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A6WXF0

- ODO1_OCHA4

UniProt

A6WXF0 - ODO1_OCHA4

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
sucA, odhA, Oant_0933
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciOANT439375:GJIT-941-MONOMER.
RETL1328306-WGS:GSTH-3976-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Synonyms:odhA
Ordered Locus Names:Oant_0933
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100110012-oxoglutarate dehydrogenase E1 componentUniRule annotation
PRO_1000065701Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi439375.Oant_0933.

Structurei

3D structure databases

ProteinModelPortaliA6WXF0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A6WXF0-1 [UniParc]FASTAAdd to Basket

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MARQEQANDV FALTSFLYGG NADYIEELYA KYEDDPNSVD PQWRDFFAKL     50
GDNADDVKKN AEGASWTRKN WPIAANGELI SALDGNWAEV EKHVTDKLKG 100
KAAKGEAKGA TGAALTSEEI TQAARDSVRA IMMIRAYRMR GHLHANLDPL 150
GLSEKPNDYN ELEPENYGFT PADYNRKIFI DNVLGLEYAT VPEMLDILKR 200
TYCGTIGVEF MHISDPAEKA WIQERIEGPD KKVAFTPEGK KAILSKLIEA 250
EGFEQFIDVK YKGTKRFGLD GGESLIPALE QIVKRGGAMG VKEIIFGMAH 300
RGRLNVLSQV MGKPHRAIFH EFKGGSYAPD DVEGSGDVKY HLGASSDREF 350
DGNKVHLSLT ANPSHLEIVN PVVMGKARAK QDLLAGRTRD DMVPLATRAK 400
VLPLLLHGDA AFAGQGVVAE CLGLSGLKGH RVAGTLHFII NNQIGFTTNP 450
AFSRSSPYPS DVAKMIEAPI FHVNGDDPEA VVFAAKVATE FRMTFHKPVV 500
IDMFCYRRFG HNEGDEPSFT QPLMYKAIRA HKTTVQLYSD KLIAEGLIKQ 550
EEIDQMKAQW RENLETEFDA GQSYKPNKAD WLDGAWAGLR TADNADEQRR 600
GKTAVPMKTL KEIGKKLVEV PKDFHVHRTI QRFLDNRAKM METGEGIDWA 650
TAESLAFGSL VAEGSPIRLS GQDVERGTFS QRHTVLYDQE TQNRYIPLNN 700
IQKGQAIYEA INSMLSEEAV LGYEYGYSLS DPRALVLWEA QFGDFANGAQ 750
VVFDQFISSG ERKWLRMSGL VCLLPHGYEG QGPEHSSARL ERWLQMCAED 800
NMQVANVTTP ANYFHILRRQ MKRDFRKPLI MMTPKSLLRH KRAVSTLNEL 850
SGESSFHRLL WDDAQYNKDE GIKLQKDAKI RRVVLCSGKV YYDLYEEREK 900
RGIDDVYLLR VEQLYPFPAK ALINELSRFR HAEMVWCQEE PKNMGAWSFI 950
DPYLEWVLAH IDAKHQRVRY AGRPAAASPA TGLMSKHLAQ LAAFLEDALG 1000
N 1001
Length:1,001
Mass (Da):112,439
Last modified:August 21, 2007 - v1
Checksum:iFEFF96316C9AC4AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13654.1.
RefSeqiWP_010657592.1. NC_009667.1.
YP_001369483.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS13654; ABS13654; Oant_0933.
GeneIDi5381023.
KEGGioan:Oant_0933.
PATRICi20466911. VBIOchAnt73124_0978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13654.1 .
RefSeqi WP_010657592.1. NC_009667.1.
YP_001369483.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6WXF0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 439375.Oant_0933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS13654 ; ABS13654 ; Oant_0933 .
GeneIDi 5381023.
KEGGi oan:Oant_0933.
PATRICi 20466911. VBIOchAnt73124_0978.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci OANT439375:GJIT-941-MONOMER.
RETL1328306-WGS:GSTH-3976-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiODO1_OCHA4
AccessioniPrimary (citable) accession number: A6WXF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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