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A6WXW1

- SYL_OCHA4

UniProt

A6WXW1 - SYL_OCHA4

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOANT439375:GJIT-1111-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Oant_1095
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877Leucine--tRNA ligasePRO_1000009384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_1095.

Structurei

3D structure databases

ProteinModelPortaliA6WXW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi628 – 6325"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WXW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAERYNPRV AEAHWQKVWE EDRTFETDNS DSREKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYAMG DVVARYKRAK GFNVLHPMGW DAFGMPAENA AMQNKVHPKE
110 120 130 140 150
WTYQNIATMR SQLKSMGLSL DWAREFATCD VEYYHRQQML FIDLFEKGLV
160 170 180 190 200
TRKTSKVNWD PVDNTVLANE QVVDGRGWRS GALVEQRELT QWFFKITDFS
210 220 230 240 250
EELLAGLDTL DQWPEKVRLM QRNWIGKSEG LQVRFTLDGK TAPEGFSEVE
260 270 280 290 300
VYTTRPDTLF GAAFVGISAD HPLAKKLAEN NASLTGFIEE CHQHGTSLAA
310 320 330 340 350
LETAEKKGFD TGVKVKHPFD ENWELPVYVA NFVLMEYGTG AVFGCPAHDQ
360 370 380 390 400
RDLDFANKYK LKVTPVVMPK GEDAAGFSIG ETAYTDDGVM INSRFLDGMT
410 420 430 440 450
PEAAFNEVAN RLEQTSLGNS PQASRKVQFR LRDWGISRQR YWGCPIPMIH
460 470 480 490 500
CESCGVNPVP RADLPVKLPD DVEFDRPGNP LDRHATWRHV KCPKCGADAR
510 520 530 540 550
RETDTMDTFV DSSWYYARFT APWENEPTDR KVADHWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMKVAGHVG IDEPFKGLFT QGMVVHETYK ANGQWVAPAD
610 620 630 640 650
IRIEETDGKR SAALLSTGEP VEIGSIEKMS KSKKNVVDPD DIIASYGADT
660 670 680 690 700
ARWFMLSDSP PERDVIWTEA GAEGAHRFVQ RVWRLVAEAA EHLKDVAPKT
710 720 730 740 750
GTQGEALVVS KAAHKAVKAV GDDIEKLAFN RGVARLYELV NTAAASLQQV
760 770 780 790 800
ASGNADDELK SAVRDVTEKL ILMLAPMMPH LAEQCLAVLG GKIAGRETLV
810 820 830 840 850
ARSAWPEFDP ALVVENEIVM PVQINGKKRG DLTIARDADQ ASIQQAVLEL
860 870
DFVKAALNGS SPKKVIVVPQ RIVNVVA
Length:877
Mass (Da):98,210
Last modified:August 21, 2007 - v1
Checksum:i29A56EA8E314F5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS13815.1.
RefSeqiYP_001369644.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS13815; ABS13815; Oant_1095.
GeneIDi5379321.
KEGGioan:Oant_1095.
PATRICi20467261. VBIOchAnt73124_1145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS13815.1 .
RefSeqi YP_001369644.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6WXW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_1095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS13815 ; ABS13815 ; Oant_1095 .
GeneIDi 5379321.
KEGGi oan:Oant_1095.
PATRICi 20467261. VBIOchAnt73124_1145.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci OANT439375:GJIT-1111-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiSYL_OCHA4
AccessioniPrimary (citable) accession number: A6WXW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3