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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOANT439375:G1G9F-2169-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Oant_2043
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
Proteomesi
  • UP000002301 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677221 – 473Glutamate--tRNA ligase 1Add BLAST473

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi439375.Oant_2043

Structurei

3D structure databases

ProteinModelPortaliA6X0K5
SMRiA6X0K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionAdd BLAST11
Motifi240 – 244"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.3501 hit
3.40.50.6201 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6X0K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPVVTRFA PSPTGYLHIG GARTALFNWL YAKHSGGKML LRIEDTDRER
60 70 80 90 100
STDAATAAIL DGLTWLGLDW DGDAISQFER APRHREVAEE LVALGKAYYC
110 120 130 140 150
YATPEELAEM REKAREEGRP PRYDGRWRDR DPSEAPAGVK PVIRIKAPQE
160 170 180 190 200
GETLVQDAVQ GDVRFPNKDL DDFIILRSDG TPTYMHAVVV DDHDMGVTHI
210 220 230 240 250
IRGDDHLTNA ARQTVIYDAM GWDVPQMSHI PLIHGADGAK LSKRHGALGV
260 270 280 290 300
DAYRAMGYLP AALRNYLVRL GWSHGDDEIM STEQMIEWFD VKDINKGAAR
310 320 330 340 350
FDFQKLEAIN GVYMRASDDK ALYDALIAVL PEIEGGKEIA DALDDKRSTQ
360 370 380 390 400
LLAAMPGLKD RAKTLVELAD SSKFIFAARP LDLDEKAASL LNDEGRAVLK
410 420 430 440 450
SVLPDLEAAG EWTVESLDGV VRTHAEKTGL KLGKIAQPLR ASLTGRATSP
460 470
GVFDVLFVLG REESLGRIRD QIG
Length:473
Mass (Da):52,210
Last modified:August 21, 2007 - v1
Checksum:iC9A27760AD05C689
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA Translation: ABS14759.1
RefSeqiWP_012091960.1, NC_009667.1

Genome annotation databases

EnsemblBacteriaiABS14759; ABS14759; Oant_2043
GeneIDi5380045
KEGGioan:Oant_2043
PATRICifig|439375.7.peg.2148

Similar proteinsi

Entry informationi

Entry nameiSYE1_OCHA4
AccessioniPrimary (citable) accession number: A6X0K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome