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A6W516 (A6W516_KINRD) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123
Gene names
Name:acsA HAMAP MF_01123
Ordered Locus Names:Krad_0415
OrganismKineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP] EMBL ABS01905.1
Taxonomic identifier266940 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5221 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6141N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
A6W516 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 359488A3B6A6CED7

FASTA65470,389
        10         20         30         40         50         60 
MSTDPSTQQE PTTGSGTFAP DPEFAAGAVA RADLYDRAAA DRLGFWAEVA REHVTWDTDF 

        70         80         90        100        110        120 
DEVLDWSNPP FAKWFVGGKL NVAVNCVDRH VAAGNGERVA LHFEGEPGDT RAVTYAQLHE 

       130        140        150        160        170        180 
QVQRAANVLA GLGVRAGDRV AIYLPMLVES VVAMLACARL GAAHSVVFGG FSADALHSRI 

       190        200        210        220        230        240 
DDAQAKVVIT CDGSYRRGKP TTLKPAVDAA LAKGAPSVTG VLVVKRNGEA VDWVEGRDVW 

       250        260        270        280        290        300 
WDEALAAAAP VHEAEAFDAE NPLFVLYTSG TTGKPKGILH TSGGYLVQTA YTTRTVFDVQ 

       310        320        330        340        350        360 
PGRDVYWCTA DVGWVTGHSY VVYGPLANGL TQVIYEGTPD TPDKDRWWSL VEKYGVTVLY 

       370        380        390        400        410        420 
TAPTAIRTCM KWGEEYPARH DLSSLRVLGS VGENINPEAW SWYRRVIGAD RTPIVDTWWQ 

       430        440        450        460        470        480 
TETGAQMIAP LPGVTSLKPG SAQVPLPGIV AEVVDDAGEP VPHGQAGYLV LSEPWPAMTR 

       490        500        510        520        530        540 
GIWGDEQRFR DTYWARFPGR YFAGDGAKRD EDGDIWLLGR VDDVMNVSGH RLSTAEIESA 

       550        560        570        580        590        600 
LVSHPDVAEA AVVGATDETT GQAVVAFVIL RGGHEEGPGT VAALRDHVAK EIGPIAKPKS 

       610        620        630        640        650 
IMVVAELPKT RSGKIMRRLL RDVAEHRPTG DVTTLTDSTV MDAITAGMNA PAGD

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References

[1]"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000750 Genomic DNA. Translation: ABS01905.1.
RefSeqYP_001360169.1. NC_009664.2.

3D structure databases

ProteinModelPortalA6W516.
SMRA6W516. Positions 32-645.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6W516.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5333847.
GenomeReviewsGene locus Krad_0415 in contig CP000750_GR.
KEGGkra:Krad_0415.
NMPDRfig|266940.1.peg.2909.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMAVISVSGH.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6W516_KINRD
AccessionPrimary (citable) accession number: A6W516
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info