AISVGVPVVP ATDPLPDDMA 150
    EVERMAEEIG YPVMLKASWG GGGRGMRAIR KKEDLAREVT EAKREAKAAF 200
    GKDEVYLEKL VERARHVESQ ILGDTHGNVV HLFERDCSIQ RRNQKVVERA 250
    PAPYLSEAQR QELASYSLKI AGATNYIGAG TVEYLMDADT GKFYFIEVNP 300
    RIQVEHTVTE VVTGIDIVKA QIHILEGAAI GTPESGVPRQ EDIRLNGHAL 350
    QCRITTEDPE HNFIPDYGRI TAYRSASGFG IRLDGGTSYT GAVITRYYDP 400
    LLVKVTAWAP RPDEAINRMD RALREFRIRG VATNLTFLEA IIGHDSFRNN 450
    TYTTRFIDST PELFAQVKRQ DRATKLLTYL ADVTVNGHPE TKGRAIPSDK 500
    AAKPIVPYID APTPDGTKQL LDKLGPKGFA DWMRNEKRVL VTDTTMRDGH 550
    QSLLATRVRT HDIARVASAY AKALPQLLSL ECWGGATFDV SMRFLTEDPW 600
    ERLALIREGA PNLLLQMLLR GANGVGYKNY PDNVVKYFVR QAAKGGIDLF 650
    RVFDCLNWVE NMRVSMDAIS EENKLCEAAI CYTGDILNSA RPKYDLKYYT 700
    NLAQELERAG AHIIAVKDMA GLLKPAAAKV LFKALREETG LPIHFHTHDT 750
    SGIAAATVLA AVDAGVDAVD AAMDAFSGNT SQPCLGSIVE ALAGSERDTG 800
    LDTEWIRRIS FYWEAVRNQY AAFESDLKGP ASEVYLHEMP GGQFTNLKEQ 850
    ARSLGLESRW HEVAQAYADA NRMFGDIVKV TPSSKVVGDM ALMMVSQDLT 900
    VADVQNPERE VSFPESVVSM LKGDLGQSPG GWPEALQKKA LKGEAPYTVR 950
    PGSLLADADL DAERKAIETK LERKVDDFEF ASYLMYPKVF TDFALTAETY 1000
    GPVSVLPTHA YFYGMEDGEE LFADIERGKT LVIVNQASSG VDDKGMVTVF 1050
    FEINGQPRRI KVPDRTHGAS GFAVRRKAEP GNASHVGAPM PGVISRVFVN 1100
    QGQEVKAGDV LLSIEAMKME TALHAERDGK IAEVLVRPGD QIDAKDLLVI 1150
    FVIQPQN 1157
    Length:1,157
    Mass (Da):127,338
    Last modified:August 21, 2007 - v1
    Checksum:i40ABE3A3A4046F5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000760 Genomic DNA. Translation: ABS17284.1.
    RefSeqiYP_001373113.1. NC_009669.1.

    Genome annotation databases

    EnsemblBacteriaiABS17284; ABS17284; Oant_4597.
    GeneIDi5382991.
    KEGGioan:Oant_4597.
    PATRICi20474621. VBIOchAnt73124_4770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000760 Genomic DNA. Translation: ABS17284.1 .
    RefSeqi YP_001373113.1. NC_009669.1.

    3D structure databases

    ProteinModelPortali A6X7T0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439375.Oant_4597.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS17284 ; ABS17284 ; Oant_4597 .
    GeneIDi 5382991.
    KEGGi oan:Oant_4597.
    PATRICi 20474621. VBIOchAnt73124_4770.

    Phylogenomic databases

    eggNOGi COG1038.
    HOGENOMi HOG000282801.
    KOi K01958.
    OMAi GPTADTM.
    OrthoDBi EOG6CVV6Z.

    Enzyme and pathway databases

    BioCyci OANT439375:GJIT-4672-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    3.20.20.70. 1 hit.
    3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR001882. Biotin_BS.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR003379. Carboxylase_cons_dom.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR009057. Homeodomain-like.
    IPR016185. PreATP-grasp_dom.
    IPR000891. PYR_CT.
    IPR005930. Pyruv_COase.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    PANTHERi PTHR18866:SF10. PTHR18866:SF10. 1 hit.
    Pfami PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    PF00682. HMGL-like. 1 hit.
    PF02436. PYC_OADA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001594. Pyruv_carbox. 1 hit.
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01235. pyruv_carbox. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00188. BIOTIN. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
      Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
      J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiA6X7T0_OCHA4
    AccessioniPrimary (citable) accession number: A6X7T0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, PlasmidImported, Reference proteomeImported

    External Data

    Dasty 3