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A6WXF0

- ODO1_OCHA4

UniProt

A6WXF0 - ODO1_OCHA4

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciOANT439375:GJIT-941-MONOMER.
RETL1328306-WGS:GSTH-3976-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:sucAUniRule annotation
Synonyms:odhAUniRule annotation
Ordered Locus Names:Oant_0933
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100110012-oxoglutarate dehydrogenase E1 componentPRO_1000065701Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi439375.Oant_0933.

Structurei

3D structure databases

ProteinModelPortaliA6WXF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A6WXF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARQEQANDV FALTSFLYGG NADYIEELYA KYEDDPNSVD PQWRDFFAKL
60 70 80 90 100
GDNADDVKKN AEGASWTRKN WPIAANGELI SALDGNWAEV EKHVTDKLKG
110 120 130 140 150
KAAKGEAKGA TGAALTSEEI TQAARDSVRA IMMIRAYRMR GHLHANLDPL
160 170 180 190 200
GLSEKPNDYN ELEPENYGFT PADYNRKIFI DNVLGLEYAT VPEMLDILKR
210 220 230 240 250
TYCGTIGVEF MHISDPAEKA WIQERIEGPD KKVAFTPEGK KAILSKLIEA
260 270 280 290 300
EGFEQFIDVK YKGTKRFGLD GGESLIPALE QIVKRGGAMG VKEIIFGMAH
310 320 330 340 350
RGRLNVLSQV MGKPHRAIFH EFKGGSYAPD DVEGSGDVKY HLGASSDREF
360 370 380 390 400
DGNKVHLSLT ANPSHLEIVN PVVMGKARAK QDLLAGRTRD DMVPLATRAK
410 420 430 440 450
VLPLLLHGDA AFAGQGVVAE CLGLSGLKGH RVAGTLHFII NNQIGFTTNP
460 470 480 490 500
AFSRSSPYPS DVAKMIEAPI FHVNGDDPEA VVFAAKVATE FRMTFHKPVV
510 520 530 540 550
IDMFCYRRFG HNEGDEPSFT QPLMYKAIRA HKTTVQLYSD KLIAEGLIKQ
560 570 580 590 600
EEIDQMKAQW RENLETEFDA GQSYKPNKAD WLDGAWAGLR TADNADEQRR
610 620 630 640 650
GKTAVPMKTL KEIGKKLVEV PKDFHVHRTI QRFLDNRAKM METGEGIDWA
660 670 680 690 700
TAESLAFGSL VAEGSPIRLS GQDVERGTFS QRHTVLYDQE TQNRYIPLNN
710 720 730 740 750
IQKGQAIYEA INSMLSEEAV LGYEYGYSLS DPRALVLWEA QFGDFANGAQ
760 770 780 790 800
VVFDQFISSG ERKWLRMSGL VCLLPHGYEG QGPEHSSARL ERWLQMCAED
810 820 830 840 850
NMQVANVTTP ANYFHILRRQ MKRDFRKPLI MMTPKSLLRH KRAVSTLNEL
860 870 880 890 900
SGESSFHRLL WDDAQYNKDE GIKLQKDAKI RRVVLCSGKV YYDLYEEREK
910 920 930 940 950
RGIDDVYLLR VEQLYPFPAK ALINELSRFR HAEMVWCQEE PKNMGAWSFI
960 970 980 990 1000
DPYLEWVLAH IDAKHQRVRY AGRPAAASPA TGLMSKHLAQ LAAFLEDALG

N
Length:1,001
Mass (Da):112,439
Last modified:August 21, 2007 - v1
Checksum:iFEFF96316C9AC4AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS13654.1.
RefSeqiYP_001369483.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS13654; ABS13654; Oant_0933.
GeneIDi5381023.
KEGGioan:Oant_0933.
PATRICi20466911. VBIOchAnt73124_0978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS13654.1 .
RefSeqi YP_001369483.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6WXF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_0933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS13654 ; ABS13654 ; Oant_0933 .
GeneIDi 5381023.
KEGGi oan:Oant_0933.
PATRICi 20466911. VBIOchAnt73124_0978.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci OANT439375:GJIT-941-MONOMER.
RETL1328306-WGS:GSTH-3976-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiODO1_OCHA4
AccessioniPrimary (citable) accession number: A6WXF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3