Reviewed,
UniProtKB/Swiss-Prot A6X798 (3HAO_OCHA4)
Last modified
February 9, 2010.
Version 20.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 3-hydroxyanthranilate 3,4-dioxygenase EC=1.13.11.6 Alternative name(s): 3-hydroxyanthranilic acid dioxygenase Short name=HAD 3-hydroxyanthranilate oxygenase Short name=3-HAO | ||
| Gene names |
| ||
| Organism | Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP] | ||
| Taxonomic identifier | 439375 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum |
Protein attributes
| Sequence length | 182 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP MF_00825 |
| Catalytic activity | 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP MF_00825 |
| Cofactor | Binds 2 Fe2+ ions per subunit By similarity. HAMAP MF_00825 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00825 |
| Sequence similarities | Belongs to the 3-HAO family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: HAMAP ferrous iron bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 182 | 182 | 3-hydroxyanthranilate 3,4-dioxygenase HAMAP MF_00825 | PRO_0000309576 | |||||
Sites | |||||||||
| Metal binding | 50 | 1 | Iron 1; catalytic By similarity | ||||||
| Metal binding | 56 | 1 | Iron 1; catalytic By similarity | ||||||
| Metal binding | 96 | 1 | Iron 1; catalytic By similarity | ||||||
| Metal binding | 126 | 1 | Iron 2 By similarity | ||||||
| Metal binding | 129 | 1 | Iron 2 By similarity | ||||||
| Metal binding | 163 | 1 | Iron 2 By similarity | ||||||
| Metal binding | 166 | 1 | Iron 2 By similarity | ||||||
| Binding site | 46 | 1 | Dioxygen By similarity | ||||||
| Binding site | 56 | 1 | Substrate By similarity | ||||||
| Binding site | 100 | 1 | Substrate By similarity | ||||||
| Binding site | 111 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of chromosome 2 of Ochrobactrum anthropi ATCC 49188." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000759 Genomic DNA. Translation: ABS17102.1. |
| RefSeq | YP_001372931.1. |
3D structure databases | |
| SMR | A6X798. Positions 1-173. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A6X798. |
Genome annotation databases | |
| GeneID | 5382663. |
| GenomeReviews | Gene locus Oant_4402 in contig CP000759_GR. |
| KEGG | oan:Oant_4402. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | NOG77058. |
| HOGENOM | HBG341987. |
| OMA | RHSPQRP. |
Family and domain databases | |
| HAMAP | MF_00825. 3_HAO. [Tree] |
| InterPro | IPR010329. 3hydroanth_dOase. IPR011051. Cupin_RmlC_type. IPR014710. RmlC-like_jellyroll. [Graphical view] |
| Gene3D | G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit. |
| Pfam | PF06052. 3-HAO. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03037. anthran_nbaC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | 3HAO_OCHA4 | ||||||||
| Accession | Primary (citable) accession number: A6X798 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


