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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Oant_0125
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
Proteomesi
  • UP000002301 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000250031 – 434Nicotinate phosphoribosyltransferaseAdd BLAST434

Proteomic databases

PRIDEiA6WV52

Interactioni

Protein-protein interaction databases

STRINGi439375.Oant_0125

Structurei

3D structure databases

ProteinModelPortaliA6WV52
SMRiA6WV52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284929
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

A6WV52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTDIARRV YNHAWKLDPI VRSLLDTDFY KLLMLQMIWG LYPKVDATFS
60 70 80 90 100
LINRTTSVRL ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNSFYGRKQI
110 120 130 140 150
FQPEFLNWLH DFQLPEYDLR RKDGQYELHF HGPWSHTTMW EIPALAIINE
160 170 180 190 200
LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV ERLRQLPGLK ISDFGTRRRH
210 220 230 240 250
SFLWQRWCVE ALKEGIGDAF TGTSNVLLAM DTDLEALGTN AHELPMVLAA
260 270 280 290 300
LAKNDEELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD
310 320 330 340 350
WTGFRPDSAP PIEGGERIIE WWKSRGKDPR EKLLIFSDAL DVDTIEETYR
360 370 380 390 400
HFEGRVRMSF GWGTNLTNDF AGCAPKEIEG LNAISLVCKV TDANGHPAVK
410 420 430
LSDNPQKATG DPKEVARYLK FFGNEERVEQ LVRV
Length:434
Mass (Da):49,921
Last modified:August 21, 2007 - v1
Checksum:i53753B7439871B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000758 Genomic DNA Translation: ABS12856.1
RefSeqiWP_010657961.1, NC_009667.1

Genome annotation databases

EnsemblBacteriaiABS12856; ABS12856; Oant_0125
GeneIDi5378787
KEGGioan:Oant_0125

Similar proteinsi

Entry informationi

Entry nameiPNCB_OCHA4
AccessioniPrimary (citable) accession number: A6WV52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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