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A6WV52 (PNCB_OCHA4) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:Oant_0125
OrganismOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168) [Complete proteome] [HAMAP]
Taxonomic identifier439375 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000025003

Sequences

Sequence LengthMass (Da)Tools
A6WV52 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 53753B7439871B21

FASTA43449,921
        10         20         30         40         50         60 
MAKTDIARRV YNHAWKLDPI VRSLLDTDFY KLLMLQMIWG LYPKVDATFS LINRTTSVRL 

        70         80         90        100        110        120 
ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNSFYGRKQI FQPEFLNWLH DFQLPEYDLR 

       130        140        150        160        170        180 
RKDGQYELHF HGPWSHTTMW EIPALAIINE LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV 

       190        200        210        220        230        240 
ERLRQLPGLK ISDFGTRRRH SFLWQRWCVE ALKEGIGDAF TGTSNVLLAM DTDLEALGTN 

       250        260        270        280        290        300 
AHELPMVLAA LAKNDEELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 

       310        320        330        340        350        360 
WTGFRPDSAP PIEGGERIIE WWKSRGKDPR EKLLIFSDAL DVDTIEETYR HFEGRVRMSF 

       370        380        390        400        410        420 
GWGTNLTNDF AGCAPKEIEG LNAISLVCKV TDANGHPAVK LSDNPQKATG DPKEVARYLK 

       430 
FFGNEERVEQ LVRV 

« Hide

References

[1]"Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000758 Genomic DNA. Translation: ABS12856.1.
RefSeqYP_001368685.1. NC_009667.1.

3D structure databases

ProteinModelPortalA6WV52.
SMRA6WV52. Positions 1-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439375.Oant_0125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS12856; ABS12856; Oant_0125.
GeneID5378787.
KEGGoan:Oant_0125.
PATRIC20465209. VBIOchAnt73124_0133.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284929.
KOK00763.
OMAKLTMQCA.
OrthoDBEOG6X10XB.
ProtClustDBPRK05321.

Enzyme and pathway databases

BioCycOANT439375:GJIT-127-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_OCHA4
AccessionPrimary (citable) accession number: A6WV52
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways