A6W3W0 (A6W3W0_KINRD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	Krad_0007

Organism

Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) [Complete proteome] [HAMAP] EMBL ABS01499.1

Taxonomic identifier

266940 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Kineosporiineae › Kineosporiaceae › Kineococcus

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6W3W0 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: B6A8999520C5C998	FASTA	910	100,279
	10 20 30 40 50 60 MSESTTEPPH PGDRVEQVDL QAEMQRSYLD YAMSVIVSRA LPDVRDGLKP VHRRVLYAMY 70 80 90 100 110 120 DGGYRPDRGY SKCARVVGDV MGHYHPHGDT SIYDALVRLA QDWSLRYPLV DGQGNFGSPG 130 140 150 160 170 180 NDPAAAPRYT ECRMAPLAME MVRDIDEETV DFSPNYDGHT DEPDVLPSRF PNLLVNGSAG 190 200 210 220 230 240 IAVGMATNIP PHNLREVAEG AKWLLDNPDA SDEEQLAALL TRIKGPDFPT GALILGHRGI 250 260 270 280 290 300 SDAYRTGRGS ITMRAVVEVE EIQGRTCLVV SELPYQVNPD NLAENIANLV RDGRLTGIAD 310 320 330 340 350 360 VQDHTSGKTG QRLVIILRRD AVAKVVLNNL YKHTQLQTNF GANMLALVDG VPRTLPIHAF 370 380 390 400 410 420 LKHWIAHQLD VIVRRTRFRL RKAEERAHIL RALLKALDAL DEVIALIRAS PTVESARDGL 430 440 450 460 470 480 MGLLEIDEIQ SRAILEMQLR RLAALERQRI TDEYDELMRM IGDFNDILAR PERQRQIVGD 490 500 510 520 530 540 ELAELVERYG DERKTQILPF EGDMTVEDLI PVEDVVVTVT RGGYAKRTKT DLYRAQRRGG 550 560 570 580 590 600 RGVRGASLRE DDVVEHFFTT TTHHWLLFFT NLGRVYRAKG YELPEGGRDG RGQHVANLLA 610 620 630 640 650 660 FQPGERIVAV LDIEDYEQAP YLVLATRGGI VKKTRLSEYD SNRSGGLIAI NLRSHPGADG 670 680 690 700 710 720 TEEVDDELFA ATLVSEDEDL FLVSRKGMSV RFEATDENLR PMGRATSGVT GMKFRGEDEL 730 740 750 760 770 780 LAMAVARDDL FVFVVTELGY AKRTKIEHYR KQGRGGLGIK VAKLTEERGD LVGALTVSED 790 800 810 820 830 840 DEVLVVMQAG RVVRSRVDEV PDKGRDTMGV TFARPETGDR ILAITRNVER VIDVEVEAEE 850 860 870 880 890 900 VSEATTSGVD DPIADVAGSG DDLAAAEGAD EAPIGGAPVE ERGIDPVSGA GDGVPSPEAP 910 TSEPDPGGDE

References

[1]

"Complete sequence of chromosome of Kineococcus radiotolerans SRS30216." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J., Fliermans C., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-149 / DSM 14245 / SRS30216.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000750 Genomic DNA. Translation: ABS01499.1.
RefSeq	YP_001359763.1. NC_009664.2.
3D structure databases
ProteinModelPortal	A6W3W0.
ModBase	Search...
Protein-protein interaction databases
STRING	A6W3W0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5335382.
GenomeReviews	Gene locus Krad_0007 in contig CP000750_GR.
KEGG	kra:Krad_0007.
NMPDR	fig|266940.1.peg.2654.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TGRGRIY.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6W3W0_KINRD

Accession

Primary (citable) accession number: A6W3W0

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)