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A6WWI2

- MTB1_OCHA4

UniProt

A6WWI2 - MTB1_OCHA4

Protein

Modification methylase BabI

Gene

ccrM

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciOANT439375:GJIT-611-MONOMER.
    RETL1328306-WGS:GSTH-1016-MONOMER.

    Protein family/group databases

    REBASEi15992. M.OanORF605P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase BabI (EC:2.1.1.72)
    Short name:
    M.BabI
    Alternative name(s):
    Adenine-specific methyltransferase BabI
    DNA methyltransferase CcrM
    M.CcrMI ortholog
    Gene namesi
    Name:ccrM
    Ordered Locus Names:Oant_0605
    OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
    Taxonomic identifieri439375 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
    ProteomesiUP000002301: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Modification methylase BabIPRO_0000363194Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439375.Oant_0605.

    Structurei

    3D structure databases

    ProteinModelPortaliA6WWI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0863.
    HOGENOMiHOG000125329.
    KOiK13581.
    OMAiFWHFEDG.
    OrthoDBiEOG6FV84T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6WWI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLVRLAHEL PIEAPRTAWL DSIIKGDCVA ALERLPDHSV DVIFADPPYN    50
    LQLGGDLHRP DQSMVSAVDD HWDQFESFQA YDAFTRAWLM ACRRVLKPNG 100
    TIWVIGSYHN IFRVGSQLQD LGFWLLNDVI WRKTNPMPNF RGRRFQNAHE 150
    TLIWASRDQK GKGYTFNYEA MKAANDDVQM RSDWLFPICT GSERLKDENG 200
    DKVHPTQKPE ALLARIMMAS SKPGDVILDP FFGSGTTGAV AKRLGRHFVG 250
    IEREQSYIDA ATARIDAVEP LGKAELTVMT GKRAEPRVAF TSVLEAGLLR 300
    PGTVLCDERR RFAAIVRADG TLAANGEAGS IHRIGAKVQG FDACNGWTFW 350
    HYEENGALKP IDALRKVIRD QMAVAGA 377
    Length:377
    Mass (Da):42,079
    Last modified:August 21, 2007 - v1
    Checksum:i0D0B34E4710E708B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000758 Genomic DNA. Translation: ABS13336.1.
    RefSeqiYP_001369165.1. NC_009667.1.

    Genome annotation databases

    EnsemblBacteriaiABS13336; ABS13336; Oant_0605.
    GeneIDi5379433.
    KEGGioan:Oant_0605.
    PATRICi20466241. VBIOchAnt73124_0645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000758 Genomic DNA. Translation: ABS13336.1 .
    RefSeqi YP_001369165.1. NC_009667.1.

    3D structure databases

    ProteinModelPortali A6WWI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439375.Oant_0605.

    Protein family/group databases

    REBASEi 15992. M.OanORF605P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS13336 ; ABS13336 ; Oant_0605 .
    GeneIDi 5379433.
    KEGGi oan:Oant_0605.
    PATRICi 20466241. VBIOchAnt73124_0645.

    Phylogenomic databases

    eggNOGi COG0863.
    HOGENOMi HOG000125329.
    KOi K13581.
    OMAi FWHFEDG.
    OrthoDBi EOG6FV84T.

    Enzyme and pathway databases

    BioCyci OANT439375:GJIT-611-MONOMER.
    RETL1328306-WGS:GSTH-1016-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
      Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
      J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

    Entry informationi

    Entry nameiMTB1_OCHA4
    AccessioniPrimary (citable) accession number: A6WWI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3