A6WCT0 (ARLY_KINRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Krad_3155

Organism

Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP]

Taxonomic identifier

266940 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Argininosuccinate lyase HAMAP MF_00006		PRO_0000335826

Sequences

	Sequence		Length	Mass (Da)
	A6WCT0 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: A5A4A02356EEE3A2	FASTA	481	51,195
	10 20 30 40 50 60 MTQSTDPQGE KGLWGARFAS GPATAMAALS KSTHFDFRLA RYDLAGSRAH ARVLHAAGLL 70 80 90 100 110 120 DDDVLTALLA GLDALEADVV SGAFVPAEED EDVHSALERA LVERVGADVG GRLRAGRSRN 130 140 150 160 170 180 DQIATLLRMF LRDHARVVAG LVLDVVEALL TQAAAHPGAA MPGRTHLQHA QPVLLGHHLM 190 200 210 220 230 240 AHAWPLLRDV ERLRDWDARA AVSPYGSGAL AGSSLGLDPV AVARELGFTR SVENSIDGTA 250 260 270 280 290 300 SRDVAAEFAF VAAMIGVDLS RISEEVIAWA TKEFSFVTLD DAWSTGSSIM PQKKNPDVAE 310 320 330 340 350 360 LARGKAGRLI GDLTGLLATL KGLPLAYNRD LQEDKEPVFD AVDTLEVLLP AVAGMVATLH 370 380 390 400 410 420 FHTDRMASLA PQGFALATDI AEWLVRRGVP FRDAHRISGA CVRRCEERAI AEGRGVELWD 430 440 450 460 470 480 LTVEDLAAIS PHLAPAVRDV LSTEGSLSSR DGIGGTAPVR VAEQLEAAQD ALAAHLAWAR P

References

[1]

"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000750 Genomic DNA. Translation: ABS04619.1.
RefSeq	YP_001362883.1. NC_009664.2.
3D structure databases
ProteinModelPortal	A6WCT0.
ModBase	Search...
Protein-protein interaction databases
STRING	A6WCT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5334799.
GenomeReviews	Gene locus Krad_3155 in contig CP000750_GR.
KEGG	kra:Krad_3155.
NMPDR	fig|266940.1.peg.2477.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MPGRTHL.
ProtClustDB	CLSK2516965.
Enzyme and pathway databases
BioCyc	KRAD266940:KRAD_3155-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_KINRD

Accession

Primary (citable) accession number: A6WCT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program