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A6WDL7

- SYL_KINRD

UniProt

A6WDL7 - SYL_KINRD

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Protein

Leucine--tRNA ligase

Gene
leuS, Krad_3443
Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKRAD266940:GI4N-3344-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Krad_3443
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus
ProteomesiUP000001116: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 855855Leucine--tRNA ligaseUniRule annotationPRO_0000334765Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_3443.

Structurei

3D structure databases

ProteinModelPortaliA6WDL7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi71 – 8111"HIGH" regionUniRule annotationAdd
BLAST
Motifi620 – 6245"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6WDL7-1 [UniParc]FASTAAdd to Basket

« Hide

MRDARTHRED EMTQTDTQAT GPDRAEEQDG QRYDAFALQE KWLPVWDERK    50
PFRSGEPGDE RPKKYVLDMF PYPSGDLHMG HAEAYALGDV IARYWLQRGF 100
DVMHPIGWDA FGLPAENAAI KRGLDPRRWT YDNIAQQRAS MRRYACSFDW 150
DRVLHTSDPE YYRWNQWLFL KLYEKGLAYR KDSLVNWDPV DQTVLANEQV 200
LPDGTSERSG AKVVKKKLTQ WYFRITEYAD RLLDDLDTLE GQWPAKVISM 250
QRNWIGRSTG AEVEFAIEGR DEPVTVYTTR PDTLHGATFM VVAADSDLAE 300
ELAAGAPDDV RAAFEAYRTQ VQETSDIDRL SSEREKTGVP LGRYAVNPVN 350
GERLPIWAAD YVLADYGTGA IMAVPAHDQR DLDFARAFGL PVRVVVDVRD 400
DDGNPLPDPA ESGTATAGDG VLVNSGALDG LGKQAGIAKA IEDLTAAGKG 450
RAAKNYRLRD WLISRQRYWG TPIPVVHTEN GEVPVPEDQL PVLLPPSEGL 500
NLTPKGTSPL GAAEDWVNVP SPVDGSPARR DPDTMDTFVD SSWYFLRFVS 550
PHDDTKAFDT DLIAQWGPVD QYVGGVTHAI LHLLYARFIT KVLHDLGYLP 600
FDEPFTRLLN QGMVQMDGSA MSKSKGNIVR LSDQLEEHGV DAIRLTMAFA 650
GPPEDDIDWA DVSPSGSAKF LGRAWRLARD VTSEPGVDPT TGDAALRSVT 700
HRTLHEVSQH VEAFRFNVAV ARLMELVNAT RKAIDSGPGA GDPAVREAVE 750
ATAVVLSLFA PYAAEDMWSL LGHDPCVARA GWPAVDESLL VQDTVTCVVQ 800
VQGKVRDRLE VSPDITQDAL RELALASEKV QAALGGRDLR TVVVRAPKLV 850
NIVPA 855
Length:855
Mass (Da):94,721
Last modified:August 21, 2007 - v1
Checksum:i1FC3E953BCA4D622
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS04906.1.
RefSeqiWP_012086834.1. NC_009664.2.
YP_001363170.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS04906; ABS04906; Krad_3443.
GeneIDi5335432.
KEGGikra:Krad_3443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS04906.1 .
RefSeqi WP_012086834.1. NC_009664.2.
YP_001363170.1. NC_009664.2.

3D structure databases

ProteinModelPortali A6WDL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266940.Krad_3443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS04906 ; ABS04906 ; Krad_3443 .
GeneIDi 5335432.
KEGGi kra:Krad_3443.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci KRAD266940:GI4N-3344-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Entry informationi

Entry nameiSYL_KINRD
AccessioniPrimary (citable) accession number: A6WDL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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