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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei465Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 33FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciOANT439375:G1G9F-2877-MONOMER
UniPathwayiUPA00529; UER00385

Protein family/group databases

CAZyiAA3 Auxiliary Activities 3

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Oant_2709
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
Proteomesi
  • UP000002301 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000465651 – 549Oxygen-dependent choline dehydrogenaseAdd BLAST549

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_2709

Structurei

3D structure databases

ProteinModelPortaliA6X2G7
SMRiA6X2G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiGWDYAHC
OrthoDBiPOG091H04UT

Family and domain databases

Gene3Di3.50.50.604 hits
4.10.450.102 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6X2G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS
60 70 80 90 100
FPMNMETYDW GFSTEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAR
110 120 130 140 150
DYDHWSESGA RGWAYADVLP YFKRMENSSG GQEGWRGTNG PLYIQRGKRD
160 170 180 190 200
NPLFHAFVEA GHEAGFEVTE DYNGEKQEGF GPMEQTIHNG RRWSAANAYL
210 220 230 240 250
KPALKRPNVK LVKGLARKIV LEGKRAVGVE IEAGRSFSTI RARREVIIAA
260 270 280 290 300
SSINSPKLLM LSGIGPAAQL KEHGIEVVAD RPGVGQNLQD HLEVYIQQEC
310 320 330 340 350
TQPITLYSKL NLFSKAKIGA EWLFFKTGDG ATNHFESAAF LRSKAGVEYP
360 370 380 390 400
DIQYHFLPVA IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP
410 420 430 440 450
VIKFNYMSHE DDWADFRHCV RLTREIFGQA AFNPYRGAEI QPGAHVQSDD
460 470 480 490 500
EIDNFIKEHV ESAFHPCGTC KMGAVDDPMA VVDAECRVIG VEGLRVADSS
510 520 530 540
IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSDQEPWI NPRWQVSDR
Length:549
Mass (Da):60,562
Last modified:August 21, 2007 - v1
Checksum:i5A6C3FAAD0DC6C64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA Translation: ABS15421.1
RefSeqiWP_012092477.1, NC_009667.1

Genome annotation databases

EnsemblBacteriaiABS15421; ABS15421; Oant_2709
GeneIDi5379209
KEGGioan:Oant_2709
PATRICifig|439375.7.peg.2857

Similar proteinsi

Entry informationi

Entry nameiBETA_OCHA4
AccessioniPrimary (citable) accession number: A6X2G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome