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A6WG40 (DNLI_KINRD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA ligase
EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Krad_4316
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP]
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Probable DNA ligase HAMAP MF_00407
PRO_0000365220

Sites

Active site2141N6-AMP-lysine intermediate By similarity
Binding site2121ATP By similarity
Binding site2191ATP By similarity
Binding site2341ATP By similarity
Binding site2631ATP By similarity
Binding site2961ATP By similarity
Binding site3681ATP By similarity
Binding site3741ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6WG40 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: E70DBA8C7C4CE942

FASTA50352,420
        10         20         30         40         50         60 
MLLADVVATS TAVAATRSRT AKVAAIAGLL RGLDPADAEL TAVVAAYLGG SLRQRRTGLG 

        70         80         90        100        110        120 
GRSLSGLPAP AGEASLEVAE VDRRFEEVAA LSGPGSAGRR AAAVADLFAR ATGEEQRWLR 

       130        140        150        160        170        180 
GVVAGELRQG ALDALVQDAA AAVAGVPGPD VRRAAMLAGS TVQAVVAALR GGAAELAGFG 

       190        200        210        220        230        240 
LHVGRPLLPM LAASTTSVAE AVAGFAGPVA VDTKLDGIRI QVHRGPEGVR IATRTLEDIT 

       250        260        270        280        290        300 
ARLPEVVEVV RELPARAFVL DGEALVLDGS GRPKAFQDTA SRTAQASGDA VVPYFFDVLH 

       310        320        330        340        350        360 
LDGADLLDVA LRERLAALDG FVPPRWRTPR LVTADPAAAA EFAAQALAGG HEGVVVKDLD 

       370        380        390        400        410        420 
SPYAAGRRGG AWVKVKPVHT LDLVVLAVER GSGRRAGWLS NVHLGARDPA TGGFVMLGKT 

       430        440        450        460        470        480 
FKGMTDETLA WQTARFRELQ TGEDGYVVTV RPEQVVEVAF DGLQRSTRYP GGVALRFARV 

       490        500 
VRYREDKTAA EADTLETVLA LAR

« Hide

References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS05779.1.
RefSeqYP_001364043.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6WG40.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6WG40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5336581.
GenomeReviewsGene locus Krad_4316 in contig CP000750_GR.
KEGGkra:Krad_4316.
NMPDRfig|266940.1.peg.3644.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHBG570821.
OMADETLAWQ.
ProtClustDBPRK03180.

Enzyme and pathway databases

BioCycKRAD266940:KRAD_4316-MONOMER.

Family and domain databases

HAMAPMF_00407. DNA_ligase.
[Tree]
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
[Graphical view]
Gene3DG3DSA:1.10.3260.10. DNA_ligase_ATP-dep_N. 1 hit.
G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK01971.
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. False negative.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_KINRD
AccessionPrimary (citable) accession number: A6WG40
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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