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Protein

Probable DNA ligase

Gene

lig

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei212ATPUniRule annotation1
Active sitei214N6-AMP-lysine intermediateUniRule annotation1
Binding sitei219ATPUniRule annotation1
Binding sitei234ATPUniRule annotation1
Binding sitei263ATPUniRule annotation1
Binding sitei296ATPUniRule annotation1
Binding sitei368ATPUniRule annotation1
Binding sitei374ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Krad_4316
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaKineosporialesKineosporiaceaeKineococcus
Proteomesi
  • UP000001116 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652201 – 503Probable DNA ligaseAdd BLAST503

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_4316.

Structurei

3D structure databases

ProteinModelPortaliA6WG40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT. Bacteria.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiDVETLDC.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WG40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLADVVATS TAVAATRSRT AKVAAIAGLL RGLDPADAEL TAVVAAYLGG
60 70 80 90 100
SLRQRRTGLG GRSLSGLPAP AGEASLEVAE VDRRFEEVAA LSGPGSAGRR
110 120 130 140 150
AAAVADLFAR ATGEEQRWLR GVVAGELRQG ALDALVQDAA AAVAGVPGPD
160 170 180 190 200
VRRAAMLAGS TVQAVVAALR GGAAELAGFG LHVGRPLLPM LAASTTSVAE
210 220 230 240 250
AVAGFAGPVA VDTKLDGIRI QVHRGPEGVR IATRTLEDIT ARLPEVVEVV
260 270 280 290 300
RELPARAFVL DGEALVLDGS GRPKAFQDTA SRTAQASGDA VVPYFFDVLH
310 320 330 340 350
LDGADLLDVA LRERLAALDG FVPPRWRTPR LVTADPAAAA EFAAQALAGG
360 370 380 390 400
HEGVVVKDLD SPYAAGRRGG AWVKVKPVHT LDLVVLAVER GSGRRAGWLS
410 420 430 440 450
NVHLGARDPA TGGFVMLGKT FKGMTDETLA WQTARFRELQ TGEDGYVVTV
460 470 480 490 500
RPEQVVEVAF DGLQRSTRYP GGVALRFARV VRYREDKTAA EADTLETVLA

LAR
Length:503
Mass (Da):52,420
Last modified:August 21, 2007 - v1
Checksum:iE70DBA8C7C4CE942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS05779.1.
RefSeqiWP_012085921.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS05779; ABS05779; Krad_4316.
KEGGikra:Krad_4316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS05779.1.
RefSeqiWP_012085921.1. NC_009664.2.

3D structure databases

ProteinModelPortaliA6WG40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266940.Krad_4316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS05779; ABS05779; Krad_4316.
KEGGikra:Krad_4316.

Phylogenomic databases

eggNOGiENOG4107RYT. Bacteria.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiDVETLDC.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNLI_KINRD
AccessioniPrimary (citable) accession number: A6WG40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: August 21, 2007
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.