Reviewed, UniProtKB/Swiss-Prot A6X2G8 (BETB_OCHA4)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Oant_2710

Organism

Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]

Taxonomic identifier

439375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000047044
Regions
	Nucleotide binding	227 – 232	6	NAD By similarity
Sites
	Active site	249	1	By similarity
	Active site	283	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6X2G8-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 62AEA5F26C712CB9	FASTA	487	52,218
	10 20 30 40 50 60 MKAQPKASHF IGGAFVEDKT GKPSPVIYPA TGEEIARLYS ATPDVIEAAY AAALKAQGEW 70 80 90 100 110 120 AALKPVERGR ILRRTADILR EKNKKLSKLE TLDTGKALQE TLVADAASAA DALEFFGGII 130 140 150 160 170 180 SGFNGEFVEL GGSFAYTRRE ALGICVGIGA WNYPIQIAAW KSAPALAMGN AFIFKPSENT 190 200 210 220 230 240 PLSALALAEA YKEAGLPDGL FNVVQGFGDV GAALVNHRLT AKVSLTGSVP TGKRIMAQAG 250 260 270 280 290 300 EHLKHVTMEL GGKSPIIVFD DADIESAIGG AMLGNFYSTG QVCSNGTRVF VHKNLRERFV 310 320 330 340 350 360 ERLVERTRKI RIGDPLDEAT QMGPLVNRAQ RDKVLSYIEK GKAEGATLAC GGGVPKLQGF 370 380 390 400 410 420 DKGYFIEPTI FTDVTDDMTI AREEIFGPVM SVLEFSDEDE VIARANDTEF GLAAGVFTAD 430 440 450 460 470 480 IARGHRVIGQ IKAGTCWINA YNLTPVEVPF GGYKQSGIGR ENGIAALAHY SQIKTVYVEM GKVDSPY

References

[1]

"Complete sequence of chromosome 1 of Ochrobactrum anthropi ATCC 49188." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000758 Genomic DNA. Translation: ABS15422.1.
RefSeq	YP_001371251.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6X2G8.
Genome annotation databases
GeneID	5378475.
GenomeReviews	Gene locus Oant_2710 in contig CP000758_GR.
KEGG	oan:Oant_2710.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MCVLDFE.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_OCHA4

Accession

Primary (citable) accession number: A6X2G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)