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A6WG40

- DNLI_KINRD

UniProt

A6WG40 - DNLI_KINRD

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Protein
Probable DNA ligase
Gene
lig, Krad_4316
Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121ATP By similarity
Active sitei214 – 2141N6-AMP-lysine intermediate By similarity
Binding sitei219 – 2191ATP By similarity
Binding sitei234 – 2341ATP By similarity
Binding sitei263 – 2631ATP By similarity
Binding sitei296 – 2961ATP By similarity
Binding sitei368 – 3681ATP By similarity
Binding sitei374 – 3741ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKRAD266940:GI4N-2454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:Krad_4316
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus
ProteomesiUP000001116: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Probable DNA ligaseUniRule annotation
PRO_0000365220Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_4316.

Structurei

3D structure databases

ProteinModelPortaliA6WG40.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiVPIVIPY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WG40-1 [UniParc]FASTAAdd to Basket

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MLLADVVATS TAVAATRSRT AKVAAIAGLL RGLDPADAEL TAVVAAYLGG    50
SLRQRRTGLG GRSLSGLPAP AGEASLEVAE VDRRFEEVAA LSGPGSAGRR 100
AAAVADLFAR ATGEEQRWLR GVVAGELRQG ALDALVQDAA AAVAGVPGPD 150
VRRAAMLAGS TVQAVVAALR GGAAELAGFG LHVGRPLLPM LAASTTSVAE 200
AVAGFAGPVA VDTKLDGIRI QVHRGPEGVR IATRTLEDIT ARLPEVVEVV 250
RELPARAFVL DGEALVLDGS GRPKAFQDTA SRTAQASGDA VVPYFFDVLH 300
LDGADLLDVA LRERLAALDG FVPPRWRTPR LVTADPAAAA EFAAQALAGG 350
HEGVVVKDLD SPYAAGRRGG AWVKVKPVHT LDLVVLAVER GSGRRAGWLS 400
NVHLGARDPA TGGFVMLGKT FKGMTDETLA WQTARFRELQ TGEDGYVVTV 450
RPEQVVEVAF DGLQRSTRYP GGVALRFARV VRYREDKTAA EADTLETVLA 500
LAR 503
Length:503
Mass (Da):52,420
Last modified:August 21, 2007 - v1
Checksum:iE70DBA8C7C4CE942
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS05779.1.
RefSeqiWP_012085921.1. NC_009664.2.
YP_001364043.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS05779; ABS05779; Krad_4316.
GeneIDi5336581.
KEGGikra:Krad_4316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS05779.1 .
RefSeqi WP_012085921.1. NC_009664.2.
YP_001364043.1. NC_009664.2.

3D structure databases

ProteinModelPortali A6WG40.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266940.Krad_4316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS05779 ; ABS05779 ; Krad_4316 .
GeneIDi 5336581.
KEGGi kra:Krad_4316.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi VPIVIPY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci KRAD266940:GI4N-2454-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Entry informationi

Entry nameiDNLI_KINRD
AccessioniPrimary (citable) accession number: A6WG40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi