Reviewed, UniProtKB/Swiss-Prot A6W2P7 (BETB_MARMS)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Mmwyl1_4080

Organism

Marinomonas sp. (strain MWYL1) [Complete proteome] [HAMAP]

Taxonomic identifier

400668 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Marinomonas

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Betaine aldehyde dehydrogenase		PRO_1000083709
Regions
	Nucleotide binding	225 – 230	6	NAD By similarity
Sites
	Active site	247	1	By similarity
	Active site	281	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6W2P7-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 7232C7ABBD5185DC	FASTA	485	52,554
	10 20 30 40 50 60 MAHQQQYIHG RYHASTSGEH FETINPATGE VIATVEHAGQ AELDAAVESA KQGQKVWSAM 70 80 90 100 110 120 SPVERGRILK KAAELLRENN EELARLEVLD TGKPLQEAIV VDIQTGADVI EYYAGLTDKI 130 140 150 160 170 180 QGDYQDLGNG NFFYTRREPL GICAGIGAWN YPIQIAMWKS GPALAAGNAM IFKPSEETPL 190 200 210 220 230 240 TALKLAEIFT EAGLPDGVFN VIQGDARTGQ LITNHPDIDK VSFTGEVGTG KKVMAASAQS 250 260 270 280 290 300 LKQVTMELGG KSPMIIFPDM PVDQAVSAAM LANFYTQGEV CTNGTRVFVH ADMLDAFTKE 310 320 330 340 350 360 LKQRTEAMII GDPMDMDTQV GALISKDHMQ KVLGYIQAAK DAGATLLCGG YQVTENGLDK 370 380 390 400 410 420 GAFVAPTVFT DCTDDMPQVR DEIFGPVMSV LSFTDEDEVI ARANDTKLGL AAGVFTKDFA 430 440 450 460 470 480 RAHRVINQLQ AGICWINSWG ASPAEMPVGG YKQSGIGREN GIETLYHYTQ NKSVFVDLND IQSPY

References

[1]

"Complete sequence of Marinomonas sp. MWYL1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000749 Genomic DNA. Translation: ABR72976.1.
RefSeq	YP_001342911.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5366905.
GenomeReviews	Gene locus Mmwyl1_4080 in contig CP000749_GR.
KEGG	mmw:Mmwyl1_4080.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016163. Ald_DHase_C. IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR011264. Betaine_Ald_DHase. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_MARMS

Accession

Primary (citable) accession number: A6W2P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	November 4, 2008
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)