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A6W2P7

- BETB_MARMS

UniProt

A6W2P7 - BETB_MARMS

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Potassium 1UniRule annotation
    Metal bindingi24 – 241Potassium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi90 – 901Potassium 1UniRule annotation
    Active sitei159 – 1591Charge relay systemUniRule annotation
    Binding sitei206 – 2061NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei247 – 2471Proton acceptorUniRule annotation
    Binding sitei281 – 2811NAD/NADPUniRule annotation
    Binding sitei382 – 3821NAD/NADPUniRule annotation
    Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei459 – 4591Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
    Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
    Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciMSP400668:GHKD-4177-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:Mmwyl1_4080
    OrganismiMarinomonas sp. (strain MWYL1)
    Taxonomic identifieri400668 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
    ProteomesiUP000001113: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000083709Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi400668.Mmwyl1_4080.

    Structurei

    3D structure databases

    ProteinModelPortaliA6W2P7.
    SMRiA6W2P7. Positions 5-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiCTDEMTI.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6W2P7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHQQQYIHG RYHASTSGEH FETINPATGE VIATVEHAGQ AELDAAVESA    50
    KQGQKVWSAM SPVERGRILK KAAELLRENN EELARLEVLD TGKPLQEAIV 100
    VDIQTGADVI EYYAGLTDKI QGDYQDLGNG NFFYTRREPL GICAGIGAWN 150
    YPIQIAMWKS GPALAAGNAM IFKPSEETPL TALKLAEIFT EAGLPDGVFN 200
    VIQGDARTGQ LITNHPDIDK VSFTGEVGTG KKVMAASAQS LKQVTMELGG 250
    KSPMIIFPDM PVDQAVSAAM LANFYTQGEV CTNGTRVFVH ADMLDAFTKE 300
    LKQRTEAMII GDPMDMDTQV GALISKDHMQ KVLGYIQAAK DAGATLLCGG 350
    YQVTENGLDK GAFVAPTVFT DCTDDMPQVR DEIFGPVMSV LSFTDEDEVI 400
    ARANDTKLGL AAGVFTKDFA RAHRVINQLQ AGICWINSWG ASPAEMPVGG 450
    YKQSGIGREN GIETLYHYTQ NKSVFVDLND IQSPY 485
    Length:485
    Mass (Da):52,554
    Last modified:August 21, 2007 - v1
    Checksum:i7232C7ABBD5185DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72976.1.
    RefSeqiWP_012071741.1. NC_009654.1.
    YP_001342911.1. NC_009654.1.

    Genome annotation databases

    EnsemblBacteriaiABR72976; ABR72976; Mmwyl1_4080.
    GeneIDi5366905.
    KEGGimmw:Mmwyl1_4080.
    PATRICi22471823. VBIMarSp124341_4229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72976.1 .
    RefSeqi WP_012071741.1. NC_009654.1.
    YP_001342911.1. NC_009654.1.

    3D structure databases

    ProteinModelPortali A6W2P7.
    SMRi A6W2P7. Positions 5-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 400668.Mmwyl1_4080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR72976 ; ABR72976 ; Mmwyl1_4080 .
    GeneIDi 5366905.
    KEGGi mmw:Mmwyl1_4080.
    PATRICi 22471823. VBIMarSp124341_4229.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi CTDEMTI.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci MSP400668:GHKD-4177-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MWYL1.

    Entry informationi

    Entry nameiBETB_MARMS
    AccessioniPrimary (citable) accession number: A6W2P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3