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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (Krad_2959)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei47SubstrateUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Binding sitei167SubstrateUniRule annotation1
Binding sitei217ATPUniRule annotation1
Binding sitei312ATP; via carbonyl oxygenUniRule annotation1
Binding sitei343ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi369 – 372ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Krad_2930
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaKineosporialesKineosporiaceaeKineococcus
Proteomesi
  • UP000001116 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000765911 – 412Phosphoglycerate kinaseAdd BLAST412

Proteomic databases

PRIDEiA6WC55

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266940.Krad_2930

Structurei

3D structure databases

ProteinModelPortaliA6WC55
SMRiA6WC55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni70 – 73Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A6WC55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLDDLETQ LGGFAGRRVL VRSDLNVPLD HDRRDGAGQP VITDDGRLRA
60 70 80 90 100
SVPTLRRLLD AGARVVVTAH LGRPKGAPEA KYSLAPVHAR LAELLPGVEV
110 120 130 140 150
GFCPVTVGAQ ATAAVDALAD GELLLLENIR FNAGETSKDD EEREAFADEL
160 170 180 190 200
AALADAFVSD GFGAVHRKHA SVYDVALRLP HAAGGLVATE VEVLQRLTAH
210 220 230 240 250
PERPYAVVLG GSKVSDKLGV IDNLLGSLLG EGDRLLVGGG MVFTFLKAQG
260 270 280 290 300
YEVGKSLLET DQLDRVAGYV RTAREKGVEL VLPTDVVAAT AFAADAEHDV
310 320 330 340 350
VAVDAIPADR LGLDIGPDSG AAFAARLADA RTVFWNGPMG VFEMEPYSHG
360 370 380 390 400
TRAVAQALVD GGAFSVVGGG DSAAAVRTLG FADERFGHIS TGGGASLEYL
410
EGKHLPGLDV LS
Length:412
Mass (Da):43,035
Last modified:August 21, 2007 - v1
Checksum:iF351D3DB5ACE7DE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA Translation: ABS04394.1
RefSeqiWP_012087360.1, NC_009664.2

Genome annotation databases

EnsemblBacteriaiABS04394; ABS04394; Krad_2930
KEGGikra:Krad_2930

Similar proteinsi

Entry informationi

Entry nameiPGK_KINRD
AccessioniPrimary (citable) accession number: A6WC55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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