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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Shewanella baltica (strain OS185)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi20Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi23Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi100Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei225S-adenosyl-L-methionineUniRule annotation1
Binding sitei254S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei275S-adenosyl-L-methionineUniRule annotation1
Binding sitei322S-adenosyl-L-methionineUniRule annotation1
Active sitei349NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:Shew185_3496
OrganismiShewanella baltica (strain OS185)
Taxonomic identifieri402882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000630061 – 39023S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST390

Proteomic databases

PRIDEiA6WS34

Structurei

3D structure databases

ProteinModelPortaliA6WS34
SMRiA6WS34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218547
KOiK03212
OMAiSCQWLEK

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR001566 23S_rRNA_MeTrfase_RlmD
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
TIGR00479 rumA, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6WS34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAIVNAVK QCGYFNQGQC LSCRHIQQPL AQQVAVKTQT LQQLLAPFIP
60 70 80 90 100
ANSAELFLPP ITGDDSGFRN KAKMVVLGAA HEPVLGIVSP SGEAVDLCDC
110 120 130 140 150
LLYPGDMQAL LHRLTRFVQQ AGLPPYRVDK AKGELKFILL TRSQVRGEYL
160 170 180 190 200
LRFVLRSHNG IERIERELPA LLAEYPQIKV VSVNIQPIHM AILEGDEEIF
210 220 230 240 250
LTENTRLEER FNHVPLFIRP KSFFQTNPQV AAQLYQTARD WVAEFSPRSL
260 270 280 290 300
WDLFCGVGGF GLHCASNDIT LTGIEIEAEA IACAQMSAQM MGLENVQFMA
310 320 330 340 350
LDSTDFAKGK SAADKPDLII VNPPRRGIGE ALCQSLSEFA PKAILYSSCN
360 370 380 390
PKTLAKDLEH IQGYHLTKVQ LFDLFPHTDH FEVLAMLVKD
Length:390
Mass (Da):43,316
Last modified:August 21, 2007 - v1
Checksum:iD1D0D87F7C46D5A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000753 Genomic DNA Translation: ABS09623.1

Genome annotation databases

EnsemblBacteriaiABS09623; ABS09623; Shew185_3496
KEGGisbm:Shew185_3496

Similar proteinsi

Entry informationi

Entry nameiRLMC_SHEB8
AccessioniPrimary (citable) accession number: A6WS34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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