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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei189DesacetylmycothiolUniRule annotation1
Binding sitei228DesacetylmycothiolUniRule annotation1
Binding sitei235DesacetylmycothiolUniRule annotation1
Binding sitei272Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Krad_0878
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaKineosporialesKineosporiaceaeKineococcus
Proteomesi
  • UP000001116 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002611 – 303Mycothiol acetyltransferaseAdd BLAST303

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266940.Krad_0878.

Structurei

3D structure databases

ProteinModelPortaliA6W6C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 156N-acetyltransferase 1UniRule annotationAdd BLAST147
Domaini162 – 303N-acetyltransferase 2UniRule annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 88Acetyl-CoA binding 1UniRule annotation3
Regioni239 – 241Acetyl-CoA binding 2UniRule annotation3
Regioni246 – 252Acetyl-CoA binding 2UniRule annotation7
Regioni277 – 282Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6W6C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAPAGATA LPGPLPGDVH DAVLALAAAA SRADGATSLS EDAVLRLRAG
60 70 80 90 100
DGAVQHLVRH EDGVLAGYAQ LVPSGDGEGD GFEGELLVHP GHRRRGHGGA
110 120 130 140 150
LLAAVEERAG ARPVRLWSHG DTPGASALAA RAGWTRAREL LRMERTSAGL
160 170 180 190 200
SDLAVPDLAA GLAVRPFVPG ADDAAWVALN AAAFATHPEQ GRWTLDDLRA
210 220 230 240 250
RLAEPWFDPA LLLLAEAPDG LAAFCWMKVE DGLGELYVLG VDPARSGAGL
260 270 280 290 300
GRALLVRGLR AVAGRVDRVD LYVDGDNLRA VRLYAGLGFS RAATDVQYAS

GPR
Length:303
Mass (Da):31,420
Last modified:August 21, 2007 - v1
Checksum:iDFA7D175E942AF22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS02366.1.

Genome annotation databases

EnsemblBacteriaiABS02366; ABS02366; Krad_0878.
KEGGikra:Krad_0878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS02366.1.

3D structure databases

ProteinModelPortaliA6W6C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266940.Krad_0878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS02366; ABS02366; Krad_0878.
KEGGikra:Krad_0878.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_KINRD
AccessioniPrimary (citable) accession number: A6W6C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.