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A6WSH6 (A6WSH6_SHEB8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:Shew185_3640
OrganismShewanella baltica (strain OS185) [Complete proteome] [HAMAP] EMBL ABS09765.1
Taxonomic identifier402882 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length756 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6421Zinc By similarity HAMAP MF_00172
Metal binding6441Zinc By similarity HAMAP MF_00172
Metal binding7271Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
A6WSH6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: C096A198B74A8AC9

FASTA75684,423
        10         20         30         40         50         60 
MQLNSLGFPR IGRRRELKFA LEKYWRGEIT QAELREVASE LRRTHWQWQT AAGIEQVPVG 

        70         80         90        100        110        120 
DFAFYDQVLT LSATLNAIPD RHRGEGAIDL DTLFRVARGR APTGQDAPAS EMTKYFNTNY 

       130        140        150        160        170        180 
HYLVPELTQN QEFSIAYEQF FDEVSEAQAL GYKAKPVLLG PVSYLYLAKT VGQEFDKLSL 

       190        200        210        220        230        240 
LPNLLTAYAD ILARFAAQGV EWVQLDEPVL ALELDLHWQA AMTKTYQALS TANVKVLLAS 

       250        260        270        280        290        300 
YYGGIAHHQA LVSALPVAGL HLDLVTAPEQ LAVFANALGQ DQMLSAGVVN GRNVWAAEID 

       310        320        330        340        350        360 
LIAERIGAVA RDLGDRLWIG TSCSLLHSPV DLDVEVKLLP VLRKQLAFAK QKLLELSKVR 

       370        380        390        400        410        420 
QLLLAPSSDE AQKISAFCIA RRQAKAQAAD KQVVDRVAAL TAADYERAND FSVRQSVQQQ 

       430        440        450        460        470        480 
KYHLPLLPTT TIGSFPQTPA IRGLRSRWRK GELNDAQYNE QLQQVTRDTI ERQLKLGIDV 

       490        500        510        520        530        540 
LVHGEAERND MVEYFGEQLA GVGFSKNGWV QSYGSRCVKP PLIYGDVSRP KDMTVEWAEF 

       550        560        570        580        590        600 
AQSLTDKPVK GMLTGPVTIL HWSFAREDIS RDAIATQLAL AIRDEVVDLQ NAGIGIIQID 

       610        620        630        640        650        660 
EPAFREGLPL KQSEWQAYLD WAVNAFKLSA AGVTDETQIH THMCYSEFND TIGAIAAMDA 

       670        680        690        700        710        720 
DVITIETSRS RMELLNAFED FEYPNEIGPG VYDIHSPNTP SVEAMVHLIE KAAQKVPVRQ 

       730        740        750 
LWVNPDCGLK TRTWDEVEPA LKNMVDATRE LRRRLG

« Hide

References

[1]"Complete sequence of chromosome of Shewanella baltica OS185."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Brettar I., Rodrigues J., Konstantinidis K., Tiedje J., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS185.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000753 Genomic DNA. Translation: ABS09765.1.
RefSeqYP_001367828.1. NC_009665.1.

3D structure databases

ProteinModelPortalA6WSH6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6WSH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5373111.
GenomeReviewsGene locus Shew185_3640 in contig CP000753_GR.
KEGGsbm:Shew185_3640.
PATRIC23464341. VBISheBal127872_3917.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHBG287495.
OMANIWANDF.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycSBAL402882:SHEW185_3640-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6WSH6_SHEB8
AccessionPrimary (citable) accession number: A6WSH6
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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