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A6X2G7

- BETA_OCHA4

UniProt

A6X2G7 - BETA_OCHA4

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei465 – 4651UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 3330FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciOANT439375:GJIT-2759-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:Oant_2709
    OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
    Taxonomic identifieri439375 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
    ProteomesiUP000002301: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000046565Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439375.Oant_2709.

    Structurei

    3D structure databases

    ProteinModelPortaliA6X2G7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6X2G7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS    50
    FPMNMETYDW GFSTEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAR 100
    DYDHWSESGA RGWAYADVLP YFKRMENSSG GQEGWRGTNG PLYIQRGKRD 150
    NPLFHAFVEA GHEAGFEVTE DYNGEKQEGF GPMEQTIHNG RRWSAANAYL 200
    KPALKRPNVK LVKGLARKIV LEGKRAVGVE IEAGRSFSTI RARREVIIAA 250
    SSINSPKLLM LSGIGPAAQL KEHGIEVVAD RPGVGQNLQD HLEVYIQQEC 300
    TQPITLYSKL NLFSKAKIGA EWLFFKTGDG ATNHFESAAF LRSKAGVEYP 350
    DIQYHFLPVA IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP 400
    VIKFNYMSHE DDWADFRHCV RLTREIFGQA AFNPYRGAEI QPGAHVQSDD 450
    EIDNFIKEHV ESAFHPCGTC KMGAVDDPMA VVDAECRVIG VEGLRVADSS 500
    IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSDQEPWI NPRWQVSDR 549
    Length:549
    Mass (Da):60,562
    Last modified:August 21, 2007 - v1
    Checksum:i5A6C3FAAD0DC6C64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000758 Genomic DNA. Translation: ABS15421.1.
    RefSeqiWP_012092477.1. NC_009667.1.
    YP_001371250.1. NC_009667.1.

    Genome annotation databases

    EnsemblBacteriaiABS15421; ABS15421; Oant_2709.
    GeneIDi5379209.
    KEGGioan:Oant_2709.
    PATRICi20470751. VBIOchAnt73124_2857.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000758 Genomic DNA. Translation: ABS15421.1 .
    RefSeqi WP_012092477.1. NC_009667.1.
    YP_001371250.1. NC_009667.1.

    3D structure databases

    ProteinModelPortali A6X2G7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439375.Oant_2709.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS15421 ; ABS15421 ; Oant_2709 .
    GeneIDi 5379209.
    KEGGi oan:Oant_2709.
    PATRICi 20470751. VBIOchAnt73124_2857.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci OANT439375:GJIT-2759-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
      Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
      J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

    Entry informationi

    Entry nameiBETA_OCHA4
    AccessioniPrimary (citable) accession number: A6X2G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3