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A6W8C5 (A6W8C5_KINRD) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase 2 HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 2 HAMAP MF_00315
Gene names
Name:dxs2 HAMAP MF_00315
Ordered Locus Names:Krad_1578
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP] EMBL ABS03064.1
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
A6W8C5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 8A1F2FB8ED92C72B

FASTA64367,836
        10         20         30         40         50         60 
MGLLETIKGP QDLKSLPAEE LPALAEEVRA FLVDAVSRTG GHLGPNLGVV ELTIALHRVF 

        70         80         90        100        110        120 
DSPRDRLVLD TGHQSYVHKL LTGRQDFSRL REAGGLAGYP SRAESEHDVV ENSHASTSLS 

       130        140        150        160        170        180 
WADGLAKAFE LRGESQGEHG RRVVAVIGDG ALTGGMAWEA LNNIADAQRP VIVVVNDNER 

       190        200        210        220        230        240 
SYAPTTGGMA SHLATLRTTR EYEKLLDWGK QSLKRGGTPG RLAHATLHGV KKGLKDIVAP 

       250        260        270        280        290        300 
QGLFEDLGLK YVGPVDGHDT EAVEHALRRA RSFGGPVIVH VITQKGRGYQ PALADDADRF 

       310        320        330        340        350        360 
HAVGVIDPET GEAQATSGSS WTSVFADEVL AIADERPDVV GVTAAMRAPV GLEPFARAHP 

       370        380        390        400        410        420 
ERVFDVGIAE QHAVTSAAGM AAGGLHPVVA VYATFLNRAF DQLLLDVGLH RAGVTLVLDR 

       430        440        450        460        470        480 
AGVTGPDGPS HHGVWDLGLC RLVPGLRLAA PRDAATLRAE LREAVDVDDA PTVLRFSKGK 

       490        500        510        520        530        540 
VPAAIPAIAR TGHADVLEGP AWAQGDDVLL VAVGALVTRA LDVAARLRAH GVGVTVVDPR 

       550        560        570        580        590        600 
WVVPVDEALV DLARSHRHVA VLEDGGEVGG VGWALAAGLR ERDDATPVHG FALPQRFLDV 

       610        620        630        640 
GARDALLDEA GLAPQDVARA LVEAVARTGQ PERPGPSAAV PPR

« Hide

References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS03064.1.
RefSeqYP_001361328.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6W8C5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6W8C5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5335114.
GenomeReviewsGene locus Krad_1578 in contig CP000750_GR.
KEGGkra:Krad_1578.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAQYDISYM.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6W8C5_KINRD
AccessionPrimary (citable) accession number: A6W8C5
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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