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A6W351

- PROB_MARMS

UniProt

A6W351 - PROB_MARMS

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Protein

Glutamate 5-kinase

Gene

proB

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei16 – 161ATPUniRule annotation
Binding sitei56 – 561SubstrateUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Binding sitei155 – 1551Substrate; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1762ATPUniRule annotation
Nucleotide bindingi217 – 2237ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
  3. RNA binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP400668:GHKD-4338-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:Mmwyl1_4235
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Glutamate 5-kinasePRO_1000125243Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_4235.

Structurei

3D structure databases

ProteinModelPortaliA6W351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 36079PUAUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation
Contains 1 PUA domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiMRMIAGH.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6W351-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEMREKIAKA QRVVVKIGSA LLTNDGQGLD VARIGLWVAQ IAELRAQGKE
60 70 80 90 100
VVLVSSGSIA AGMKRLGFSS RPTQVNELQA AAAVGQMELV GVYESHFEKH
110 120 130 140 150
GLCTAQILLT HDDLSNRRRY LNARSSLRTL LGFGVVPIIN ENDTVVTDEI
160 170 180 190 200
RFGDNDTLGA LVANLVEADL LIILTDQQGL FDKNPRDHQD ATLISHISAS
210 220 230 240 250
DNRLESMASG GAGVLGSGGM LTKVRAALLA ARSGADTLIA SGREENVIVR
260 270 280 290 300
VASGEMMGTW LQPEHGRVAA RKQWLAGHLK SRGALILDDG AVKALRKEGT
310 320 330 340 350
SLLAVGVKDA QGTFSRGDMV VCVDLQGGLV ARGLVNYSVA ETLKLLGQPS
360 370
SNIGAILGYK GEPELIHRDD LVII
Length:374
Mass (Da):39,810
Last modified:August 21, 2007 - v1
Checksum:iBB843E5F4101381C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR73130.1.
RefSeqiWP_012071895.1. NC_009654.1.
YP_001343065.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR73130; ABR73130; Mmwyl1_4235.
GeneIDi5367722.
KEGGimmw:Mmwyl1_4235.
PATRICi22472159. VBIMarSp124341_4391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR73130.1 .
RefSeqi WP_012071895.1. NC_009654.1.
YP_001343065.1. NC_009654.1.

3D structure databases

ProteinModelPortali A6W351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400668.Mmwyl1_4235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR73130 ; ABR73130 ; Mmwyl1_4235 .
GeneIDi 5367722.
KEGGi mmw:Mmwyl1_4235.
PATRICi 22472159. VBIMarSp124341_4391.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi MRMIAGH.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci MSP400668:GHKD-4338-MONOMER.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiPROB_MARMS
AccessioniPrimary (citable) accession number: A6W351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3