A6X235 (PUR5_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	Oant_2576

Organism

Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]

Taxonomic identifier

439375 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum › Ochrobactrum anthropi

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741		PRO_1000046452

Sequences

	Sequence		Length	Mass (Da)
	A6X235 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 2C1FFA529F252DE6	FASTA	363	37,811
	10 20 30 40 50 60 MTMENKPADK PVGQNGLTYA QAGVDIDAGN LMVEKIKPLV RSTRRPGADG EIGGFGGLFD 70 80 90 100 110 120 LKAAGFKDPV LVAANDGVGT KLKIAIDADK HDTVGIDLVA MCVNDLVVQG AEPLFFLDYF 130 140 150 160 170 180 ATGKLSPDQG VDIVAGIAEG CRQAGSALIG GETAEMPGMY RDGDYDLAGF AVGAAERDRL 190 200 210 220 230 240 LPRGDIAEGD VILGLASSGV HSNGFSLVRR IVELSGLGWK SDAPFQPGAT LGEALLTPTR 250 260 270 280 290 300 IYVKPLLAAI RASDGIKALA HITGGGFPDN IPRVLPEGLA AEIDLESISV PAVFSWLAKT 310 320 330 340 350 360 GGVEPNEMLR TFNCGIGMIA VVKPEKVEEV VAALAAEGEK VVTLGQMVKR DKDGVVYKGT LSL

References

[1]

"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts." Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E. J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000758 Genomic DNA. Translation: ABS15289.1.
RefSeq	YP_001371118.1. NC_009667.1.
3D structure databases
ProteinModelPortal	A6X235.
SMR	A6X235. Positions 16-359.
ModBase	Search...
Protein-protein interaction databases
STRING	439375.Oant_2576.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS15289; ABS15289; Oant_2576.
GeneID	5379198.
KEGG	oan:Oant_2576.
PATRIC	20470463. VBIOchAnt73124_2714.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HOG000229090.
KO	K01933.
OMA	PRVLPKH.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	OANT439375:GJIT-2625-MONOMER.
UniPathway	UPA00074; UER00129.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_OCHA4

Accession

Primary (citable) accession number: A6X235

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program