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A6W230

- APHA_MARMS

UniProt

A6W230 - APHA_MARMS

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Protein

Class B acid phosphatase

Gene

aphA

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701NucleophileBy similarity
Metal bindingi70 – 701MagnesiumBy similarity
Active sitei72 – 721Proton donorBy similarity
Metal bindingi72 – 721Magnesium; via carbonyl oxygenBy similarity
Binding sitei176 – 1761SubstrateBy similarity
Metal bindingi191 – 1911MagnesiumBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMSP400668:GHKD-3951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Class B acid phosphataseBy similarity (EC:3.1.3.2ImportedBy similarity)
Short name:
CBAPBy similarity
Gene namesi
Name:aphABy similarity
Ordered Locus Names:Mmwyl1_3860
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 236214Class B acid phosphataseSequence AnalysisPRO_5000259712Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3860.

Structurei

3D structure databases

ProteinModelPortaliA6W230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1392Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class B bacterial acid phosphatase family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3700.
HOGENOMiHOG000270623.
KOiK03788.
OMAiSSRTEYT.
OrthoDBiEOG6HTNVZ.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view]
PfamiPF03767. Acid_phosphat_B. 1 hit.
[Graphical view]
PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01672. AphA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6W230-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHTLRSITL VLACVASLSA NADPKTPGTH KGYSTIDMTT AGMPADVKMI
60 70 80 90 100
SVADIQKELQ GKAPFAVGFD IDDTTLFSTP VFYRGQQEFS PNGYSYLTNQ
110 120 130 140 150
DFWDKANCGW DAFSMPKNIA KELIAMHQER GDSIYFITGR TGSDCNFTTE
160 170 180 190 200
YLKKTFDIKD MHDVIFAGSS RTEYTKTKYI KNNDIKIYYG DADGDIISAR
210 220 230
DAGAEGIRVM RAANSSYTPI PKNGIYGERV LKDSQY
Length:236
Mass (Da):26,223
Last modified:August 21, 2007 - v1
Checksum:i54217BA69A47D9D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR72759.1.
RefSeqiWP_012071524.1. NC_009654.1.
YP_001342694.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR72759; ABR72759; Mmwyl1_3860.
GeneIDi5365221.
KEGGimmw:Mmwyl1_3860.
PATRICi22471343. VBIMarSp124341_3994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR72759.1 .
RefSeqi WP_012071524.1. NC_009654.1.
YP_001342694.1. NC_009654.1.

3D structure databases

ProteinModelPortali A6W230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400668.Mmwyl1_3860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR72759 ; ABR72759 ; Mmwyl1_3860 .
GeneIDi 5365221.
KEGGi mmw:Mmwyl1_3860.
PATRICi 22471343. VBIMarSp124341_3994.

Phylogenomic databases

eggNOGi COG3700.
HOGENOMi HOG000270623.
KOi K03788.
OMAi SSRTEYT.
OrthoDBi EOG6HTNVZ.

Enzyme and pathway databases

BioCyci MSP400668:GHKD-3951-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view ]
Pfami PF03767. Acid_phosphat_B. 1 hit.
[Graphical view ]
PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01672. AphA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiAPHA_MARMS
AccessioniPrimary (citable) accession number: A6W230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3