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A6X2G7

- BETA_OCHA4

UniProt

A6X2G7 - BETA_OCHA4

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciOANT439375:GJIT-2759-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Oant_2709
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000046565Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_2709.

Structurei

3D structure databases

ProteinModelPortaliA6X2G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6X2G7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS
60 70 80 90 100
FPMNMETYDW GFSTEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAR
110 120 130 140 150
DYDHWSESGA RGWAYADVLP YFKRMENSSG GQEGWRGTNG PLYIQRGKRD
160 170 180 190 200
NPLFHAFVEA GHEAGFEVTE DYNGEKQEGF GPMEQTIHNG RRWSAANAYL
210 220 230 240 250
KPALKRPNVK LVKGLARKIV LEGKRAVGVE IEAGRSFSTI RARREVIIAA
260 270 280 290 300
SSINSPKLLM LSGIGPAAQL KEHGIEVVAD RPGVGQNLQD HLEVYIQQEC
310 320 330 340 350
TQPITLYSKL NLFSKAKIGA EWLFFKTGDG ATNHFESAAF LRSKAGVEYP
360 370 380 390 400
DIQYHFLPVA IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP
410 420 430 440 450
VIKFNYMSHE DDWADFRHCV RLTREIFGQA AFNPYRGAEI QPGAHVQSDD
460 470 480 490 500
EIDNFIKEHV ESAFHPCGTC KMGAVDDPMA VVDAECRVIG VEGLRVADSS
510 520 530 540
IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSDQEPWI NPRWQVSDR
Length:549
Mass (Da):60,562
Last modified:August 21, 2007 - v1
Checksum:i5A6C3FAAD0DC6C64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS15421.1.
RefSeqiWP_012092477.1. NC_009667.1.
YP_001371250.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS15421; ABS15421; Oant_2709.
GeneIDi5379209.
KEGGioan:Oant_2709.
PATRICi20470751. VBIOchAnt73124_2857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS15421.1 .
RefSeqi WP_012092477.1. NC_009667.1.
YP_001371250.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6X2G7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_2709.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS15421 ; ABS15421 ; Oant_2709 .
GeneIDi 5379209.
KEGGi oan:Oant_2709.
PATRICi 20470751. VBIOchAnt73124_2857.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci OANT439375:GJIT-2759-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiBETA_OCHA4
AccessioniPrimary (citable) accession number: A6X2G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3