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A6WXF0 (ODO1_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Synonyms:odhA
Ordered Locus Names:Oant_0933
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum

Protein attributes

Sequence length1001 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 100110012-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_1000065701

Sequences

Sequence LengthMass (Da)Tools
A6WXF0 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: FEFF96316C9AC4AB

FASTA1,001112,439
        10         20         30         40         50         60 
MARQEQANDV FALTSFLYGG NADYIEELYA KYEDDPNSVD PQWRDFFAKL GDNADDVKKN 

        70         80         90        100        110        120 
AEGASWTRKN WPIAANGELI SALDGNWAEV EKHVTDKLKG KAAKGEAKGA TGAALTSEEI 

       130        140        150        160        170        180 
TQAARDSVRA IMMIRAYRMR GHLHANLDPL GLSEKPNDYN ELEPENYGFT PADYNRKIFI 

       190        200        210        220        230        240 
DNVLGLEYAT VPEMLDILKR TYCGTIGVEF MHISDPAEKA WIQERIEGPD KKVAFTPEGK 

       250        260        270        280        290        300 
KAILSKLIEA EGFEQFIDVK YKGTKRFGLD GGESLIPALE QIVKRGGAMG VKEIIFGMAH 

       310        320        330        340        350        360 
RGRLNVLSQV MGKPHRAIFH EFKGGSYAPD DVEGSGDVKY HLGASSDREF DGNKVHLSLT 

       370        380        390        400        410        420 
ANPSHLEIVN PVVMGKARAK QDLLAGRTRD DMVPLATRAK VLPLLLHGDA AFAGQGVVAE 

       430        440        450        460        470        480 
CLGLSGLKGH RVAGTLHFII NNQIGFTTNP AFSRSSPYPS DVAKMIEAPI FHVNGDDPEA 

       490        500        510        520        530        540 
VVFAAKVATE FRMTFHKPVV IDMFCYRRFG HNEGDEPSFT QPLMYKAIRA HKTTVQLYSD 

       550        560        570        580        590        600 
KLIAEGLIKQ EEIDQMKAQW RENLETEFDA GQSYKPNKAD WLDGAWAGLR TADNADEQRR 

       610        620        630        640        650        660 
GKTAVPMKTL KEIGKKLVEV PKDFHVHRTI QRFLDNRAKM METGEGIDWA TAESLAFGSL 

       670        680        690        700        710        720 
VAEGSPIRLS GQDVERGTFS QRHTVLYDQE TQNRYIPLNN IQKGQAIYEA INSMLSEEAV 

       730        740        750        760        770        780 
LGYEYGYSLS DPRALVLWEA QFGDFANGAQ VVFDQFISSG ERKWLRMSGL VCLLPHGYEG 

       790        800        810        820        830        840 
QGPEHSSARL ERWLQMCAED NMQVANVTTP ANYFHILRRQ MKRDFRKPLI MMTPKSLLRH 

       850        860        870        880        890        900 
KRAVSTLNEL SGESSFHRLL WDDAQYNKDE GIKLQKDAKI RRVVLCSGKV YYDLYEEREK 

       910        920        930        940        950        960 
RGIDDVYLLR VEQLYPFPAK ALINELSRFR HAEMVWCQEE PKNMGAWSFI DPYLEWVLAH 

       970        980        990       1000 
IDAKHQRVRY AGRPAAASPA TGLMSKHLAQ LAAFLEDALG N 

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References

[1]"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000758 Genomic DNA. Translation: ABS13654.1.
RefSeqYP_001369483.1. NC_009667.1.

3D structure databases

ProteinModelPortalA6WXF0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439375.Oant_0933.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS13654; ABS13654; Oant_0933.
GeneID5381023.
KEGGoan:Oant_0933.
PATRIC20466911. VBIOchAnt73124_0978.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259586.
KOK00164.
OMAGHQNANL.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycOANT439375:GJIT-941-MONOMER.
RETL1328306-WGS:GSTH-3976-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_OCHA4
AccessionPrimary (citable) accession number: A6WXF0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families