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A6WF62

- A6WF62_KINRD

UniProt

A6WF62 - A6WF62_KINRD

Protein

Isocitrate dehydrogenase [NADP]

Gene

Krad_3988

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771Substrate
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091Substrate
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Binding sitei259 – 2591NADPUniRule annotation
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
    Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi309 – 3146NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciKRAD266940:GI4N-2786-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Krad_3988Imported
    OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)Imported
    Taxonomic identifieri266940 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus
    ProteomesiUP000001116: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi266940.Krad_3988.

    Structurei

    3D structure databases

    ProteinModelPortaliA6WF62.
    SMRiA6WF62. Positions 3-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6WF62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVQGPV VELDGDEMTR IIWQFIKDRL VHPYLDVDLE YYDLGVEHRD    50
    ATDDQVTIDA AHAIQRAGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR 100
    NILGGVIFRE PIIISNIPRL VPGWTKPIIV GRHAYGDQYR ATDFKFPSAG 150
    TLTVTFTPED GSEPIEHEVF QAPGAGVSLS MYNLDASIVD FARSSLNYGL 200
    ARNYPVYLST KNTILKAYDG RFKDIFEEVF ENEFKDRFAE AGITYEHRLI 250
    DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLSTPDGS 300
    VVEAEAAHGT VTRHYRQHQQ GKPTSTNPIA SIYAWTRGLA HRGKLDSTPE 350
    VTGFAETLED VVIKTVESGK MTKDLALLVG PDQPWQTTEE FLGSLDDNLA 400
    ARLA 404
    Length:404
    Mass (Da):44,769
    Last modified:August 21, 2007 - v1
    Checksum:iBA88031A67B0FAAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000750 Genomic DNA. Translation: ABS05451.1.
    RefSeqiYP_001363715.1. NC_009664.2.

    Genome annotation databases

    EnsemblBacteriaiABS05451; ABS05451; Krad_3988.
    GeneIDi5334054.
    KEGGikra:Krad_3988.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000750 Genomic DNA. Translation: ABS05451.1 .
    RefSeqi YP_001363715.1. NC_009664.2.

    3D structure databases

    ProteinModelPortali A6WF62.
    SMRi A6WF62. Positions 3-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266940.Krad_3988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS05451 ; ABS05451 ; Krad_3988 .
    GeneIDi 5334054.
    KEGGi kra:Krad_3988.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci KRAD266940:GI4N-2786-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-149 / DSM 14245 / SRS30216Imported.

    Entry informationi

    Entry nameiA6WF62_KINRD
    AccessioniPrimary (citable) accession number: A6WF62
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3