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A6W6A1

- THIM_KINRD

UniProt

A6W6A1 - THIM_KINRD

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, Krad_0852
Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Substrate; via amide nitrogen By similarity
Binding sitei128 – 1281ATP By similarity
Binding sitei174 – 1741ATP By similarity
Binding sitei201 – 2011Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKRAD266940:GI4N-1382-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:Krad_0852
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesKineosporiineaeKineosporiaceaeKineococcus
ProteomesiUP000001116: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000383868Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_0852.

Structurei

3D structure databases

ProteinModelPortaliA6W6A1.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG6W9X41.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

A6W6A1-1 [UniParc]FASTAAdd to Basket

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MSAVAPHPVP APALAAARAA LTERAPLVQC LTNSVVQTIT ANALLAAGAA    50
PAMVDNVHES AAFAQIASAV LVNVGTLDDD RARAMGLAAQ SADRSRTPWV 100
LDPVAVGGLE FRTRVARDLL ASSPTVVRGN ASEVLGLAGA GSGGRGVDST 150
AGAEEAVEAA RELSRRTGGA VAVSGVVDVL VHDGRTLRVS GGHVLLTRTT 200
GAGCSLGALV AAYAAVEDDP LVAAAAAHVH VAIAAERAAA RAARPGSFAT 250
AWIDELDAVD ADAVRADLET SGRLA 275
Length:275
Mass (Da):27,435
Last modified:August 21, 2007 - v1
Checksum:i1369D1AEADA16080
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS02340.1.
RefSeqiWP_012084812.1. NC_009664.2.
YP_001360604.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS02340; ABS02340; Krad_0852.
GeneIDi5337177.
KEGGikra:Krad_0852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000750 Genomic DNA. Translation: ABS02340.1 .
RefSeqi WP_012084812.1. NC_009664.2.
YP_001360604.1. NC_009664.2.

3D structure databases

ProteinModelPortali A6W6A1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266940.Krad_0852.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS02340 ; ABS02340 ; Krad_0852 .
GeneIDi 5337177.
KEGGi kra:Krad_0852.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG6W9X41.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci KRAD266940:GI4N-1382-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Entry informationi

Entry nameiTHIM_KINRD
AccessioniPrimary (citable) accession number: A6W6A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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