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A6W230

- APHA_MARMS

UniProt

A6W230 - APHA_MARMS

Protein

Class B acid phosphatase

Gene

aphA

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.By similarity

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.By similarity

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei70 – 701NucleophileBy similarity
    Metal bindingi70 – 701MagnesiumBy similarity
    Active sitei72 – 721Proton donorBy similarity
    Metal bindingi72 – 721Magnesium; via carbonyl oxygenBy similarity
    Binding sitei176 – 1761SubstrateBy similarity
    Metal bindingi191 – 1911MagnesiumBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMSP400668:GHKD-3951-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class B acid phosphataseBy similarity (EC:3.1.3.2ImportedBy similarity)
    Short name:
    CBAPBy similarity
    Gene namesi
    Name:aphABy similarity
    Ordered Locus Names:Mmwyl1_3860
    OrganismiMarinomonas sp. (strain MWYL1)
    Taxonomic identifieri400668 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
    ProteomesiUP000001113: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 236214Class B acid phosphataseSequence AnalysisPRO_5000259712Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi400668.Mmwyl1_3860.

    Structurei

    3D structure databases

    ProteinModelPortaliA6W230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni138 – 1392Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class B bacterial acid phosphatase family.By similarity

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3700.
    HOGENOMiHOG000270623.
    KOiK03788.
    OMAiSSRTEYT.
    OrthoDBiEOG6HTNVZ.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view]
    PfamiPF03767. Acid_phosphat_B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01672. AphA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6W230-1 [UniParc]FASTAAdd to Basket

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    MNHTLRSITL VLACVASLSA NADPKTPGTH KGYSTIDMTT AGMPADVKMI    50
    SVADIQKELQ GKAPFAVGFD IDDTTLFSTP VFYRGQQEFS PNGYSYLTNQ 100
    DFWDKANCGW DAFSMPKNIA KELIAMHQER GDSIYFITGR TGSDCNFTTE 150
    YLKKTFDIKD MHDVIFAGSS RTEYTKTKYI KNNDIKIYYG DADGDIISAR 200
    DAGAEGIRVM RAANSSYTPI PKNGIYGERV LKDSQY 236
    Length:236
    Mass (Da):26,223
    Last modified:August 21, 2007 - v1
    Checksum:i54217BA69A47D9D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72759.1.
    RefSeqiWP_012071524.1. NC_009654.1.
    YP_001342694.1. NC_009654.1.

    Genome annotation databases

    EnsemblBacteriaiABR72759; ABR72759; Mmwyl1_3860.
    GeneIDi5365221.
    KEGGimmw:Mmwyl1_3860.
    PATRICi22471343. VBIMarSp124341_3994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72759.1 .
    RefSeqi WP_012071524.1. NC_009654.1.
    YP_001342694.1. NC_009654.1.

    3D structure databases

    ProteinModelPortali A6W230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 400668.Mmwyl1_3860.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR72759 ; ABR72759 ; Mmwyl1_3860 .
    GeneIDi 5365221.
    KEGGi mmw:Mmwyl1_3860.
    PATRICi 22471343. VBIMarSp124341_3994.

    Phylogenomic databases

    eggNOGi COG3700.
    HOGENOMi HOG000270623.
    KOi K03788.
    OMAi SSRTEYT.
    OrthoDBi EOG6HTNVZ.

    Enzyme and pathway databases

    BioCyci MSP400668:GHKD-3951-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view ]
    Pfami PF03767. Acid_phosphat_B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01672. AphA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MWYL1.

    Entry informationi

    Entry nameiAPHA_MARMS
    AccessioniPrimary (citable) accession number: A6W230
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3