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A6WXF0

- ODO1_OCHA4

UniProt

A6WXF0 - ODO1_OCHA4

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciOANT439375:GJIT-941-MONOMER.
    RETL1328306-WGS:GSTH-3976-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:sucAUniRule annotation
    Synonyms:odhAUniRule annotation
    Ordered Locus Names:Oant_0933
    OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
    Taxonomic identifieri439375 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
    ProteomesiUP000002301: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 100110012-oxoglutarate dehydrogenase E1 componentPRO_1000065701Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi439375.Oant_0933.

    Structurei

    3D structure databases

    ProteinModelPortaliA6WXF0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259586.
    KOiK00164.
    OMAiGHQNANL.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6WXF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARQEQANDV FALTSFLYGG NADYIEELYA KYEDDPNSVD PQWRDFFAKL     50
    GDNADDVKKN AEGASWTRKN WPIAANGELI SALDGNWAEV EKHVTDKLKG 100
    KAAKGEAKGA TGAALTSEEI TQAARDSVRA IMMIRAYRMR GHLHANLDPL 150
    GLSEKPNDYN ELEPENYGFT PADYNRKIFI DNVLGLEYAT VPEMLDILKR 200
    TYCGTIGVEF MHISDPAEKA WIQERIEGPD KKVAFTPEGK KAILSKLIEA 250
    EGFEQFIDVK YKGTKRFGLD GGESLIPALE QIVKRGGAMG VKEIIFGMAH 300
    RGRLNVLSQV MGKPHRAIFH EFKGGSYAPD DVEGSGDVKY HLGASSDREF 350
    DGNKVHLSLT ANPSHLEIVN PVVMGKARAK QDLLAGRTRD DMVPLATRAK 400
    VLPLLLHGDA AFAGQGVVAE CLGLSGLKGH RVAGTLHFII NNQIGFTTNP 450
    AFSRSSPYPS DVAKMIEAPI FHVNGDDPEA VVFAAKVATE FRMTFHKPVV 500
    IDMFCYRRFG HNEGDEPSFT QPLMYKAIRA HKTTVQLYSD KLIAEGLIKQ 550
    EEIDQMKAQW RENLETEFDA GQSYKPNKAD WLDGAWAGLR TADNADEQRR 600
    GKTAVPMKTL KEIGKKLVEV PKDFHVHRTI QRFLDNRAKM METGEGIDWA 650
    TAESLAFGSL VAEGSPIRLS GQDVERGTFS QRHTVLYDQE TQNRYIPLNN 700
    IQKGQAIYEA INSMLSEEAV LGYEYGYSLS DPRALVLWEA QFGDFANGAQ 750
    VVFDQFISSG ERKWLRMSGL VCLLPHGYEG QGPEHSSARL ERWLQMCAED 800
    NMQVANVTTP ANYFHILRRQ MKRDFRKPLI MMTPKSLLRH KRAVSTLNEL 850
    SGESSFHRLL WDDAQYNKDE GIKLQKDAKI RRVVLCSGKV YYDLYEEREK 900
    RGIDDVYLLR VEQLYPFPAK ALINELSRFR HAEMVWCQEE PKNMGAWSFI 950
    DPYLEWVLAH IDAKHQRVRY AGRPAAASPA TGLMSKHLAQ LAAFLEDALG 1000
    N 1001
    Length:1,001
    Mass (Da):112,439
    Last modified:August 21, 2007 - v1
    Checksum:iFEFF96316C9AC4AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000758 Genomic DNA. Translation: ABS13654.1.
    RefSeqiWP_010657592.1. NC_009667.1.
    YP_001369483.1. NC_009667.1.

    Genome annotation databases

    EnsemblBacteriaiABS13654; ABS13654; Oant_0933.
    GeneIDi5381023.
    KEGGioan:Oant_0933.
    PATRICi20466911. VBIOchAnt73124_0978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000758 Genomic DNA. Translation: ABS13654.1 .
    RefSeqi WP_010657592.1. NC_009667.1.
    YP_001369483.1. NC_009667.1.

    3D structure databases

    ProteinModelPortali A6WXF0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439375.Oant_0933.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS13654 ; ABS13654 ; Oant_0933 .
    GeneIDi 5381023.
    KEGGi oan:Oant_0933.
    PATRICi 20466911. VBIOchAnt73124_0978.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259586.
    KOi K00164.
    OMAi GHQNANL.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci OANT439375:GJIT-941-MONOMER.
    RETL1328306-WGS:GSTH-3976-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
      Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
      J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

    Entry informationi

    Entry nameiODO1_OCHA4
    AccessioniPrimary (citable) accession number: A6WXF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3