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A6X792 (ASPD_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase

EC=1.4.1.21
Gene names
Name:nadX
Ordered Locus Names:Oant_4396
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Probable L-aspartate dehydrogenase HAMAP-Rule MF_01265
PRO_1000067309

Sites

Active site2211 By similarity
Binding site1251NAD; via amide nitrogen By similarity
Binding site1911NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A6X792 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 32BA43AEF0CCFC12

FASTA26827,854
        10         20         30         40         50         60 
MSVSETIVLV GWGAIGKRVA DLLAERKSSV RIGAVAVRDR SASRDRLPAG AVLIENPAEL 

        70         80         90        100        110        120 
AASGASLVVE AAGRPSVLPW GEAALSTGMD FAVSSTSAFV DDALFQRLKD AAAASGAKLI 

       130        140        150        160        170        180 
IPPGALGGID ALSAASRLSI ESVEHRIIKP AKAWAGTQAA QLVPLDEISE ATVFFTDTAR 

       190        200        210        220        230        240 
KAADAFPQNA NVAVITSLAG IGLDRTRVTL VADPAARLNT HEIIAEGDFG RMHLRFENGP 

       250        260 
LATNPKSSEM TALNLVRAIE NRVATTVI 

« Hide

References

[1]"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000759 Genomic DNA. Translation: ABS17096.1.
RefSeqYP_001372925.1. NC_009668.1.

3D structure databases

ProteinModelPortalA6X792.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439375.Oant_4396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS17096; ABS17096; Oant_4396.
GeneID5381939.
KEGGoan:Oant_4396.
PATRIC20474226. VBIOchAnt73124_4572.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000206326.
KOK06989.
OMAECAGHSA.
OrthoDBEOG6ND0JC.

Enzyme and pathway databases

BioCycOANT439375:GJIT-4469-MONOMER.
UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD_OCHA4
AccessionPrimary (citable) accession number: A6X792
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways