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A6WWI2 (MTB1_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase BabI

Short name=M.BabI
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase BabI
DNA methyltransferase CcrM
M.CcrMI ortholog
Gene names
Name:ccrM
Ordered Locus Names:Oant_0605
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Modification methylase BabI
PRO_0000363194

Sequences

Sequence LengthMass (Da)Tools
A6WWI2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 0D0B34E4710E708B

FASTA37742,079
        10         20         30         40         50         60 
MSLVRLAHEL PIEAPRTAWL DSIIKGDCVA ALERLPDHSV DVIFADPPYN LQLGGDLHRP 

        70         80         90        100        110        120 
DQSMVSAVDD HWDQFESFQA YDAFTRAWLM ACRRVLKPNG TIWVIGSYHN IFRVGSQLQD 

       130        140        150        160        170        180 
LGFWLLNDVI WRKTNPMPNF RGRRFQNAHE TLIWASRDQK GKGYTFNYEA MKAANDDVQM 

       190        200        210        220        230        240 
RSDWLFPICT GSERLKDENG DKVHPTQKPE ALLARIMMAS SKPGDVILDP FFGSGTTGAV 

       250        260        270        280        290        300 
AKRLGRHFVG IEREQSYIDA ATARIDAVEP LGKAELTVMT GKRAEPRVAF TSVLEAGLLR 

       310        320        330        340        350        360 
PGTVLCDERR RFAAIVRADG TLAANGEAGS IHRIGAKVQG FDACNGWTFW HYEENGALKP 

       370 
IDALRKVIRD QMAVAGA 

« Hide

References

[1]"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000758 Genomic DNA. Translation: ABS13336.1.
RefSeqYP_001369165.1. NC_009667.1.

3D structure databases

ProteinModelPortalA6WWI2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439375.Oant_0605.

Protein family/group databases

REBASE15992. M.OanORF605P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS13336; ABS13336; Oant_0605.
GeneID5379433.
KEGGoan:Oant_0605.
PATRIC20466241. VBIOchAnt73124_0645.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0863.
HOGENOMHOG000125329.
KOK13581.
OMAFWHFEDG.
OrthoDBEOG6FV84T.
ProtClustDBCLSK2518600.

Enzyme and pathway databases

BioCycOANT439375:GJIT-611-MONOMER.

Family and domain databases

InterProIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
[Graphical view]
PfamPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSPR00508. S21N4MTFRASE.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTB1_OCHA4
AccessionPrimary (citable) accession number: A6WWI2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families