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A6W815

- PNP_KINRD

UniProt

A6W815 - PNP_KINRD

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, Krad_1466
Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi520 – 5201Magnesium By similarity
Metal bindingi526 – 5261Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciKRAD266940:GI4N-759-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Krad_1466
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus
ProteomesiUP000001116: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329686Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_1466.

Structurei

3D structure databases

ProteinModelPortaliA6W815.
SMRiA6W815. Positions 5-723.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini586 – 64863KHAdd
BLAST
Domaini657 – 72973S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6W815-1 [UniParc]FASTAAdd to Basket

« Hide

MEGPEITAAE AVIDNGSFGT RTIRFETGRL AKQAAGSAAV YLDGESFLLS    50
ATTAGKSPKD QFDFFPLTVD VEERSYAAGK IPGSFFRREG RPSTEAILTC 100
RLIDRPLRPS FVKGLRNEVQ VVVSVMALHP DDAYDVVAIN VASLSTQLSG 150
LPFSGPIGGV RIALIDGQWV AFPRYSELER AVFDMVVAGR VVTTADGSQD 200
VAIMMVEAEA TEGSWNLIKD QGATAPTEEV VAAGLEAAKP FIAELVRAQA 250
EVAATAAKPT AAFPTFPDYQ DDVYQAVFEA ASADLTAALQ IGGKQDRETR 300
IDEVKEAVKA QLADAFAGRE KEVSAAYRSV QKALIRQRVL KDGVRIDGRG 350
LADIRTLSAE VEVLPRVHGS ALFERGETQI LGVTTLNMLR MEQQLDTLSP 400
VTRKRYMHNY NFPPYSTGET GRVGSPKRRE IGHGALAERA LVPVLPARED 450
FPYAIRQVSE ALGSNGSTSM GSVCASTLSL LNAGVPLRAA VAGIAMGLIS 500
DTVDGETRYA ALTDILGAED AFGDMDFKVA GTKEFVTAIQ LDTKLDGIPA 550
SVLAGALTQA RDARLHILDV MAEAIDAPDE MSPTAPRIIT VKVPVDKIGE 600
VIGPKGKMIN QIQEDTGADI SIEDDGTVFI GAVDGPSAEA ARAAVNAIAN 650
PTMPEVGERY LGTVVKTTTF GAFVSLMPGK DGLLHISQLR KLSGGKRVDN 700
VEDVVAVGQK VQVEIAEIDP RGKLSLVPVV AEEASAEAAA AEPADA 746
Length:746
Mass (Da):79,078
Last modified:August 21, 2007 - v1
Checksum:i0DAAFC8956295C99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS02954.1.
RefSeqiWP_011981907.1. NC_009664.2.
YP_001361218.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS02954; ABS02954; Krad_1466.
GeneIDi5333837.
KEGGikra:Krad_1466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS02954.1 .
RefSeqi WP_011981907.1. NC_009664.2.
YP_001361218.1. NC_009664.2.

3D structure databases

ProteinModelPortali A6W815.
SMRi A6W815. Positions 5-723.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266940.Krad_1466.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS02954 ; ABS02954 ; Krad_1466 .
GeneIDi 5333837.
KEGGi kra:Krad_1466.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci KRAD266940:GI4N-759-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Entry informationi

Entry nameiPNP_KINRD
AccessioniPrimary (citable) accession number: A6W815
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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