Reviewed, UniProtKB/Swiss-Prot A6WXF0 (ODO1_OCHA4)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase E1 component
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase

Gene names

Name:	sucA
Synonyms:	odhA
Ordered Locus Names:	Oant_0933

Organism

Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]

Taxonomic identifier

439375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Protein attributes

Sequence length	1001 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP MF_01169
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamin pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1001	1001	2-oxoglutarate dehydrogenase E1 component HAMAP MF_01169		PRO_1000065701

Sequences

	Sequence		Length	Mass (Da)
	A6WXF0-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: FEFF96316C9AC4AB	FASTA	1,001	112,439
	10 20 30 40 50 60 MARQEQANDV FALTSFLYGG NADYIEELYA KYEDDPNSVD PQWRDFFAKL GDNADDVKKN 70 80 90 100 110 120 AEGASWTRKN WPIAANGELI SALDGNWAEV EKHVTDKLKG KAAKGEAKGA TGAALTSEEI 130 140 150 160 170 180 TQAARDSVRA IMMIRAYRMR GHLHANLDPL GLSEKPNDYN ELEPENYGFT PADYNRKIFI 190 200 210 220 230 240 DNVLGLEYAT VPEMLDILKR TYCGTIGVEF MHISDPAEKA WIQERIEGPD KKVAFTPEGK 250 260 270 280 290 300 KAILSKLIEA EGFEQFIDVK YKGTKRFGLD GGESLIPALE QIVKRGGAMG VKEIIFGMAH 310 320 330 340 350 360 RGRLNVLSQV MGKPHRAIFH EFKGGSYAPD DVEGSGDVKY HLGASSDREF DGNKVHLSLT 370 380 390 400 410 420 ANPSHLEIVN PVVMGKARAK QDLLAGRTRD DMVPLATRAK VLPLLLHGDA AFAGQGVVAE 430 440 450 460 470 480 CLGLSGLKGH RVAGTLHFII NNQIGFTTNP AFSRSSPYPS DVAKMIEAPI FHVNGDDPEA 490 500 510 520 530 540 VVFAAKVATE FRMTFHKPVV IDMFCYRRFG HNEGDEPSFT QPLMYKAIRA HKTTVQLYSD 550 560 570 580 590 600 KLIAEGLIKQ EEIDQMKAQW RENLETEFDA GQSYKPNKAD WLDGAWAGLR TADNADEQRR 610 620 630 640 650 660 GKTAVPMKTL KEIGKKLVEV PKDFHVHRTI QRFLDNRAKM METGEGIDWA TAESLAFGSL 670 680 690 700 710 720 VAEGSPIRLS GQDVERGTFS QRHTVLYDQE TQNRYIPLNN IQKGQAIYEA INSMLSEEAV 730 740 750 760 770 780 LGYEYGYSLS DPRALVLWEA QFGDFANGAQ VVFDQFISSG ERKWLRMSGL VCLLPHGYEG 790 800 810 820 830 840 QGPEHSSARL ERWLQMCAED NMQVANVTTP ANYFHILRRQ MKRDFRKPLI MMTPKSLLRH 850 860 870 880 890 900 KRAVSTLNEL SGESSFHRLL WDDAQYNKDE GIKLQKDAKI RRVVLCSGKV YYDLYEEREK 910 920 930 940 950 960 RGIDDVYLLR VEQLYPFPAK ALINELSRFR HAEMVWCQEE PKNMGAWSFI DPYLEWVLAH 970 980 990 1000 IDAKHQRVRY AGRPAAASPA TGLMSKHLAQ LAAFLEDALG N

References

[1]

"Complete sequence of chromosome 1 of Ochrobactrum anthropi ATCC 49188." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000758 Genomic DNA. Translation: ABS13654.1.
RefSeq	YP_001369483.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5381023.
GenomeReviews	Gene locus Oant_0933 in contig CP000758_GR.
KEGG	oan:Oant_0933.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A6WXF0. EGDEPAF.
Family and domain databases
HAMAP	MF_01169. [Tree]
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase_central-reg. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_OCHA4

Accession

Primary (citable) accession number: A6WXF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)