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A6W915 (UPPP_KINRD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Krad_1818
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP]
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000083980

Regions

Transmembrane90 – 11021Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane257 – 27721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6W915 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 92C862C384F7948D

FASTA28129,807
        10         20         30         40         50         60 
MSMGIVEGAF LGLVQGLTEF LPISSSGHLA VVGTLLGSDP GAAFTAICQL GTEAAVIGYF 

        70         80         90        100        110        120 
RKDIARIIGH WARSLVGRLP RNDPDARMGW LVTLGTIPIG VLGLLFQDSI ETVLRGFVVI 

       130        140        150        160        170        180 
GTTLWLFALV LGAADRFGRK ERTLDQLSWK HGLLFGLAQA LALIPGVSRS GGTITMGLLL 

       190        200        210        220        230        240 
GYTREAAARY SFLLAIPAVV LSGFYQLYDE LSRGTTIAWV PTAVATVVAF VVGYAVIAWL 

       250        260        270        280 
MRFISTHSYT PFVVYRIAAA VVVYALVLAG ALPAFQGTGG S 

« Hide

References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000750 Genomic DNA. Translation: ABS03304.1.
RefSeqYP_001361568.1. NC_009664.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266940.Krad_1818.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS03304; ABS03304; Krad_1818.
GeneID5337133.
KEGGkra:Krad_1818.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycKRAD266940:GI4N-406-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_KINRD
AccessionPrimary (citable) accession number: A6W915
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families