A6WFC5 (IOLG_KINRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Krad_4051

Organism

Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP]

Taxonomic identifier

266940 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.
Sequence caution	The sequence ABS05514.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352570

Sequences

	Sequence		Length	Mass (Da)
	A6WFC5 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 2628A4CBDD705353	FASTA	329	34,862
	10 20 30 40 50 60 MRVAVLGVGM MGQDHARRLA TLTKGAQLVA VSDVDAARTD AVAAELGVRA VHDPAAAIAD 70 80 90 100 110 120 PEVDAVVIAT PGFTHEGLVL EAIAAGKPTL CEKPLTTSPE TARAVVEAER ALGRPLVQVG 130 140 150 160 170 180 FMRRFDAEYE QLRALVASRE LGRPLFLHCV HRNATTPPNF NSEMLILDSV VHEVDIARFL 190 200 210 220 230 240 LGEEITAITV LTPGRTAHAP EGLQDPQFVL METASGTLVD VEIFVNTTFG YEVRTELVAE 250 260 270 280 290 300 RGSAMTGLGV GLVQHSAAGW GGRIAADFKQ RFGAAYDTEF QRWVDAVRSG AGVDGPGVWD 310 320 GYAAAAVCAA GVQSLRTGRR VEVDLGARS

References

[1]

"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000750 Genomic DNA. Translation: ABS05514.1. Different initiation.
RefSeq	YP_001363778.1. NC_009664.2.
3D structure databases
ProteinModelPortal	A6WFC5.
ModBase	Search...
Protein-protein interaction databases
STRING	A6WFC5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5336871.
GenomeReviews	Gene locus Krad_4051 in contig CP000750_GR.
KEGG	kra:Krad_4051.
NMPDR	fig|266940.1.peg.3669.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
Enzyme and pathway databases
BioCyc	KRAD266940:KRAD_4051-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_KINRD

Accession

Primary (citable) accession number: A6WFC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program