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A6W5Z9 (A6W5Z9_KINRD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP-Rule MF_00344
EC=6.3.5.2 HAMAP-Rule MF_00344
Alternative name(s):
GMP synthetase HAMAP-Rule MF_00344
Glutamine amidotransferase HAMAP-Rule MF_00344
Gene names
Name:guaA HAMAP-Rule MF_00344
Ordered Locus Names:Krad_0749 EMBL ABS02238.1
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP] EMBL ABS02238.1
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus ›

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP-Rule MF_00344 SAAS SAAS022955

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP-Rule MF_00344 SAAS SAAS022955

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence similarities

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain30 – 222193Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00344
Domain223 – 421199GMPS ATP-PPase By similarity HAMAP-Rule MF_00344
Nucleotide binding250 – 2567ATP By similarity HAMAP-Rule MF_00344

Sites

Active site1071Nucleophile By similarity HAMAP-Rule MF_00344
Active site1961 By similarity HAMAP-Rule MF_00344
Active site1981 By similarity HAMAP-Rule MF_00344

Sequences

Sequence LengthMass (Da)Tools
A6W5Z9 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: CABBFC70116E72F6

FASTA54758,403
        10         20         30         40         50         60 
MVTPDAPETQ VETTPDTRPA EVEAERAHRP VLVVDYGAQY AQLIARRVRE ADTYSEIVPS 

        70         80         90        100        110        120 
STPVAEILAK DPAAVILSGG PSSVYAEGAP QVDPALFEAG VPVLGICYGF QAMAKALGGE 

       130        140        150        160        170        180 
VARTGQREYG GTAAALPNAA ESTLLRDQPA EQPVWMSHGD SVSRAPEGFR VTASTDGTPV 

       190        200        210        220        230        240 
AAFEDDERRL YGVQWHPEVK HSTHGQDVLV NFLRHGAGID PDWTTGNVIE EQVARIKAQI 

       250        260        270        280        290        300 
GDGKVICALS GGVDSAVAGA LVQRAVGDQL TCVFVDHGLL RAGEAEQVEK DFVAATGVKL 

       310        320        330        340        350        360 
HVVDAVQRFA DALDGVSDPE QKRKIIGREF IRVFEQAARD VVAKEGTDGG EVRFLVQGTL 

       370        380        390        400        410        420 
YPDVVESGGG TGAATIKSHH NVGGLPDDLA FELVEPLRAL FKDEVRAVGV QLGLPEAMVY 

       430        440        450        460        470        480 
RQPFPGPGLA IRIVGAVTPE RLEILRAADA IARAELTAAG LDRDIWQCPV VLLADVRSVG 

       490        500        510        520        530        540 
VQGDGRTYGH PVVLRPVSSE DAMTADWTRL PYDVLARIST RITNEVPEVN RVVLDVTSKP 


PGTIEWE

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References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS02238.1.
RefSeqYP_001360502.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6W5Z9.
ModBaseSearch...

Protein-protein interaction databases

STRING266940.Krad_0749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS02238; ABS02238; Krad_0749.
GeneID5337819.
KEGGkra:Krad_0749.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0519.
HOGENOMHOG000223964.
KOK01951.
OMAYDYVVAL.
ProtClustDBPRK00074.

Enzyme and pathway databases

BioCycKRAD266940:GI4N-1671-MONOMER.
UniPathwayUPA00189; UER00296.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00344. GMP_synthase.
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6W5Z9_KINRD
AccessionPrimary (citable) accession number: A6W5Z9
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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