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A6WXW1

- SYL_OCHA4

UniProt

A6WXW1 - SYL_OCHA4

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Protein

Leucine--tRNA ligase

Gene
leuS, Oant_1095
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOANT439375:GJIT-1111-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Oant_1095
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877Leucine--tRNA ligaseUniRule annotationPRO_1000009384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_1095.

Structurei

3D structure databases

ProteinModelPortaliA6WXW1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotationAdd
BLAST
Motifi628 – 6325"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WXW1-1 [UniParc]FASTAAdd to Basket

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MAAERYNPRV AEAHWQKVWE EDRTFETDNS DSREKYYVLE MFPYPSGRIH    50
MGHVRNYAMG DVVARYKRAK GFNVLHPMGW DAFGMPAENA AMQNKVHPKE 100
WTYQNIATMR SQLKSMGLSL DWAREFATCD VEYYHRQQML FIDLFEKGLV 150
TRKTSKVNWD PVDNTVLANE QVVDGRGWRS GALVEQRELT QWFFKITDFS 200
EELLAGLDTL DQWPEKVRLM QRNWIGKSEG LQVRFTLDGK TAPEGFSEVE 250
VYTTRPDTLF GAAFVGISAD HPLAKKLAEN NASLTGFIEE CHQHGTSLAA 300
LETAEKKGFD TGVKVKHPFD ENWELPVYVA NFVLMEYGTG AVFGCPAHDQ 350
RDLDFANKYK LKVTPVVMPK GEDAAGFSIG ETAYTDDGVM INSRFLDGMT 400
PEAAFNEVAN RLEQTSLGNS PQASRKVQFR LRDWGISRQR YWGCPIPMIH 450
CESCGVNPVP RADLPVKLPD DVEFDRPGNP LDRHATWRHV KCPKCGADAR 500
RETDTMDTFV DSSWYYARFT APWENEPTDR KVADHWLPVD QYIGGIEHAI 550
LHLLYSRFFT RAMKVAGHVG IDEPFKGLFT QGMVVHETYK ANGQWVAPAD 600
IRIEETDGKR SAALLSTGEP VEIGSIEKMS KSKKNVVDPD DIIASYGADT 650
ARWFMLSDSP PERDVIWTEA GAEGAHRFVQ RVWRLVAEAA EHLKDVAPKT 700
GTQGEALVVS KAAHKAVKAV GDDIEKLAFN RGVARLYELV NTAAASLQQV 750
ASGNADDELK SAVRDVTEKL ILMLAPMMPH LAEQCLAVLG GKIAGRETLV 800
ARSAWPEFDP ALVVENEIVM PVQINGKKRG DLTIARDADQ ASIQQAVLEL 850
DFVKAALNGS SPKKVIVVPQ RIVNVVA 877
Length:877
Mass (Da):98,210
Last modified:August 21, 2007 - v1
Checksum:i29A56EA8E314F5F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13815.1.
RefSeqiYP_001369644.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS13815; ABS13815; Oant_1095.
GeneIDi5379321.
KEGGioan:Oant_1095.
PATRICi20467261. VBIOchAnt73124_1145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13815.1 .
RefSeqi YP_001369644.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6WXW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_1095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS13815 ; ABS13815 ; Oant_1095 .
GeneIDi 5379321.
KEGGi oan:Oant_1095.
PATRICi 20467261. VBIOchAnt73124_1145.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci OANT439375:GJIT-1111-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiSYL_OCHA4
AccessioniPrimary (citable) accession number: A6WXW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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