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A6W2P7 (BETB_MARMS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:Mmwyl1_4080
OrganismMarinomonas sp. (strain MWYL1) [Complete proteome] [HAMAP]
Taxonomic identifier400668 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity. HAMAP-Rule MF_00804

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Cofactor

Binds 2 potassium ions per subunit By similarity. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Subunit structure

Dimer of dimers By similarity. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandMetal-binding
NAD
NADP
Potassium
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485NAD/NADP-dependent betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000083709

Regions

Nucleotide binding147 – 1504NAD/NADP By similarity
Nucleotide binding173 – 1764NAD/NADP By similarity
Nucleotide binding225 – 2306NAD/NADP By similarity

Sites

Active site1591Charge relay system By similarity
Active site2471Proton acceptor By similarity
Active site4591Charge relay system By similarity
Metal binding231Potassium 1 By similarity
Metal binding241Potassium 1; via carbonyl oxygen By similarity
Metal binding901Potassium 1 By similarity
Metal binding2411Potassium 2; via carbonyl oxygen By similarity
Metal binding4521Potassium 2; via carbonyl oxygen By similarity
Metal binding4551Potassium 2; via carbonyl oxygen By similarity
Binding site2061NAD/NADP; via amide nitrogen By similarity
Binding site2811NAD/NADP By similarity
Binding site3821NAD/NADP By similarity

Amino acid modifications

Modified residue2811Cysteine sulfenic acid (-SOH) By similarity

Sequences

Sequence LengthMass (Da)Tools
A6W2P7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 7232C7ABBD5185DC

FASTA48552,554
        10         20         30         40         50         60 
MAHQQQYIHG RYHASTSGEH FETINPATGE VIATVEHAGQ AELDAAVESA KQGQKVWSAM 

        70         80         90        100        110        120 
SPVERGRILK KAAELLRENN EELARLEVLD TGKPLQEAIV VDIQTGADVI EYYAGLTDKI 

       130        140        150        160        170        180 
QGDYQDLGNG NFFYTRREPL GICAGIGAWN YPIQIAMWKS GPALAAGNAM IFKPSEETPL 

       190        200        210        220        230        240 
TALKLAEIFT EAGLPDGVFN VIQGDARTGQ LITNHPDIDK VSFTGEVGTG KKVMAASAQS 

       250        260        270        280        290        300 
LKQVTMELGG KSPMIIFPDM PVDQAVSAAM LANFYTQGEV CTNGTRVFVH ADMLDAFTKE 

       310        320        330        340        350        360 
LKQRTEAMII GDPMDMDTQV GALISKDHMQ KVLGYIQAAK DAGATLLCGG YQVTENGLDK 

       370        380        390        400        410        420 
GAFVAPTVFT DCTDDMPQVR DEIFGPVMSV LSFTDEDEVI ARANDTKLGL AAGVFTKDFA 

       430        440        450        460        470        480 
RAHRVINQLQ AGICWINSWG ASPAEMPVGG YKQSGIGREN GIETLYHYTQ NKSVFVDLND 


IQSPY 

« Hide

References

[1]"Complete sequence of Marinomonas sp. MWYL1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MWYL1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000749 Genomic DNA. Translation: ABR72976.1.
RefSeqYP_001342911.1. NC_009654.1.

3D structure databases

ProteinModelPortalA6W2P7.
SMRA6W2P7. Positions 5-485.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING400668.Mmwyl1_4080.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR72976; ABR72976; Mmwyl1_4080.
GeneID5366905.
KEGGmmw:Mmwyl1_4080.
PATRIC22471823. VBIMarSp124341_4229.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAHIMKQAA.
OrthoDBEOG6BS8QW.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycMSP400668:GHKD-4177-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_MARMS
AccessionPrimary (citable) accession number: A6W2P7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways