Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

Krad_3988

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Sitei139Critical for catalysisUniRule annotation1
Sitei211Critical for catalysisUniRule annotation1
Metal bindingi251Magnesium or manganeseUniRule annotation1
Binding sitei259NADPUniRule annotation1
Metal bindingi274Magnesium or manganeseUniRule annotation1
Binding sitei327NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 77NADPUniRule annotation3
Nucleotide bindingi309 – 314NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciKRAD266940:GI4N-2773-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Krad_3988Imported
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)Imported
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaKineosporialesKineosporiaceaeKineococcus
Proteomesi
  • UP000001116 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_3988.

Structurei

3D structure databases

ProteinModelPortaliA6WF62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 395Iso_dhInterPro annotationAdd BLAST387

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 100Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5N. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000019858.
KOiK00031.
OMAiAMGMYNQ.
OrthoDBiPOG091H0JP0.

Family and domain databases

InterProiView protein in InterPro
IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00470. IDH_IMDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A6WF62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIKVQGPV VELDGDEMTR IIWQFIKDRL VHPYLDVDLE YYDLGVEHRD
60 70 80 90 100
ATDDQVTIDA AHAIQRAGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR
110 120 130 140 150
NILGGVIFRE PIIISNIPRL VPGWTKPIIV GRHAYGDQYR ATDFKFPSAG
160 170 180 190 200
TLTVTFTPED GSEPIEHEVF QAPGAGVSLS MYNLDASIVD FARSSLNYGL
210 220 230 240 250
ARNYPVYLST KNTILKAYDG RFKDIFEEVF ENEFKDRFAE AGITYEHRLI
260 270 280 290 300
DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLSTPDGS
310 320 330 340 350
VVEAEAAHGT VTRHYRQHQQ GKPTSTNPIA SIYAWTRGLA HRGKLDSTPE
360 370 380 390 400
VTGFAETLED VVIKTVESGK MTKDLALLVG PDQPWQTTEE FLGSLDDNLA

ARLA
Length:404
Mass (Da):44,769
Last modified:August 21, 2007 - v1
Checksum:iBA88031A67B0FAAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS05451.1.
RefSeqiWP_012086263.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS05451; ABS05451; Krad_3988.
KEGGikra:Krad_3988.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA6WF62_KINRD
AccessioniPrimary (citable) accession number: A6WF62
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported