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A6WNN5

- SERC_SHEB8

UniProt

A6WNN5 - SERC_SHEB8

Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Shewanella baltica (strain OS185)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotation

    Catalytic activityi

    O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation
    4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421L-glutamateUniRule annotation
    Binding sitei102 – 1021Pyridoxal phosphateUniRule annotation
    Binding sitei156 – 1561Pyridoxal phosphateUniRule annotation
    Binding sitei175 – 1751Pyridoxal phosphateUniRule annotation
    Binding sitei198 – 1981Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-serine biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Pyridoxine biosynthesis, Serine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSBAL402882:GJ99-2349-MONOMER.
    UniPathwayiUPA00135; UER00197.
    UPA00244; UER00311.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
    Alternative name(s):
    Phosphohydroxythreonine aminotransferaseUniRule annotation
    Short name:
    PSATUniRule annotation
    Gene namesi
    Name:serCUniRule annotation
    Ordered Locus Names:Shew185_2286
    OrganismiShewanella baltica (strain OS185)
    Taxonomic identifieri402882 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000006387: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Phosphoserine aminotransferasePRO_1000203564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei199 – 1991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi402882.Shew185_2286.

    Structurei

    3D structure databases

    ProteinModelPortaliA6WNN5.
    SMRiA6WNN5. Positions 3-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 772Pyridoxal phosphate bindingUniRule annotation
    Regioni240 – 2412Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1932.
    HOGENOMiHOG000088965.
    KOiK00831.
    OMAiFAAIPMN.
    OrthoDBiEOG60CWP3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00160. SerC_aminotrans_5.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR003248. Pser_aminoTfrase_subgr.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000525. SerC. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01364. serC_1. 1 hit.
    PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6WNN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAIYNFCAG PAMLPAAVMK KAQQELLDWN GQGVSVMEIS HRSKEFIALT    50
    QQAESDLREL MQIPTNYHVL FMHGGGRGQF SAVVNNFLGN HGRALYLVSG 100
    QWSSAALAEA QKLVGEAQID SLNIVEKHNG LNAVVLPDLH KIDADYRYVH 150
    YCPNETVDGI EIFDELDSPW PIVADLSSTI MSREIDVSRY GLIYAGAQKN 200
    IGPSGLSIVI VRDDMLKLPS LPQSSIMDYR LAVEHDSMFN TPPTFAWYLA 250
    AEVFAWLKST GGISSIAKIN QQKAQMLYQC IDGNAFYRNG VVAANRSQMN 300
    VTFQLVNEAL DGEFLKQAQI AGLVALKGHR IVGGMRASLY NAMPLDGIVA 350
    LVKFMNEFAA KHS 363
    Length:363
    Mass (Da):39,932
    Last modified:August 21, 2007 - v1
    Checksum:i11AE5917C9F11260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000753 Genomic DNA. Translation: ABS08424.1.
    RefSeqiYP_001366487.1. NC_009665.1.

    Genome annotation databases

    EnsemblBacteriaiABS08424; ABS08424; Shew185_2286.
    GeneIDi5372307.
    KEGGisbm:Shew185_2286.
    PATRICi23461383. VBISheBal127872_2495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000753 Genomic DNA. Translation: ABS08424.1 .
    RefSeqi YP_001366487.1. NC_009665.1.

    3D structure databases

    ProteinModelPortali A6WNN5.
    SMRi A6WNN5. Positions 3-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402882.Shew185_2286.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS08424 ; ABS08424 ; Shew185_2286 .
    GeneIDi 5372307.
    KEGGi sbm:Shew185_2286.
    PATRICi 23461383. VBISheBal127872_2495.

    Phylogenomic databases

    eggNOGi COG1932.
    HOGENOMi HOG000088965.
    KOi K00831.
    OMAi FAAIPMN.
    OrthoDBi EOG60CWP3.

    Enzyme and pathway databases

    UniPathwayi UPA00135 ; UER00197 .
    UPA00244 ; UER00311 .
    BioCyci SBAL402882:GJ99-2349-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00160. SerC_aminotrans_5.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR003248. Pser_aminoTfrase_subgr.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000525. SerC. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01364. serC_1. 1 hit.
    PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS185.

    Entry informationi

    Entry nameiSERC_SHEB8
    AccessioniPrimary (citable) accession number: A6WNN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3