Skip Header

Contribute Send feedback
Read comments (?) or add your own

A6W2P7 (BETB_MARMS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:Mmwyl1_4080
OrganismMarinomonas sp. (strain MWYL1) [Complete proteome] [HAMAP]
Taxonomic identifier400668 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Marinomonas

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000083709

Regions

Nucleotide binding225 – 2306NAD By similarity

Sites

Active site2471 By similarity
Active site2811 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6W2P7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 7232C7ABBD5185DC

FASTA48552,554
        10         20         30         40         50         60 
MAHQQQYIHG RYHASTSGEH FETINPATGE VIATVEHAGQ AELDAAVESA KQGQKVWSAM 

        70         80         90        100        110        120 
SPVERGRILK KAAELLRENN EELARLEVLD TGKPLQEAIV VDIQTGADVI EYYAGLTDKI 

       130        140        150        160        170        180 
QGDYQDLGNG NFFYTRREPL GICAGIGAWN YPIQIAMWKS GPALAAGNAM IFKPSEETPL 

       190        200        210        220        230        240 
TALKLAEIFT EAGLPDGVFN VIQGDARTGQ LITNHPDIDK VSFTGEVGTG KKVMAASAQS 

       250        260        270        280        290        300 
LKQVTMELGG KSPMIIFPDM PVDQAVSAAM LANFYTQGEV CTNGTRVFVH ADMLDAFTKE 

       310        320        330        340        350        360 
LKQRTEAMII GDPMDMDTQV GALISKDHMQ KVLGYIQAAK DAGATLLCGG YQVTENGLDK 

       370        380        390        400        410        420 
GAFVAPTVFT DCTDDMPQVR DEIFGPVMSV LSFTDEDEVI ARANDTKLGL AAGVFTKDFA 

       430        440        450        460        470        480 
RAHRVINQLQ AGICWINSWG ASPAEMPVGG YKQSGIGREN GIETLYHYTQ NKSVFVDLND 


IQSPY

« Hide

References

[1]"Complete sequence of Marinomonas sp. MWYL1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MWYL1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000749 Genomic DNA. Translation: ABR72976.1.
RefSeqYP_001342911.1. NC_009654.1.

3D structure databases

ProteinModelPortalA6W2P7.
SMRA6W2P7. Positions 5-485.
ModBaseSearch...

Protein-protein interaction databases

STRING400668.Mmwyl1_4080.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR72976; ABR72976; Mmwyl1_4080.
GeneID5366905.
KEGGmmw:Mmwyl1_4080.
PATRIC22471823. VBIMarSp124341_4229.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMASKEHESK.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycMSP400668:GHKD-4191-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_MARMS
AccessionPrimary (citable) accession number: A6W2P7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents