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A6X4Y3 (A6X4Y3_OCHA4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase PIRNR PIRNR000099
Short name=HDH PIRNR PIRNR000099
EC=1.1.1.23 PIRNR PIRNR000099
Gene names
Ordered Locus Names:Oant_3581
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP] EMBL ABS16287.1
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. SAAS SAAS001692 PIRNR PIRNR000099

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. SAAS SAAS001692 PIRNR PIRNR000099

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS001692

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. SAAS SAAS001692 PIRNR PIRNR000099

Sequence similarities

Belongs to the histidinol dehydrogenase family. RuleBase RU004175 PIRNR PIRNR000099

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3331Proton acceptor By similarity PIRSR PIRSR000099-1
Active site3341Proton acceptor By similarity PIRSR PIRSR000099-1

Sequences

Sequence LengthMass (Da)Tools
A6X4Y3 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 84F56CDE4A18114A

FASTA43846,920
        10         20         30         40         50         60 
MSDVSFHELA KLGDAARAEL LKRSETDLSG FIEKVKPIIE AVRTEGDAAL VRFARDLDKA 

        70         80         90        100        110        120 
EVDPANIKAT EAEFDAAFDK VEKDVIEAIQ FGIDNIRHFH EEQKPEAMWL KEMRPGAFAG 

       130        140        150        160        170        180 
DRFTPIRSVA LYIPRGKGAF PSVTMMTAVP AVVAGVPDLA IVTPPTPDGS VDAATLVAAR 

       190        200        210        220        230        240 
LAGVETVYKV GGAQAVAAVA YGTETVKPAL KIVGPGSPWV VAAKRLLGGV IDPGLPAGPS 

       250        260        270        280        290        300 
EAVIFADDTV KGGLAALDLL IEAEHGPDSS AWLVTHSRRV AEEALAALPD HWARMTEQRV 

       310        320        330        340        350        360 
GFSKTVLTGK YGGIVLTSSV EESYKFINDY APEHLELLST DPFAHLGHIT EAAEILMGPH 

       370        380        390        400        410        420 
TPVVIGNFGL GPNAVLPTSR WARTYGPLSV TDFVKRSSIG YVTASAYPEF AKHARTLARY 

       430 
EGFSSHENAV SEIRKDYL

« Hide

References

[1]"Complete sequence of chromosome 2 of Ochrobactrum anthropi ATCC 49188."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000759 Genomic DNA. Translation: ABS16287.1.
RefSeqYP_001372116.1. NC_009668.1.

3D structure databases

ProteinModelPortalA6X4Y3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6X4Y3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5381249.
GenomeReviewsGene locus Oant_3581 in contig CP000759_GR.
KEGGoan:Oant_3581.
PATRIC20472538. VBIOchAnt73124_3741.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHBG329596.
OMAKIVGPGS.
ProtClustDBPRK12447.

Enzyme and pathway databases

BioCycOANT439375:OANT_3581-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6X4Y3_OCHA4
AccessionPrimary (citable) accession number: A6X4Y3
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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