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A6X2G8 (BETB_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:Oant_2710
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity. HAMAP-Rule MF_00804

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Cofactor

Binds 2 potassium ions per subunit By similarity. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Subunit structure

Dimer of dimers By similarity. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandMetal-binding
NAD
NADP
Potassium
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000047044

Regions

Nucleotide binding149 – 1524NAD/NADP By similarity
Nucleotide binding175 – 1784NAD/NADP By similarity
Nucleotide binding227 – 2326NAD/NADP By similarity

Sites

Active site1611Charge relay system By similarity
Active site2491Proton acceptor By similarity
Active site4611Charge relay system By similarity
Metal binding271Potassium 1; via carbonyl oxygen By similarity
Metal binding931Potassium 1 By similarity
Metal binding2431Potassium 2; via carbonyl oxygen By similarity
Metal binding4541Potassium 2; via carbonyl oxygen By similarity
Metal binding4571Potassium 2; via carbonyl oxygen By similarity
Binding site2081NAD/NADP; via amide nitrogen By similarity
Binding site2831NAD/NADP By similarity
Binding site3841NAD/NADP By similarity

Amino acid modifications

Modified residue2831Cysteine sulfenic acid (-SOH) By similarity

Sequences

Sequence LengthMass (Da)Tools
A6X2G8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 62AEA5F26C712CB9

FASTA48752,218
        10         20         30         40         50         60 
MKAQPKASHF IGGAFVEDKT GKPSPVIYPA TGEEIARLYS ATPDVIEAAY AAALKAQGEW 

        70         80         90        100        110        120 
AALKPVERGR ILRRTADILR EKNKKLSKLE TLDTGKALQE TLVADAASAA DALEFFGGII 

       130        140        150        160        170        180 
SGFNGEFVEL GGSFAYTRRE ALGICVGIGA WNYPIQIAAW KSAPALAMGN AFIFKPSENT 

       190        200        210        220        230        240 
PLSALALAEA YKEAGLPDGL FNVVQGFGDV GAALVNHRLT AKVSLTGSVP TGKRIMAQAG 

       250        260        270        280        290        300 
EHLKHVTMEL GGKSPIIVFD DADIESAIGG AMLGNFYSTG QVCSNGTRVF VHKNLRERFV 

       310        320        330        340        350        360 
ERLVERTRKI RIGDPLDEAT QMGPLVNRAQ RDKVLSYIEK GKAEGATLAC GGGVPKLQGF 

       370        380        390        400        410        420 
DKGYFIEPTI FTDVTDDMTI AREEIFGPVM SVLEFSDEDE VIARANDTEF GLAAGVFTAD 

       430        440        450        460        470        480 
IARGHRVIGQ IKAGTCWINA YNLTPVEVPF GGYKQSGIGR ENGIAALAHY SQIKTVYVEM 


GKVDSPY 

« Hide

References

[1]"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000758 Genomic DNA. Translation: ABS15422.1.
RefSeqYP_001371251.1. NC_009667.1.

3D structure databases

ProteinModelPortalA6X2G8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439375.Oant_2710.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS15422; ABS15422; Oant_2710.
GeneID5378475.
KEGGoan:Oant_2710.
PATRIC20470753. VBIOchAnt73124_2858.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAFEARVDI.
OrthoDBEOG6BS8QW.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycOANT439375:GJIT-2760-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_OCHA4
AccessionPrimary (citable) accession number: A6X2G8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways