A6WWG7 (KHSE_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Oant_0590

Organism

Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]

Taxonomic identifier

439375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Ochrobactrum

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_1000022587

Sequences

	Sequence		Length	Mass (Da)
	A6WWG7 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: E3D9B659A2482F63	FASTA	326	36,526
	10 20 30 40 50 60 MAVYTDINEI ELGAFLQQYD IGTLTSYKGI AEGVENSNYL LHTTSGSFIL TLYEKRTNRE 70 80 90 100 110 120 DLPFFLGLMQ HLASRGLECP QPVVRRDGTT IGELAGRPAA IVTFLEGMWM RRPTVEHCEA 130 140 150 160 170 180 VGEGLAHMHL AGADFSLRRR NGLTLADWRP LWNLSRGRAD TVEPGLVREA EADLAFLEKN 190 200 210 220 230 240 WPADLPQGVI HADLFPDNVF FLGDRLSGFI DFYFACTDTL AYDVAVCLNA WCFEKDFSYN 250 260 270 280 290 300 RTKGAALLRG YTSVRPLSAA EADALPVLAR GAAIRFMLTR LYDWLNVPEG SFVVKKDPME 310 320 YVRKIRFHRQ IETAAEYGLE QQGAAA

References

[1]

"Complete sequence of chromosome 1 of Ochrobactrum anthropi ATCC 49188." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000758 Genomic DNA. Translation: ABS13321.1.
RefSeq	YP_001369150.1. NC_009667.1.
3D structure databases
ProteinModelPortal	A6WWG7.
SMR	A6WWG7. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	A6WWG7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5378839.
GenomeReviews	Gene locus Oant_0590 in contig CP000758_GR.
KEGG	oan:Oant_0590.
PATRIC	20466211. VBIOchAnt73124_0630.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	OANT439375:OANT_0590-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_OCHA4

Accession

Primary (citable) accession number: A6WWG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program