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A6W828 (DAPA_KINRD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:Krad_1479
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP]
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000340959

Regions

Region59 – 602Pyruvate binding By similarity

Sites

Active site1721Schiff-base intermediate with substrate By similarity
Binding site1171Pyruvate By similarity
Site1441Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
A6W828 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 697E4CA96F68E6A2

FASTA30831,551
        10         20         30         40         50         60 
MPTATAAQPL RPFGTVLSAV VTPFTASGAV DLDAAAALAV HLVEHGHDGL VVSGTTGESP 

        70         80         90        100        110        120 
TTSDEEKDRL LRAVLDAVGD RVHVLAGVGT NDTAHTLELA RAAEKAGAHG LLVVTPYYNK 

       130        140        150        160        170        180 
PPQAALAHHF TTVADGTGLP VMLYDIPGRS GVPIETETLV RVAEHERIVA VKDAKGDSWG 

       190        200        210        220        230        240 
TSWVLARTEL AYYSGDDAVN LPLLAQGASG IVSVVSHVAG REYAAMVAAV DAGDLVTARA 

       250        260        270        280        290        300 
IHTRLLPAVR GIMTRTQGVV AVKAALELTG VLSGRAVRPP LLPATPEEVA ALAADLALAG 


LAPAPLDA

« Hide

References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS02967.1.
RefSeqYP_001361231.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6W828.
SMRA6W828. Positions 12-301.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6W828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5334282.
GenomeReviewsGene locus Krad_1479 in contig CP000750_GR.
KEGGkra:Krad_1479.
NMPDRfig|266940.1.peg.4790.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0329.
HOGENOMHBG358848.
OMAHGCISVV.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycKRAD266940:KRAD_1479-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_KINRD
AccessionPrimary (citable) accession number: A6W828
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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