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A6WDL7

- SYL_KINRD

UniProt

A6WDL7 - SYL_KINRD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei623 – 6231ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciKRAD266940:GI4N-3344-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Krad_3443
    OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
    Taxonomic identifieri266940 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus
    ProteomesiUP000001116: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 855855Leucine--tRNA ligasePRO_0000334765Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266940.Krad_3443.

    Structurei

    3D structure databases

    ProteinModelPortaliA6WDL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi71 – 8111"HIGH" regionAdd
    BLAST
    Motifi620 – 6245"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6WDL7-1 [UniParc]FASTAAdd to Basket

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    MRDARTHRED EMTQTDTQAT GPDRAEEQDG QRYDAFALQE KWLPVWDERK    50
    PFRSGEPGDE RPKKYVLDMF PYPSGDLHMG HAEAYALGDV IARYWLQRGF 100
    DVMHPIGWDA FGLPAENAAI KRGLDPRRWT YDNIAQQRAS MRRYACSFDW 150
    DRVLHTSDPE YYRWNQWLFL KLYEKGLAYR KDSLVNWDPV DQTVLANEQV 200
    LPDGTSERSG AKVVKKKLTQ WYFRITEYAD RLLDDLDTLE GQWPAKVISM 250
    QRNWIGRSTG AEVEFAIEGR DEPVTVYTTR PDTLHGATFM VVAADSDLAE 300
    ELAAGAPDDV RAAFEAYRTQ VQETSDIDRL SSEREKTGVP LGRYAVNPVN 350
    GERLPIWAAD YVLADYGTGA IMAVPAHDQR DLDFARAFGL PVRVVVDVRD 400
    DDGNPLPDPA ESGTATAGDG VLVNSGALDG LGKQAGIAKA IEDLTAAGKG 450
    RAAKNYRLRD WLISRQRYWG TPIPVVHTEN GEVPVPEDQL PVLLPPSEGL 500
    NLTPKGTSPL GAAEDWVNVP SPVDGSPARR DPDTMDTFVD SSWYFLRFVS 550
    PHDDTKAFDT DLIAQWGPVD QYVGGVTHAI LHLLYARFIT KVLHDLGYLP 600
    FDEPFTRLLN QGMVQMDGSA MSKSKGNIVR LSDQLEEHGV DAIRLTMAFA 650
    GPPEDDIDWA DVSPSGSAKF LGRAWRLARD VTSEPGVDPT TGDAALRSVT 700
    HRTLHEVSQH VEAFRFNVAV ARLMELVNAT RKAIDSGPGA GDPAVREAVE 750
    ATAVVLSLFA PYAAEDMWSL LGHDPCVARA GWPAVDESLL VQDTVTCVVQ 800
    VQGKVRDRLE VSPDITQDAL RELALASEKV QAALGGRDLR TVVVRAPKLV 850
    NIVPA 855
    Length:855
    Mass (Da):94,721
    Last modified:August 21, 2007 - v1
    Checksum:i1FC3E953BCA4D622
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000750 Genomic DNA. Translation: ABS04906.1.
    RefSeqiWP_012086834.1. NC_009664.2.
    YP_001363170.1. NC_009664.2.

    Genome annotation databases

    EnsemblBacteriaiABS04906; ABS04906; Krad_3443.
    GeneIDi5335432.
    KEGGikra:Krad_3443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000750 Genomic DNA. Translation: ABS04906.1 .
    RefSeqi WP_012086834.1. NC_009664.2.
    YP_001363170.1. NC_009664.2.

    3D structure databases

    ProteinModelPortali A6WDL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266940.Krad_3443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS04906 ; ABS04906 ; Krad_3443 .
    GeneIDi 5335432.
    KEGGi kra:Krad_3443.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci KRAD266940:GI4N-3344-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

    Entry informationi

    Entry nameiSYL_KINRD
    AccessioniPrimary (citable) accession number: A6WDL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3