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A6WSL1

- GCSP_SHEB8

UniProt

A6WSL1 - GCSP_SHEB8

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella baltica (strain OS185)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSBAL402882:GJ99-3795-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Shew185_3675
    OrganismiShewanella baltica (strain OS185)
    Taxonomic identifieri402882 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000006387: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000045608Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi402882.Shew185_3675.

    Structurei

    3D structure databases

    ProteinModelPortaliA6WSL1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6WSL1-1 [UniParc]FASTAAdd to Basket

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    MTKQTLTQLE QHDLFLRRHI GPDSNQQQAM LNFVGAESLE DLTAQIVPES    50
    IRLSQDLSIG DSCGEAEGIA YIRGLADQNQ VFKSYIGMGY YGTQVPNVIL 100
    RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
    EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
    VGPANEAVNY ELFGALFQYT NRFGQITDFT ELFATLRAKN VIVTVAADIM 250
    SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 300
    IIGVSKDARG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
    FHGPDGLKTI ASRINRFADI LAAGLQAKGV SLVNSTWFDT ISIKGLDVAA 400
    VNARALAAEM NLRFDADGTV GVSLDETTLR TDIEALFDVI LGADHGLDVA 450
    ALDAQIVSQG SQSIPAALVR QDAILSHPTF NRYQSETEMM RYIKRLESKD 500
    LALNYSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFSPL DQAKGYTQLI 550
    EELSTWLVNI TGYDAVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL 600
    IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKTKA AEVAGNLSCI 650
    MITYPSTHGV YEESIREICD IVHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
    DVSHLNLHKT FAIPHGGGGP GMGPIGVKSH LAPFVAGHVV VKPGRESDHN 750
    GAVSAAPYGS AGILPISWMY IKLLGSQGLK KSTQTALLNA NYVMKKLSEH 800
    YPVLFRGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF 850
    PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVESGE WPVDNNPLHN 900
    APHTMADIMD PEFDTRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN 950
    LFCACVPLSD YE 962
    Length:962
    Mass (Da):104,769
    Last modified:August 21, 2007 - v1
    Checksum:i6B4D954BD83FAE02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000753 Genomic DNA. Translation: ABS09800.1.
    RefSeqiWP_012090199.1. NC_009665.1.
    YP_001367863.1. NC_009665.1.

    Genome annotation databases

    EnsemblBacteriaiABS09800; ABS09800; Shew185_3675.
    GeneIDi5372024.
    KEGGisbm:Shew185_3675.
    PATRICi23464411. VBISheBal127872_3952.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000753 Genomic DNA. Translation: ABS09800.1 .
    RefSeqi WP_012090199.1. NC_009665.1.
    YP_001367863.1. NC_009665.1.

    3D structure databases

    ProteinModelPortali A6WSL1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402882.Shew185_3675.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS09800 ; ABS09800 ; Shew185_3675 .
    GeneIDi 5372024.
    KEGGi sbm:Shew185_3675.
    PATRICi 23464411. VBISheBal127872_3952.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SBAL402882:GJ99-3795-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS185.

    Entry informationi

    Entry nameiGCSP_SHEB8
    AccessioniPrimary (citable) accession number: A6WSL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3