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A6W2P7

- BETB_MARMS

UniProt

A6W2P7 - BETB_MARMS

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene
betB, Mmwyl1_4080
Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1 By similarity
Metal bindingi24 – 241Potassium 1; via carbonyl oxygen By similarity
Metal bindingi90 – 901Potassium 1 By similarity
Active sitei159 – 1591Charge relay system By similarity
Binding sitei206 – 2061NAD/NADP; via amide nitrogen By similarity
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygen By similarity
Active sitei247 – 2471Proton acceptor By similarity
Binding sitei281 – 2811NAD/NADP By similarity
Binding sitei382 – 3821NAD/NADP By similarity
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygen By similarity
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygen By similarity
Active sitei459 – 4591Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADP By similarity
Nucleotide bindingi173 – 1764NAD/NADP By similarity
Nucleotide bindingi225 – 2306NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciMSP400668:GHKD-4177-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Mmwyl1_4080
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotationPRO_1000083709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi400668.Mmwyl1_4080.

Structurei

3D structure databases

ProteinModelPortaliA6W2P7.
SMRiA6W2P7. Positions 5-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCTDEMTI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6W2P7-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQQQYIHG RYHASTSGEH FETINPATGE VIATVEHAGQ AELDAAVESA    50
KQGQKVWSAM SPVERGRILK KAAELLRENN EELARLEVLD TGKPLQEAIV 100
VDIQTGADVI EYYAGLTDKI QGDYQDLGNG NFFYTRREPL GICAGIGAWN 150
YPIQIAMWKS GPALAAGNAM IFKPSEETPL TALKLAEIFT EAGLPDGVFN 200
VIQGDARTGQ LITNHPDIDK VSFTGEVGTG KKVMAASAQS LKQVTMELGG 250
KSPMIIFPDM PVDQAVSAAM LANFYTQGEV CTNGTRVFVH ADMLDAFTKE 300
LKQRTEAMII GDPMDMDTQV GALISKDHMQ KVLGYIQAAK DAGATLLCGG 350
YQVTENGLDK GAFVAPTVFT DCTDDMPQVR DEIFGPVMSV LSFTDEDEVI 400
ARANDTKLGL AAGVFTKDFA RAHRVINQLQ AGICWINSWG ASPAEMPVGG 450
YKQSGIGREN GIETLYHYTQ NKSVFVDLND IQSPY 485
Length:485
Mass (Da):52,554
Last modified:August 21, 2007 - v1
Checksum:i7232C7ABBD5185DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72976.1.
RefSeqiWP_012071741.1. NC_009654.1.
YP_001342911.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR72976; ABR72976; Mmwyl1_4080.
GeneIDi5366905.
KEGGimmw:Mmwyl1_4080.
PATRICi22471823. VBIMarSp124341_4229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72976.1 .
RefSeqi WP_012071741.1. NC_009654.1.
YP_001342911.1. NC_009654.1.

3D structure databases

ProteinModelPortali A6W2P7.
SMRi A6W2P7. Positions 5-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400668.Mmwyl1_4080.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR72976 ; ABR72976 ; Mmwyl1_4080 .
GeneIDi 5366905.
KEGGi mmw:Mmwyl1_4080.
PATRICi 22471823. VBIMarSp124341_4229.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CTDEMTI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci MSP400668:GHKD-4177-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiBETB_MARMS
AccessioniPrimary (citable) accession number: A6W2P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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