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A6W6Z0 (A6W6Z0_KINRD) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase HAMAP MF_01401
Gene names
Name:msrA HAMAP MF_01401
Ordered Locus Names:Krad_1091
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP] EMBL ABS02579.1
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401

Catalytic activity

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
   Molecular functionOxidoreductase HAMAP MF_01401 EMBL ABS02579.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein modification process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionpeptide-methionine-(S)-S-oxide reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site561 By similarity HAMAP MF_01401

Sequences

Sequence LengthMass (Da)Tools
A6W6Z0 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: D51760948F906915

FASTA22324,947
        10         20         30         40         50         60 
MLFGNPYKTT MVTADQALRG SATRRFEVPA THAVLGTPLE GPWPEGTEVI SFAMGCYWGA 

        70         80         90        100        110        120 
ERIFWRQPGV VTTAAGFQGG FTENPTYEES TTGRTGHAET VLVAYDPTAT SAEQLLKIFW 

       130        140        150        160        170        180 
ENHDPTQGYR QGNDRGTEYR SAVYTTTDEQ WEAAQRTRET FQRELTEHGH GRITTEIRRA 

       190        200        210        220 
SEAGPFWYAE DYHQQYLEKV PNGYCNHGPN GLTCQIGLVP AAE

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References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS02579.1.
RefSeqYP_001360843.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6W6Z0.
SMRA6W6Z0. Positions 12-214.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6W6Z0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5337409.
GenomeReviewsGene locus Krad_1091 in contig CP000750_GR.
KEGGkra:Krad_1091.
NMPDRfig|266940.1.peg.3128.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0225.
HOGENOMHBG748152.
OMASAIYCTT.

Family and domain databases

HAMAPMF_01401. MsrA.
[Tree]
InterProIPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
KOK07304.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6W6Z0_KINRD
AccessionPrimary (citable) accession number: A6W6Z0
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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