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A6X6W2 (HEMH_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Oant_4266
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Ferrochelatase HAMAP MF_00323
PRO_1000019332

Sites

Metal binding2201Iron By similarity
Metal binding3011Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A6X6W2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: CDFC184164C39D99

FASTA35040,051
        10         20         30         40         50         60 
MSEMDKVQEK PSQTTKTEVQ AKLPKVGVLL VNLGTPDGTS YGPMRRYLAE FLSDRRVIEW 

        70         80         90        100        110        120 
PRLIWYPILY GIVLNTRPKR SGKLYDRIWN REKNESPLRT YTRAQGEKLA TALADYPNVV 

       130        140        150        160        170        180 
VDWAMRYGQP SIESVTDRLL QQGCERIVMF PLYPQYSATT TATVNDKFFE ALMKKRFQPA 

       190        200        210        220        230        240 
VRIVPSYETE PVYIEALARS IEKHLETLSF KPEVVLASYH GIPKSYSDKG DPYRQQCLET 

       250        260        270        280        290        300 
SRLLQARLGL DDSQFRSTFQ SRFGPEEWLQ PYTDETVEEL AKHGVKSMAV LNPGFVADCL 

       310        320        330        340        350 
ETVDEIGNEA AEEFLENGGE SFSHIPCLND SEDGMKVIET LVRRELQGWV

« Hide

References

[1]"Complete sequence of chromosome 2 of Ochrobactrum anthropi ATCC 49188."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000759 Genomic DNA. Translation: ABS16966.1.
RefSeqYP_001372795.1. NC_009668.1.

3D structure databases

ProteinModelPortalA6X6W2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6X6W2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5381908.
GenomeReviewsGene locus Oant_4266 in contig CP000759_GR.
KEGGoan:Oant_4266.
PATRIC20473958. VBIOchAnt73124_4439.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycOANT439375:OANT_4266-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_OCHA4
AccessionPrimary (citable) accession number: A6X6W2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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