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A6WYC5 (A6WYC5_OCHA4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:Oant_1262
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP] EMBL ABS13979.1
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181

Cofactor

Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region89 – 913Substrate binding By similarity HAMAP MF_00116
Region106 – 1083Substrate binding By similarity HAMAP MF_00116

Sites

Binding site1021Substrate By similarity HAMAP MF_00116
Binding site1161Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
A6WYC5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 1BB28223B88DB278

FASTA17018,353
        10         20         30         40         50         60 
MRDETMFRKK GPLMTVASAQ APTLGIIRLE HAKGLELPAY ETTGSAGMDL RAAVAEDRQI 

        70         80         90        100        110        120 
VLLPGRRTLV PTGLIFEIPE GFEVQIRPRS GLAFKNGITC LNTPGTIDSD YRGEVKVLLI 

       130        140        150        160        170 
NLGDDDFRIE RGMRIAQAVF APVVQPKIEE RAQVTETARG AGGFGSTGTA

« Hide

References

[1]"Complete sequence of chromosome 1 of Ochrobactrum anthropi ATCC 49188."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000758 Genomic DNA. Translation: ABS13979.1.
RefSeqYP_001369808.1. NC_009667.1.

3D structure databases

ProteinModelPortalA6WYC5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6WYC5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5379101.
GenomeReviewsGene locus Oant_1262 in contig CP000758_GR.
KEGGoan:Oant_1262.
PATRIC20467619. VBIOchAnt73124_1323.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0756.
HOGENOMHBG436079.
OMALDLRACI.
ProtClustDBPRK00601.

Enzyme and pathway databases

BioCycOANT439375:OANT_1262-MONOMER.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6WYC5_OCHA4
AccessionPrimary (citable) accession number: A6WYC5
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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