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A6W6A1 (THIM_KINRD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Krad_0852
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP]
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383868

Sites

Binding site531Substrate; via amide nitrogen By similarity
Binding site1281ATP By similarity
Binding site1741ATP By similarity
Binding site2011Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A6W6A1 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 1369D1AEADA16080

FASTA27527,435
        10         20         30         40         50         60 
MSAVAPHPVP APALAAARAA LTERAPLVQC LTNSVVQTIT ANALLAAGAA PAMVDNVHES 

        70         80         90        100        110        120 
AAFAQIASAV LVNVGTLDDD RARAMGLAAQ SADRSRTPWV LDPVAVGGLE FRTRVARDLL 

       130        140        150        160        170        180 
ASSPTVVRGN ASEVLGLAGA GSGGRGVDST AGAEEAVEAA RELSRRTGGA VAVSGVVDVL 

       190        200        210        220        230        240 
VHDGRTLRVS GGHVLLTRTT GAGCSLGALV AAYAAVEDDP LVAAAAAHVH VAIAAERAAA 

       250        260        270 
RAARPGSFAT AWIDELDAVD ADAVRADLET SGRLA 

« Hide

References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000750 Genomic DNA. Translation: ABS02340.1.
RefSeqYP_001360604.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6W6A1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266940.Krad_0852.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS02340; ABS02340; Krad_0852.
GeneID5337177.
KEGGkra:Krad_0852.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG6W9X41.

Enzyme and pathway databases

BioCycKRAD266940:GI4N-1382-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_KINRD
AccessionPrimary (citable) accession number: A6W6A1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways