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A6W8D2 (A6W8D2_KINRD) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP MF_00218
Short name=UPD HAMAP MF_00218
Short name=URO-D HAMAP MF_00218
EC=4.1.1.37 HAMAP MF_00218
Gene names
Name:hemE HAMAP MF_00218
Ordered Locus Names:Krad_1585
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP] EMBL ABS03071.1
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP MF_00218

Ontologies

Keywords
   Biological processPorphyrin biosynthesis HAMAP MF_00218
   Cellular componentCytoplasm HAMAP MF_00218
   Molecular functionDecarboxylase HAMAP MF_00218
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region27 – 315Substrate binding By similarity HAMAP MF_00218

Sites

Binding site761Substrate By similarity HAMAP MF_00218
Binding site1551Substrate By similarity HAMAP MF_00218
Binding site2101Substrate By similarity HAMAP MF_00218
Binding site3311Substrate By similarity HAMAP MF_00218
Site761Transition state stabilizer By similarity HAMAP MF_00218

Sequences

Sequence LengthMass (Da)Tools
A6W8D2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 13F1E9939F58C9D1

FASTA35437,095
        10         20         30         40         50         60 
MPLENSAYLH AARGGTTPRR TPVWFMRQAG RSLPEYREAR AGTTMLESCR IPELVAEITL 

        70         80         90        100        110        120 
QPVRRYDVDA AVFYSDIVVP LEAAGVGVEI VAGTGPVIAE PFRTRADLDR LPELSLDALQ 

       130        140        150        160        170        180 
HVTDAVALTT AQLAGIGDGV PLIGFAGAPF TLASYLVEGG PSRDLLRTKA LMHADPQLWH 

       190        200        210        220        230        240 
DLAARLAQIA GTFLRAQVLA GASAVQLFDS WVGALPLADY ERLVAPHSSA ALAAVSDLGV 

       250        260        270        280        290        300 
PRTHFGTGTG ELLGAMAAVD GGVDVLGVDF RVPLDVGAAR GAAGAGRPVA VQGNLDPALL 

       310        320        330        340        350 
FAPWDVLRAD LHRILAEGER AGGGHVVNLG HGVPPTADPA VLARVVEEVH AWRS

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References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS03071.1.
RefSeqYP_001361335.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6W8D2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6W8D2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5335460.
GenomeReviewsGene locus Krad_1585 in contig CP000750_GR.
KEGGkra:Krad_1585.
NMPDRfig|266940.1.peg.2828.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.

Family and domain databases

HAMAPMF_00218. URO_D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6W8D2_KINRD
AccessionPrimary (citable) accession number: A6W8D2
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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