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A6WL02

- NADK_SHEB8

UniProt

A6WL02 - NADK_SHEB8

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Protein

NAD kinase

Gene

nadK

Organism
Shewanella baltica (strain OS185)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Binding sitei174 – 1741NADUniRule annotation
Binding sitei191 – 1911NADUniRule annotation
Binding sitei193 – 1931NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902NADUniRule annotation
Nucleotide bindingi163 – 1642NADUniRule annotation
Nucleotide bindingi204 – 2096NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL402882:GJ99-1377-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Shew185_1341
OrganismiShewanella baltica (strain OS185)
Taxonomic identifieri402882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000006387: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309NAD kinasePRO_1000079510Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402882.Shew185_1341.

Structurei

3D structure databases

ProteinModelPortaliA6WL02.
SMRiA6WL02. Positions 21-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiGAEFCLN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A6WL02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGINFDVSRP KARSSINMIT KFHTIGLIGK PHHQGTNQTL KRLHHWLTMQ
60 70 80 90 100
GFEVLVEERV AAELGPNIEA VDLLEIGARC DLAIVVGGDG NMLGAARVLA
110 120 130 140 150
RFDLGVIGVN RGNLGFLTDL PPDAFEEALA KVLDGEFDTE HRFLLEAEVY
160 170 180 190 200
RHGMLKASNT AVNEAVLHPG KIAHMIEFEV YIDDQFMYSQ RADGMIVSTP
210 220 230 240 250
TGSTAYALSA GGAILTPNLQ ALILVPMFPH TLSCRPIVVD ACSTIKMVVS
260 270 280 290 300
PDNGENLEVS CDGHVHLAVL PGDEIIVRRS SERLRLIHPK GHNYFHVLRT

KLGWGSKLF
Length:309
Mass (Da):33,871
Last modified:August 21, 2007 - v1
Checksum:iEC9445D16CFEBC91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000753 Genomic DNA. Translation: ABS07491.1.
RefSeqiYP_001365554.1. NC_009665.1.

Genome annotation databases

EnsemblBacteriaiABS07491; ABS07491; Shew185_1341.
GeneIDi5369773.
KEGGisbm:Shew185_1341.
PATRICi23459351. VBISheBal127872_1506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000753 Genomic DNA. Translation: ABS07491.1 .
RefSeqi YP_001365554.1. NC_009665.1.

3D structure databases

ProteinModelPortali A6WL02.
SMRi A6WL02. Positions 21-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402882.Shew185_1341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS07491 ; ABS07491 ; Shew185_1341 .
GeneIDi 5369773.
KEGGi sbm:Shew185_1341.
PATRICi 23459351. VBISheBal127872_1506.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi GAEFCLN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SBAL402882:GJ99-1377-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS185.

Entry informationi

Entry nameiNADK_SHEB8
AccessioniPrimary (citable) accession number: A6WL02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3