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A6WXC7 (AROB_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Oant_0910
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3783783-dehydroquinate synthase HAMAP MF_00110
PRO_1000094557

Sequences

Sequence LengthMass (Da)Tools
A6WXC7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: C45D8655FD5B1820

FASTA37840,257
        10         20         30         40         50         60 
MNAPSIAQDV TTVPVSLGNR SYDILIGKGL VDRAGEELAK RLKGVRVAVV TDENVAKAHL 

        70         80         90        100        110        120 
ERLTASFAKA GVDVTPVIVA PGEKSKSFGT LETVTNAVLA ARLERGDAVV AFGGGVVGDL 

       130        140        150        160        170        180 
SGFVAGIVRR GMNFVQMPTS LLSQVDSSVG GKTGVNTAHG KNLVGVFYQP QLVLADTEVL 

       190        200        210        220        230        240 
DTLSPREFRA GYAEVAKYGL IDRPDFFEWL EQNWQEVFSG GAARTQAIAE SCRCKAAVVA 

       250        260        270        280        290        300 
RDERETGDRA LLNLGHTFGH ALETATGYDS TRLVHGEGVA IGMALAHRFS VKMNLCGIED 

       310        320        330        340        350        360 
AERVEAHLKA VGLPYRLSDV PGGLPPAEKL MDYIAQDKKV ARGALTFILT RGIGQSFIAK 

       370 
DVPPAAVLGF LKERLETK

« Hide

References

[1]"Complete sequence of chromosome 1 of Ochrobactrum anthropi ATCC 49188."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000758 Genomic DNA. Translation: ABS13631.1.
RefSeqYP_001369460.1. NC_009667.1.

3D structure databases

ProteinModelPortalA6WXC7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6WXC7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5378474.
GenomeReviewsGene locus Oant_0910 in contig CP000758_GR.
KEGGoan:Oant_0910.
PATRIC20466859. VBIOchAnt73124_0952.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycOANT439375:OANT_0910-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_OCHA4
AccessionPrimary (citable) accession number: A6WXC7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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