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A6X2G8

- BETB_OCHA4

UniProt

A6X2G8 - BETB_OCHA4

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, Oant_2710
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Potassium 1; via carbonyl oxygen By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei161 – 1611Charge relay system By similarity
Binding sitei208 – 2081NAD/NADP; via amide nitrogen By similarity
Metal bindingi243 – 2431Potassium 2; via carbonyl oxygen By similarity
Active sitei249 – 2491Proton acceptor By similarity
Binding sitei283 – 2831NAD/NADP By similarity
Binding sitei384 – 3841NAD/NADP By similarity
Metal bindingi454 – 4541Potassium 2; via carbonyl oxygen By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Active sitei461 – 4611Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1524NAD/NADP By similarity
Nucleotide bindingi175 – 1784NAD/NADP By similarity
Nucleotide bindingi227 – 2326NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciOANT439375:GJIT-2760-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Oant_2710
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000047044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi439375.Oant_2710.

Structurei

3D structure databases

ProteinModelPortaliA6X2G8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCTDEMTI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6X2G8-1 [UniParc]FASTAAdd to Basket

« Hide

MKAQPKASHF IGGAFVEDKT GKPSPVIYPA TGEEIARLYS ATPDVIEAAY    50
AAALKAQGEW AALKPVERGR ILRRTADILR EKNKKLSKLE TLDTGKALQE 100
TLVADAASAA DALEFFGGII SGFNGEFVEL GGSFAYTRRE ALGICVGIGA 150
WNYPIQIAAW KSAPALAMGN AFIFKPSENT PLSALALAEA YKEAGLPDGL 200
FNVVQGFGDV GAALVNHRLT AKVSLTGSVP TGKRIMAQAG EHLKHVTMEL 250
GGKSPIIVFD DADIESAIGG AMLGNFYSTG QVCSNGTRVF VHKNLRERFV 300
ERLVERTRKI RIGDPLDEAT QMGPLVNRAQ RDKVLSYIEK GKAEGATLAC 350
GGGVPKLQGF DKGYFIEPTI FTDVTDDMTI AREEIFGPVM SVLEFSDEDE 400
VIARANDTEF GLAAGVFTAD IARGHRVIGQ IKAGTCWINA YNLTPVEVPF 450
GGYKQSGIGR ENGIAALAHY SQIKTVYVEM GKVDSPY 487
Length:487
Mass (Da):52,218
Last modified:August 21, 2007 - v1
Checksum:i62AEA5F26C712CB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS15422.1.
RefSeqiWP_012092478.1. NC_009667.1.
YP_001371251.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS15422; ABS15422; Oant_2710.
GeneIDi5378475.
KEGGioan:Oant_2710.
PATRICi20470753. VBIOchAnt73124_2858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS15422.1 .
RefSeqi WP_012092478.1. NC_009667.1.
YP_001371251.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6X2G8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_2710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS15422 ; ABS15422 ; Oant_2710 .
GeneIDi 5378475.
KEGGi oan:Oant_2710.
PATRICi 20470753. VBIOchAnt73124_2858.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CTDEMTI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci OANT439375:GJIT-2760-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiBETB_OCHA4
AccessioniPrimary (citable) accession number: A6X2G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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