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A6X2G7 (BETA_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:Oant_2709
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_1000046565

Regions

Nucleotide binding4 – 3330FAD By similarity

Sites

Active site4651 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6X2G7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 5A6C3FAAD0DC6C64

FASTA54960,562
        10         20         30         40         50         60 
MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS FPMNMETYDW 

        70         80         90        100        110        120 
GFSTEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAR DYDHWSESGA RGWAYADVLP 

       130        140        150        160        170        180 
YFKRMENSSG GQEGWRGTNG PLYIQRGKRD NPLFHAFVEA GHEAGFEVTE DYNGEKQEGF 

       190        200        210        220        230        240 
GPMEQTIHNG RRWSAANAYL KPALKRPNVK LVKGLARKIV LEGKRAVGVE IEAGRSFSTI 

       250        260        270        280        290        300 
RARREVIIAA SSINSPKLLM LSGIGPAAQL KEHGIEVVAD RPGVGQNLQD HLEVYIQQEC 

       310        320        330        340        350        360 
TQPITLYSKL NLFSKAKIGA EWLFFKTGDG ATNHFESAAF LRSKAGVEYP DIQYHFLPVA 

       370        380        390        400        410        420 
IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP VIKFNYMSHE DDWADFRHCV 

       430        440        450        460        470        480 
RLTREIFGQA AFNPYRGAEI QPGAHVQSDD EIDNFIKEHV ESAFHPCGTC KMGAVDDPMA 

       490        500        510        520        530        540 
VVDAECRVIG VEGLRVADSS IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSDQEPWI 


NPRWQVSDR 

« Hide

References

[1]"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000758 Genomic DNA. Translation: ABS15421.1.
RefSeqYP_001371250.1. NC_009667.1.

3D structure databases

ProteinModelPortalA6X2G7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439375.Oant_2709.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS15421; ABS15421; Oant_2709.
GeneID5379209.
KEGGoan:Oant_2709.
PATRIC20470751. VBIOchAnt73124_2857.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycOANT439375:GJIT-2759-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_OCHA4
AccessionPrimary (citable) accession number: A6X2G7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways