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A6WV13

- ASSY_OCHA4

UniProt

A6WV13 - ASSY_OCHA4

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Protein
Argininosuccinate synthase
Gene
argG, Oant_0086
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei96 – 961Citrulline By similarity
Binding sitei121 – 1211ATP; via amide nitrogen By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei131 – 1311Citrulline By similarity
Binding sitei182 – 1821Citrulline By similarity
Binding sitei191 – 1911Citrulline By similarity
Binding sitei267 – 2671Citrulline By similarity
Binding sitei279 – 2791Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOANT439375:GJIT-88-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Oant_0086
OrganismiOchrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
Taxonomic identifieri439375 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeOchrobactrum
ProteomesiUP000002301: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Argininosuccinate synthaseUniRule annotation
PRO_0000321313Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi439375.Oant_0086.

Structurei

3D structure databases

ProteinModelPortaliA6WV13.
SMRiA6WV13. Positions 9-405.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WV13-1 [UniParc]FASTAAdd to Basket

« Hide

MSKWKDVKKV VLAYSGGLDT SIILKWLQTE LGAEVVTFTA DLGQGEELEP    50
ARKKAEMLGI KEIFIEDVRE EFVRDFVFPM FRANAVYEGV YLLGTSIARP 100
LISKHLIEIA RKTGADAIAH GATGKGNDQV RFELSAYALN PDIKIIAPWR 150
DWSFKSRTHL LEFAEQHQIP VAKDKKGEAP FSVDANLLHS SSEGKVLEDP 200
AVEAPEYVHM RTISPETAPD KATIIKIGFE KGDAVSINGE RLSPATLLAK 250
LNDYGRDNGI GRLDLVENRF VGMKSRGVYE TPGGTILLAA HRAIESITLD 300
RGAAHLKDEL MPRYAELIYY GFWFSPEREM LQAAIDHSQR HVEGEVTLKL 350
YKGNVMVIGR ESDKSLYSDK LVTFEDDQGA YDQKDAAGFI KLNALRLRTL 400
AARDRK 406
Length:406
Mass (Da):45,323
Last modified:February 26, 2008 - v2
Checksum:i05E2A94D51504FF7
GO

Sequence cautioni

The sequence ABS12817.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS12817.1. Different initiation.
RefSeqiYP_001368646.1. NC_009667.1.

Genome annotation databases

EnsemblBacteriaiABS12817; ABS12817; Oant_0086.
GeneIDi5380027.
KEGGioan:Oant_0086.
PATRICi20465119. VBIOchAnt73124_0088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000758 Genomic DNA. Translation: ABS12817.1 . Different initiation.
RefSeqi YP_001368646.1. NC_009667.1.

3D structure databases

ProteinModelPortali A6WV13.
SMRi A6WV13. Positions 9-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439375.Oant_0086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS12817 ; ABS12817 ; Oant_0086 .
GeneIDi 5380027.
KEGGi oan:Oant_0086.
PATRICi 20465119. VBIOchAnt73124_0088.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci OANT439375:GJIT-88-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic pathogen and symbiont of several eukaryotic hosts."
    Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M., Ugalde R.A., Garcia E., Tolmasky M.E.
    J. Bacteriol. 193:4274-4275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49188 / DSM 6882 / NCTC 12168.

Entry informationi

Entry nameiASSY_OCHA4
AccessioniPrimary (citable) accession number: A6WV13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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