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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donorUniRule annotation
Active sitei384 – 3841UniRule annotation
Active sitei513 – 5131UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciOANT439375:GJIT-375-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Oant_0369
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301 Componenti: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomerasePRO_1000013993Add
BLAST

Proteomic databases

PRIDEiA6WVU6.

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_0369.

Structurei

3D structure databases

ProteinModelPortaliA6WVU6.
SMRiA6WVU6. Positions 13-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WVU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDATKLEA TVAKLKKHWA DSAPHDMRAA FKSDPGRFER YSLSLDDLLF
60 70 80 90 100
DWSKCRVNDE TIGLLKELAI AADVEGRRAA MFAGEHINNT EDRAVLHVAL
110 120 130 140 150
RDTSSKEVLV DGHNVLPDVK EVLDRMAAFA DGIRSGAIKG ATGKKITDIV
160 170 180 190 200
NIGIGGSDLG PVMATLALSP YHDGPRAHFV SNIDGAHIAD TLGILDPATT
210 220 230 240 250
LVIIASKTFT TIETMTNAQT ARKWVADALG EAAVGAHFAA VSTALDRVAA
260 270 280 290 300
FGIAEDRVFG FWDWVGGRYS VWSAIGLPVM IAIGPEDFRK FLAGAHSMDV
310 320 330 340 350
HFRDAPLEKN LAVWLGLIGY WHRAICGYGS RAIIPYDQRL ARLPAYLQQL
360 370 380 390 400
DMESNGKSVT VDGKPVSGPT GPVVWGEPGT NGQHAFFQLL HQGTDTIPLE
410 420 430 440 450
FIVAAKGHEK HLDHQHEMLL ANCLAQSEAL MKGRTLDEAR AQLKAKNLPE
460 470 480 490 500
SEVERIAPHR VFSGNRPSLT LVHDKLDPFA LGRLVALYEH RVFVEAQIFG
510 520 530 540
INAFDQWGVE LGKELATELL PVVSGEESSD GRDASTQGLV AHLHARRKA
Length:549
Mass (Da):59,734
Last modified:August 21, 2007 - v1
Checksum:iAAE345733D237F17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS13100.1.
RefSeqiYP_001368929.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS13100; ABS13100; Oant_0369.
KEGGioan:Oant_0369.
PATRICi20465735. VBIOchAnt73124_0392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA. Translation: ABS13100.1.
RefSeqiYP_001368929.1. NC_009667.1.

3D structure databases

ProteinModelPortaliA6WVU6.
SMRiA6WVU6. Positions 13-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi439375.Oant_0369.

Proteomic databases

PRIDEiA6WVU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS13100; ABS13100; Oant_0369.
KEGGioan:Oant_0369.
PATRICi20465735. VBIOchAnt73124_0392.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciOANT439375:GJIT-375-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiG6PI_OCHA4
AccessioniPrimary (citable) accession number: A6WVU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: April 1, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.