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A6WF62 (A6WF62_KINRD) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding309 – 3146NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2591NADP By similarity PIRSR PIRSR000108-4
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A6WF62 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: BA88031A67B0FAAC

FASTA40444,769
        10         20         30         40         50         60 
MAKIKVQGPV VELDGDEMTR IIWQFIKDRL VHPYLDVDLE YYDLGVEHRD ATDDQVTIDA 

        70         80         90        100        110        120 
AHAIQRAGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR NILGGVIFRE PIIISNIPRL 

       130        140        150        160        170        180 
VPGWTKPIIV GRHAYGDQYR ATDFKFPSAG TLTVTFTPED GSEPIEHEVF QAPGAGVSLS 

       190        200        210        220        230        240 
MYNLDASIVD FARSSLNYGL ARNYPVYLST KNTILKAYDG RFKDIFEEVF ENEFKDRFAE 

       250        260        270        280        290        300 
AGITYEHRLI DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLSTPDGS 

       310        320        330        340        350        360 
VVEAEAAHGT VTRHYRQHQQ GKPTSTNPIA SIYAWTRGLA HRGKLDSTPE VTGFAETLED 

       370        380        390        400 
VVIKTVESGK MTKDLALLVG PDQPWQTTEE FLGSLDDNLA ARLA 

« Hide

References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000750 Genomic DNA. Translation: ABS05451.1.
RefSeqYP_001363715.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6WF62.
SMRA6WF62. Positions 3-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266940.Krad_3988.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS05451; ABS05451; Krad_3988.
GeneID5334054.
KEGGkra:Krad_3988.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAKNTIMKV.
OrthoDBEOG628F3X.

Enzyme and pathway databases

BioCycKRAD266940:GI4N-2786-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6WF62_KINRD
AccessionPrimary (citable) accession number: A6WF62
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)