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A6WDB9 (A6WDB9_KINRD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Krad_3344
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP] EMBL ABS04808.1
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region274 – 2785ACP-binding By similarity HAMAP MF_01815

Sites

Active site1211 By similarity HAMAP MF_01815
Active site2731 By similarity HAMAP MF_01815
Active site3041 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A6WDB9 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 54CC550F4FAAC53C

FASTA34836,065
        10         20         30         40         50         60 
MTALTAAPTR EARILGVGAH RPPRVIDNEE VCTWIDSSDE WIQQRTGIRT RRWAAPDVSV 

        70         80         90        100        110        120 
VDMSEDAGAK ALAAAGLTGS DVDAVVLATV SYPFQTPAAA AVVAHRLGAT PAAAFDVSAG 

       130        140        150        160        170        180 
CAGFCHGVAL GSDLVRGGTA RNVLVIGAEK LSDFTDQHDR STAFLFADGA GAVVIGASDE 

       190        200        210        220        230        240 
PGIGPTVWGS DGGQADLIKS KFSWLDLRSS SGDAALAAED PAEVGEDVER WPFLEQQGQS 

       250        260        270        280        290        300 
VFRWAVWQMA PVAQAAMDAA GVTAEDLDVF VAHQANGRII DAMVKQLKLP ESVHVARDIV 

       310        320        330        340 
DMGNTSAASV PLAMERAVAD GHAPSGGLAL LIGYGAGLSY AAQVVRLP

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References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS04808.1.
RefSeqYP_001363072.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6WDB9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6WDB9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5337594.
GenomeReviewsGene locus Krad_3344 in contig CP000750_GR.
KEGGkra:Krad_3344.
NMPDRfig|266940.1.peg.2590.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMASNCFIFA.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 3 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6WDB9_KINRD
AccessionPrimary (citable) accession number: A6WDB9
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info