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A6WSY9

- FTHS_SHEB8

UniProt

A6WSY9 - FTHS_SHEB8

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Shew185_3804
Organism
Shewanella baltica (strain OS185)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL402882:GJ99-3928-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Shew185_3804
OrganismiShewanella baltica (strain OS185)
Taxonomic identifieri402882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000006387: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000068794Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402882.Shew185_3804.

Structurei

3D structure databases

ProteinModelPortaliA6WSY9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiKWNISYT.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WSY9-1 [UniParc]FASTAAdd to Basket

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MLTDMNISSR ASLKNITELG ADLGLLPEEM MLFGHTKAKV ELSVLQRLAG    50
QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP 100
VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH 150
EARLGKKEFE AQSGQAFLAI DPNEIRWHRV VDHNDRCLRQ IHVGLGDNNG 200
PEYESSFDIT AASELMAILA LSHDLADMRA RIGRLVLALN TQGQVITADD 250
LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI 300
ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN 350
SGLATEVDSN VSNIHVPNIN ATNINAPDQA RLEAGFANLN WHINNVARYG 400
IPVVVAINRF ATDSDAELQW LMEAVNASAA FGCEISDAFS QGEAGAIALA 450
QTVVRAAETE SQFKLLYPDE VSLEAKLSTL AEVGYGAAGV SLSIEAKQQA 500
QQLTALGYGH LPLCMAKTPL SISHDPSLKG VPKDFVVPVR ELVLHAGAGF 550
ITALVGNVMT MPGLGLKPGY LKIDIDAKGE IVGLG 585
Length:585
Mass (Da):61,477
Last modified:August 21, 2007 - v1
Checksum:i63780632AA87C3E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000753 Genomic DNA. Translation: ABS09928.1.
RefSeqiYP_001367991.1. NC_009665.1.

Genome annotation databases

EnsemblBacteriaiABS09928; ABS09928; Shew185_3804.
GeneIDi5370913.
KEGGisbm:Shew185_3804.
PATRICi23464683. VBISheBal127872_4084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000753 Genomic DNA. Translation: ABS09928.1 .
RefSeqi YP_001367991.1. NC_009665.1.

3D structure databases

ProteinModelPortali A6WSY9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 402882.Shew185_3804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS09928 ; ABS09928 ; Shew185_3804 .
GeneIDi 5370913.
KEGGi sbm:Shew185_3804.
PATRICi 23464683. VBISheBal127872_4084.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi KWNISYT.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SBAL402882:GJ99-3928-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS185.

Entry informationi

Entry nameiFTHS_SHEB8
AccessioniPrimary (citable) accession number: A6WSY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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