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A6W1X2

- ACDH_MARMS

UniProt

A6W1X2 - ACDH_MARMS

Protein

Acetaldehyde dehydrogenase

Gene

Mmwyl1_3802

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
    Binding sitei273 – 2731NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi162 – 1709NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciMSP400668:GHKD-3893-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:Mmwyl1_3802
    OrganismiMarinomonas sp. (strain MWYL1)
    Taxonomic identifieri400668 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
    ProteomesiUP000001113: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Acetaldehyde dehydrogenasePRO_0000387665Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi400668.Mmwyl1_3802.

    Structurei

    3D structure databases

    ProteinModelPortaliA6W1X2.
    SMRiA6W1X2. Positions 1-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiREVQKYV.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6W1X2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKKLRAVII GPGNIGTDLL IKMKRSDWIE PVWMVGIDPD SDGLKRARDM    50
    GIKTTHQGID DFIDYLIADD IRIAFDATSA YVHEENSRKL NALGVVMIDL 100
    TPAAIGPYCI PPVNLEEHAN NLEMNVNMVT CGGQATIPMV AAVSSVQKVD 150
    YAEIIATVSS RSVGPGTRAN IDEFTRTTAS AVEQIGGARK GKAIIVINPA 200
    EPPLMMRDTI HCLLSEDPDE VNISKSVYNM VKEVQKYVPG YRLVNGPIFD 250
    GRKVSIFMEV EGLGDFLPTY SGNLDIMTAA ALRTAEMFAE RVASKAITLP 300
    NRH 303
    Length:303
    Mass (Da):33,117
    Last modified:August 21, 2007 - v1
    Checksum:iECD4210DC23C6032
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72701.1.
    RefSeqiWP_012071466.1. NC_009654.1.
    YP_001342636.1. NC_009654.1.

    Genome annotation databases

    EnsemblBacteriaiABR72701; ABR72701; Mmwyl1_3802.
    GeneIDi5367910.
    KEGGimmw:Mmwyl1_3802.
    PATRICi22471227. VBIMarSp124341_3936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72701.1 .
    RefSeqi WP_012071466.1. NC_009654.1.
    YP_001342636.1. NC_009654.1.

    3D structure databases

    ProteinModelPortali A6W1X2.
    SMRi A6W1X2. Positions 1-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 400668.Mmwyl1_3802.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR72701 ; ABR72701 ; Mmwyl1_3802 .
    GeneIDi 5367910.
    KEGGi mmw:Mmwyl1_3802.
    PATRICi 22471227. VBIMarSp124341_3936.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi REVQKYV.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci MSP400668:GHKD-3893-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MWYL1.

    Entry informationi

    Entry nameiACDH_MARMS
    AccessioniPrimary (citable) accession number: A6W1X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3