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A6W230

- APHA_MARMS

UniProt

A6W230 - APHA_MARMS

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Protein
Class B acid phosphatase
Gene
aphA, Mmwyl1_3860
Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Nucleophile By similarity
Metal bindingi70 – 701Magnesium By similarity
Active sitei72 – 721Proton donor By similarity
Metal bindingi72 – 721Magnesium; via carbonyl oxygen By similarity
Binding sitei176 – 1761Substrate By similarity
Metal bindingi191 – 1911Magnesium By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMSP400668:GHKD-3951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Class B acid phosphatase (EC:3.1.3.2)
Short name:
CBAP
Gene namesi
Name:aphA
Ordered Locus Names:Mmwyl1_3860
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 236214Class B acid phosphatase
PRO_5000259712Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3860.

Structurei

3D structure databases

ProteinModelPortaliA6W230.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1392Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3700.
HOGENOMiHOG000270623.
KOiK03788.
OMAiSSRTEYT.
OrthoDBiEOG6HTNVZ.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view]
PfamiPF03767. Acid_phosphat_B. 1 hit.
[Graphical view]
PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01672. AphA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6W230-1 [UniParc]FASTAAdd to Basket

« Hide

MNHTLRSITL VLACVASLSA NADPKTPGTH KGYSTIDMTT AGMPADVKMI    50
SVADIQKELQ GKAPFAVGFD IDDTTLFSTP VFYRGQQEFS PNGYSYLTNQ 100
DFWDKANCGW DAFSMPKNIA KELIAMHQER GDSIYFITGR TGSDCNFTTE 150
YLKKTFDIKD MHDVIFAGSS RTEYTKTKYI KNNDIKIYYG DADGDIISAR 200
DAGAEGIRVM RAANSSYTPI PKNGIYGERV LKDSQY 236
Length:236
Mass (Da):26,223
Last modified:August 21, 2007 - v1
Checksum:i54217BA69A47D9D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72759.1.
RefSeqiWP_012071524.1. NC_009654.1.
YP_001342694.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR72759; ABR72759; Mmwyl1_3860.
GeneIDi5365221.
KEGGimmw:Mmwyl1_3860.
PATRICi22471343. VBIMarSp124341_3994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72759.1 .
RefSeqi WP_012071524.1. NC_009654.1.
YP_001342694.1. NC_009654.1.

3D structure databases

ProteinModelPortali A6W230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400668.Mmwyl1_3860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR72759 ; ABR72759 ; Mmwyl1_3860 .
GeneIDi 5365221.
KEGGi mmw:Mmwyl1_3860.
PATRICi 22471343. VBIMarSp124341_3994.

Phylogenomic databases

eggNOGi COG3700.
HOGENOMi HOG000270623.
KOi K03788.
OMAi SSRTEYT.
OrthoDBi EOG6HTNVZ.

Enzyme and pathway databases

BioCyci MSP400668:GHKD-3951-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view ]
Pfami PF03767. Acid_phosphat_B. 1 hit.
[Graphical view ]
PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01672. AphA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiAPHA_MARMS
AccessioniPrimary (citable) accession number: A6W230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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