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Protein

Aldose 1-epimerase

Gene

Krad_0621

Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts alpha-aldose to the beta-anomer.UniRule annotation

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.UniRule annotation

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171Proton donorUniRule annotation
Binding sitei289 – 2891SubstrateUniRule annotation
Active sitei354 – 3541Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Enzyme and pathway databases

BioCyciKRAD266940:GI4N-1618-MONOMER.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimeraseUniRule annotation (EC:5.1.3.3UniRule annotation)
Alternative name(s):
Galactose mutarotaseUniRule annotation
Gene namesi
Ordered Locus Names:Krad_0621Imported
OrganismiKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)Imported
Taxonomic identifieri266940 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaKineosporialesKineosporiaceaeKineococcus
Proteomesi
  • UP000001116 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 388363Aldose 1-epimeraseSequence analysisPRO_5002701834Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266940.Krad_0621.

Structurei

3D structure databases

ProteinModelPortaliA6W5M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldose epimerase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4105ENN. Bacteria.
COG2017. LUCA.
HOGENOMiHOG000072798.
KOiK01785.
OMAiSPNHPDW.
OrthoDBiEOG69WFM5.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6W5M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLNPSRRSV VLAGAAATAL VGAAAAPAAA AVQREPRLFA EPWGTLPDGT
60 70 80 90 100
AVERWTLVDG EVTARILTYG GILQSLEFPD HRGRVRNVVL GFADLEGYLA
110 120 130 140 150
GNNPGPYFGA LIGRYGNRIA GGRFTLDGVE HQLPLNNGPN SLHGGTDSFD
160 170 180 190 200
KRVWSATPVF GDGTVGLRLS LDSPDGDQGY PGNLHVEVTY TLDRFAQLTL
210 220 230 240 250
DYLATTDAAT VVNLTNHSYW NLAGEGSGTA LDHELTIHAD GFTPVDETLI
260 270 280 290 300
PTGEIAPVAG TPMDFRSPRR IAARIRQPYQ QILFGQGYDH NWVLDRAGDG
310 320 330 340 350
LEEAAVLHDP RSGRTLRVST TEPGLQFYSG NFLDATLVGT GGGVYRQGDG
360 370 380
VALETQHFPD SPNQPDFPST VLRPGEEYRS TTVFGLSR
Length:388
Mass (Da):41,594
Last modified:August 21, 2007 - v1
Checksum:iF7297D70E1A82ECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS02110.1.
RefSeqiWP_012085048.1. NC_009664.2.

Genome annotation databases

EnsemblBacteriaiABS02110; ABS02110; Krad_0621.
KEGGikra:Krad_0621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000750 Genomic DNA. Translation: ABS02110.1.
RefSeqiWP_012085048.1. NC_009664.2.

3D structure databases

ProteinModelPortaliA6W5M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266940.Krad_0621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS02110; ABS02110; Krad_0621.
KEGGikra:Krad_0621.

Phylogenomic databases

eggNOGiENOG4105ENN. Bacteria.
COG2017. LUCA.
HOGENOMiHOG000072798.
KOiK01785.
OMAiSPNHPDW.
OrthoDBiEOG69WFM5.

Enzyme and pathway databases

UniPathwayiUPA00242.
BioCyciKRAD266940:GI4N-1618-MONOMER.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-149 / DSM 14245 / SRS30216Imported.

Entry informationi

Entry nameiA6W5M1_KINRD
AccessioniPrimary (citable) accession number: A6W5M1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 16, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.