A6W5R0 (HTPX_KINRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protease HtpX homolog
EC=3.4.24.-

Gene names

Name:	htpX
Ordered Locus Names:	Krad_0660

Organism

Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP]

Taxonomic identifier

266940 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus › Kineococcus radiotolerans

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00188.
Sequence similarities	Belongs to the peptidase M48B family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Protease HtpX homolog HAMAP-Rule MF_00188		PRO_1000077465
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	34 – 54	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential
	Transmembrane	188 – 208	21	Helical; Potential
Sites
	Active site	139	1	By similarity
	Metal binding	138	1	Zinc; catalytic By similarity
	Metal binding	142	1	Zinc; catalytic By similarity
	Metal binding	213	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6W5R0 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 67632AE25C39F981	FASTA	294	31,640
	10 20 30 40 50 60 MHRHHNGLKT AVLFGGIWGV LLLIGAFLAS SFRSPGVLLV FVVIGLATSA YSYWNSAGLA 70 80 90 100 110 120 LRAMRARPVS EAEQPGMHRI VRELSTAARQ PMPQLYVSPT MAPNAFATGR NPENAAVCCT 130 140 150 160 170 180 EGILQLLDER ELRGVLGHEL MHVYNRDILT SSVAGALAGV ITSIAQFGVF FGSALGGGRD 190 200 210 220 230 240 GEERANPLAL LLLSLMAPLA ASVIQLAISR TREYDADEDG ARLTGDPLAL ASALRKLELG 250 260 270 280 290 TRQLPLPPER ELVNSSHMMI ANPFRGQGVA RLFSTHPPMA ERIARLEALA GYRR

References

[1]

"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000750 Genomic DNA. Translation: ABS02149.1.
RefSeq	YP_001360413.1. NC_009664.2.
3D structure databases
ProteinModelPortal	A6W5R0.
ModBase	Search...
Protein-protein interaction databases
STRING	266940.Krad_0660.
Protein family/group databases
MEROPS	M48.004.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS02149; ABS02149; Krad_0660.
GeneID	5337338.
KEGG	kra:Krad_0660.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0501.
HOGENOM	HOG000227301.
KO	K03799.
OMA	AWAILAP.
ProtClustDB	PRK03072.
Enzyme and pathway databases
BioCyc	KRAD266940:GI4N-1764-MONOMER.
Family and domain databases
HAMAP	MF_00188. Peptidase_M48.
InterPro	IPR022919. Pept_M48_protease_HtpX. IPR001915. Peptidase_M48. [Graphical view]
Pfam	PF01435. Peptidase_M48. 1 hit. [Graphical view]
PROSITE	PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTPX_KINRD

Accession

Primary (citable) accession number: A6W5R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program