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A6WWI2

- MTB1_OCHA4

UniProt

A6WWI2 - MTB1_OCHA4

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Protein
Modification methylase BabI
Gene
ccrM, Oant_0605
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciOANT439375:GJIT-611-MONOMER.
RETL1328306-WGS:GSTH-1016-MONOMER.

Protein family/group databases

REBASEi15992. M.OanORF605P.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase BabI (EC:2.1.1.72)
Short name:
M.BabI
Alternative name(s):
Adenine-specific methyltransferase BabI
DNA methyltransferase CcrM
M.CcrMI ortholog
Gene namesi
Name:ccrM
Ordered Locus Names:Oant_0605
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Modification methylase BabI
PRO_0000363194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_0605.

Structurei

3D structure databases

ProteinModelPortaliA6WWI2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0863.
HOGENOMiHOG000125329.
KOiK13581.
OMAiFWHFEDG.
OrthoDBiEOG6FV84T.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WWI2-1 [UniParc]FASTAAdd to Basket

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MSLVRLAHEL PIEAPRTAWL DSIIKGDCVA ALERLPDHSV DVIFADPPYN    50
LQLGGDLHRP DQSMVSAVDD HWDQFESFQA YDAFTRAWLM ACRRVLKPNG 100
TIWVIGSYHN IFRVGSQLQD LGFWLLNDVI WRKTNPMPNF RGRRFQNAHE 150
TLIWASRDQK GKGYTFNYEA MKAANDDVQM RSDWLFPICT GSERLKDENG 200
DKVHPTQKPE ALLARIMMAS SKPGDVILDP FFGSGTTGAV AKRLGRHFVG 250
IEREQSYIDA ATARIDAVEP LGKAELTVMT GKRAEPRVAF TSVLEAGLLR 300
PGTVLCDERR RFAAIVRADG TLAANGEAGS IHRIGAKVQG FDACNGWTFW 350
HYEENGALKP IDALRKVIRD QMAVAGA 377
Length:377
Mass (Da):42,079
Last modified:August 21, 2007 - v1
Checksum:i0D0B34E4710E708B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13336.1.
RefSeqiYP_001369165.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS13336; ABS13336; Oant_0605.
GeneIDi5379433.
KEGGioan:Oant_0605.
PATRICi20466241. VBIOchAnt73124_0645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS13336.1 .
RefSeqi YP_001369165.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6WWI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_0605.

Protein family/group databases

REBASEi 15992. M.OanORF605P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS13336 ; ABS13336 ; Oant_0605 .
GeneIDi 5379433.
KEGGi oan:Oant_0605.
PATRICi 20466241. VBIOchAnt73124_0645.

Phylogenomic databases

eggNOGi COG0863.
HOGENOMi HOG000125329.
KOi K13581.
OMAi FWHFEDG.
OrthoDBi EOG6FV84T.

Enzyme and pathway databases

BioCyci OANT439375:GJIT-611-MONOMER.
RETL1328306-WGS:GSTH-1016-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01555. N6_N4_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00508. S21N4MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiMTB1_OCHA4
AccessioniPrimary (citable) accession number: A6WWI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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