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A6WG40

- DNLI_KINRD

UniProt

A6WG40 - DNLI_KINRD

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Protein

Probable DNA ligase

Gene

lig

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121ATPUniRule annotation
Active sitei214 – 2141N6-AMP-lysine intermediateUniRule annotation
Binding sitei219 – 2191ATPUniRule annotation
Binding sitei234 – 2341ATPUniRule annotation
Binding sitei263 – 2631ATPUniRule annotation
Binding sitei296 – 2961ATPUniRule annotation
Binding sitei368 – 3681ATPUniRule annotation
Binding sitei374 – 3741ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKRAD266940:GI4N-2454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Krad_4316
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus
ProteomesiUP000001116: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Probable DNA ligasePRO_0000365220Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_4316.

Structurei

3D structure databases

ProteinModelPortaliA6WG40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiVPIVIPY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WG40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLADVVATS TAVAATRSRT AKVAAIAGLL RGLDPADAEL TAVVAAYLGG
60 70 80 90 100
SLRQRRTGLG GRSLSGLPAP AGEASLEVAE VDRRFEEVAA LSGPGSAGRR
110 120 130 140 150
AAAVADLFAR ATGEEQRWLR GVVAGELRQG ALDALVQDAA AAVAGVPGPD
160 170 180 190 200
VRRAAMLAGS TVQAVVAALR GGAAELAGFG LHVGRPLLPM LAASTTSVAE
210 220 230 240 250
AVAGFAGPVA VDTKLDGIRI QVHRGPEGVR IATRTLEDIT ARLPEVVEVV
260 270 280 290 300
RELPARAFVL DGEALVLDGS GRPKAFQDTA SRTAQASGDA VVPYFFDVLH
310 320 330 340 350
LDGADLLDVA LRERLAALDG FVPPRWRTPR LVTADPAAAA EFAAQALAGG
360 370 380 390 400
HEGVVVKDLD SPYAAGRRGG AWVKVKPVHT LDLVVLAVER GSGRRAGWLS
410 420 430 440 450
NVHLGARDPA TGGFVMLGKT FKGMTDETLA WQTARFRELQ TGEDGYVVTV
460 470 480 490 500
RPEQVVEVAF DGLQRSTRYP GGVALRFARV VRYREDKTAA EADTLETVLA

LAR
Length:503
Mass (Da):52,420
Last modified:August 21, 2007 - v1
Checksum:iE70DBA8C7C4CE942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS05779.1.
RefSeqiWP_012085921.1. NC_009664.2.
YP_001364043.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS05779; ABS05779; Krad_4316.
GeneIDi5336581.
KEGGikra:Krad_4316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS05779.1 .
RefSeqi WP_012085921.1. NC_009664.2.
YP_001364043.1. NC_009664.2.

3D structure databases

ProteinModelPortali A6WG40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266940.Krad_4316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS05779 ; ABS05779 ; Krad_4316 .
GeneIDi 5336581.
KEGGi kra:Krad_4316.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi VPIVIPY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci KRAD266940:GI4N-2454-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Entry informationi

Entry nameiDNLI_KINRD
AccessioniPrimary (citable) accession number: A6WG40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3