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A6WYD2

- MASZ_OCHA4

UniProt

A6WYD2 - MASZ_OCHA4

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Protein
Malate synthase G
Gene
glcB, Oant_1269
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei281 – 2811Acetyl-CoA By similarity
Binding sitei318 – 3181Acetyl-CoA By similarity
Active sitei345 – 3451Proton acceptor By similarity
Binding sitei345 – 3451Glyoxylate By similarity
Metal bindingi437 – 4371Magnesium By similarity
Binding sitei437 – 4371Glyoxylate By similarity
Metal bindingi465 – 4651Magnesium By similarity
Binding sitei546 – 5461Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei636 – 6361Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciOANT439375:GJIT-1286-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Oant_1269
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Malate synthase GUniRule annotation
PRO_1000056916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei622 – 6221Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi439375.Oant_1269.

Structurei

3D structure databases

ProteinModelPortaliA6WYD2.
SMRiA6WYD2. Positions 10-728.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1312Acetyl-CoA binding By similarity
Regioni462 – 4654Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

A6WYD2-1 [UniParc]FASTAAdd to Basket

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MVSQKAGNYV EIEGLRVAPE LVEFLAKEAA PGTGVEPEKF WKGFAAIIRD    50
LAPKNRALLA KRDDLQAKID AWYKQNRDKG YSQADYQQFL KNIGYLLPEG 100
GEFSVSTTNV DPEITHIAGP QLVVPVMNAR YALNAANARW GSLYDALYGT 150
DAISDADGGE KGKGYNPKRG EKVIAWAKNF LDESAPLATG NWANVAGLAV 200
KDGKLEIKLT DGSATALKDA NQFKGYNGDA AAPTNVLLAK NNMHVDIVVN 250
ADHPIGKTDP AHIADVVLES AVSTIQDCED SIAAVDAEDK VAVYRNWLGL 300
MNGKLEDTFE KNGKQMTRRL NGDRSYKAAD GSTLSLKGRS LMLVRNVGHL 350
MTNPAIIDAD GHEVPEGIMD AAFTSLIALH DIGPNGRHMN SREGSVYIVK 400
PKMHGPEEVA FANEIFTRTE EMLGMKPNTL KIGIMDEERR TTVNLKEAIR 450
AAKERVVFIN TGFLDRTGDE IHTSMEAGPM IRKGDMKQAA WIGAYEQWNV 500
DIGLECGLSG HAQIGKGMWA MPDLMAAMLE QKIAHPKAGA NTAWVPSPTA 550
ATLHATHYHQ VDVAAVQAKL KSRPRAKLDD ILSVPVATRP NWTPEDIQHE 600
IDNNAQGILG YVVRWVDQGV GCSKVPDINN VGLMEDRATL RISAQHIANW 650
LYHGVVSEAQ VMETMKRMAA VVDKQNEGDA LYRPMAADFD KSIAFQAACD 700
LVFKGREQPN GYTEPVLHRR RLELKAQG 728
Length:728
Mass (Da):79,664
Last modified:August 21, 2007 - v1
Checksum:i89C758B66592CB10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13986.1.
RefSeqiYP_001369815.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS13986; ABS13986; Oant_1269.
GeneIDi5378625.
KEGGioan:Oant_1269.
PATRICi20467633. VBIOchAnt73124_1330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13986.1 .
RefSeqi YP_001369815.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6WYD2.
SMRi A6WYD2. Positions 10-728.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_1269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS13986 ; ABS13986 ; Oant_1269 .
GeneIDi 5378625.
KEGGi oan:Oant_1269.
PATRICi 20467633. VBIOchAnt73124_1330.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci OANT439375:GJIT-1286-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiMASZ_OCHA4
AccessioniPrimary (citable) accession number: A6WYD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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