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A6WSL1

- GCSP_SHEB8

UniProt

A6WSL1 - GCSP_SHEB8

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Shew185_3675
Organism
Shewanella baltica (strain OS185)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSBAL402882:GJ99-3795-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Shew185_3675
OrganismiShewanella baltica (strain OS185)
Taxonomic identifieri402882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000006387: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi402882.Shew185_3675.

Structurei

3D structure databases

ProteinModelPortaliA6WSL1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A6WSL1-1 [UniParc]FASTAAdd to Basket

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MTKQTLTQLE QHDLFLRRHI GPDSNQQQAM LNFVGAESLE DLTAQIVPES    50
IRLSQDLSIG DSCGEAEGIA YIRGLADQNQ VFKSYIGMGY YGTQVPNVIL 100
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
VGPANEAVNY ELFGALFQYT NRFGQITDFT ELFATLRAKN VIVTVAADIM 250
SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 300
IIGVSKDARG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
FHGPDGLKTI ASRINRFADI LAAGLQAKGV SLVNSTWFDT ISIKGLDVAA 400
VNARALAAEM NLRFDADGTV GVSLDETTLR TDIEALFDVI LGADHGLDVA 450
ALDAQIVSQG SQSIPAALVR QDAILSHPTF NRYQSETEMM RYIKRLESKD 500
LALNYSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFSPL DQAKGYTQLI 550
EELSTWLVNI TGYDAVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL 600
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKTKA AEVAGNLSCI 650
MITYPSTHGV YEESIREICD IVHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKSH LAPFVAGHVV VKPGRESDHN 750
GAVSAAPYGS AGILPISWMY IKLLGSQGLK KSTQTALLNA NYVMKKLSEH 800
YPVLFRGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF 850
PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVESGE WPVDNNPLHN 900
APHTMADIMD PEFDTRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN 950
LFCACVPLSD YE 962
Length:962
Mass (Da):104,769
Last modified:August 21, 2007 - v1
Checksum:i6B4D954BD83FAE02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000753 Genomic DNA. Translation: ABS09800.1.
RefSeqiWP_012090199.1. NC_009665.1.
YP_001367863.1. NC_009665.1.

Genome annotation databases

EnsemblBacteriaiABS09800; ABS09800; Shew185_3675.
GeneIDi5372024.
KEGGisbm:Shew185_3675.
PATRICi23464411. VBISheBal127872_3952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000753 Genomic DNA. Translation: ABS09800.1 .
RefSeqi WP_012090199.1. NC_009665.1.
YP_001367863.1. NC_009665.1.

3D structure databases

ProteinModelPortali A6WSL1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402882.Shew185_3675.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS09800 ; ABS09800 ; Shew185_3675 .
GeneIDi 5372024.
KEGGi sbm:Shew185_3675.
PATRICi 23464411. VBISheBal127872_3952.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SBAL402882:GJ99-3795-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS185.

Entry informationi

Entry nameiGCSP_SHEB8
AccessioniPrimary (citable) accession number: A6WSL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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