Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot A6X798 (3HAO_OCHA4)

Last modified February 9, 2010. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO
Gene names
Ordered Locus Names: Oant_4402
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Hide | Top

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP MF_00825

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP MF_00825

Cofactor

Binds 2 Fe2+ ions per subunit By similarity. HAMAP MF_00825

Subunit structure

Homodimer By similarity. HAMAP MF_00825

Sequence similarities

Belongs to the 3-HAO family.

Hide | Top

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: HAMAP

ferrous iron binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1821823-hydroxyanthranilate 3,4-dioxygenase HAMAP MF_00825
PRO_0000309576

Sites

Metal binding501Iron 1; catalytic By similarity
Metal binding561Iron 1; catalytic By similarity
Metal binding961Iron 1; catalytic By similarity
Metal binding1261Iron 2 By similarity
Metal binding1291Iron 2 By similarity
Metal binding1631Iron 2 By similarity
Metal binding1661Iron 2 By similarity
Binding site461Dioxygen By similarity
Binding site561Substrate By similarity
Binding site1001Substrate By similarity
Binding site1111Substrate By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
A6X798-1 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 2E0B4D684E611342

FASTA18220,693
        10         20         30         40         50         60 
MTKLSAFNFQ KWIDEHKHLL KPPVGNQLVF KDADLMVTVV GGPNKRTDYH DDPVEEFFYQ 

        70         80         90        100        110        120 
LKGDMLLKLH DTSTGEFYDV PIREGDIFLL PAHIRHSPQR PQEGSIGLVI EPARPEGVLD 

       130        140        150        160        170        180 
AVEWYCFECS GLVHRAEVDL ESIVDDLPPL YAAFYNDEKL RTCPHCNTVH PGKNPPEGWV 


AL

« Hide

Hide | Top

References

[1]"Complete sequence of chromosome 2 of Ochrobactrum anthropi ATCC 49188."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000759 Genomic DNA. Translation: ABS17102.1.
RefSeqYP_001372931.1.

3D structure databases

SMRA6X798. Positions 1-173.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6X798.

Genome annotation databases

GeneID5382663.
GenomeReviewsGene locus Oant_4402 in contig CP000759_GR.
KEGGoan:Oant_4402.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG77058.
HOGENOMHBG341987.
OMARHSPQRP.

Family and domain databases

HAMAPMF_00825. 3_HAO.
[Tree]
InterProIPR010329. 3hydroanth_dOase.
IPR011051. Cupin_RmlC_type.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
Gene3DG3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Hide | Top

Entry information

Entry name3HAO_OCHA4
AccessionPrimary (citable) accession number: A6X798
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: February 9, 2010
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents