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A6W1X2

- ACDH_MARMS

UniProt

A6W1X2 - ACDH_MARMS

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Protein

Acetaldehyde dehydrogenase

Gene

Mmwyl1_3802

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
Binding sitei273 – 2731NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1709NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMSP400668:GHKD-3893-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Mmwyl1_3802
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Acetaldehyde dehydrogenasePRO_0000387665Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3802.

Structurei

3D structure databases

ProteinModelPortaliA6W1X2.
SMRiA6W1X2. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiREVQKYV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A6W1X2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKKLRAVII GPGNIGTDLL IKMKRSDWIE PVWMVGIDPD SDGLKRARDM
60 70 80 90 100
GIKTTHQGID DFIDYLIADD IRIAFDATSA YVHEENSRKL NALGVVMIDL
110 120 130 140 150
TPAAIGPYCI PPVNLEEHAN NLEMNVNMVT CGGQATIPMV AAVSSVQKVD
160 170 180 190 200
YAEIIATVSS RSVGPGTRAN IDEFTRTTAS AVEQIGGARK GKAIIVINPA
210 220 230 240 250
EPPLMMRDTI HCLLSEDPDE VNISKSVYNM VKEVQKYVPG YRLVNGPIFD
260 270 280 290 300
GRKVSIFMEV EGLGDFLPTY SGNLDIMTAA ALRTAEMFAE RVASKAITLP

NRH
Length:303
Mass (Da):33,117
Last modified:August 21, 2007 - v1
Checksum:iECD4210DC23C6032
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72701.1.
RefSeqiWP_012071466.1. NC_009654.1.
YP_001342636.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR72701; ABR72701; Mmwyl1_3802.
GeneIDi5367910.
KEGGimmw:Mmwyl1_3802.
PATRICi22471227. VBIMarSp124341_3936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72701.1 .
RefSeqi WP_012071466.1. NC_009654.1.
YP_001342636.1. NC_009654.1.

3D structure databases

ProteinModelPortali A6W1X2.
SMRi A6W1X2. Positions 1-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400668.Mmwyl1_3802.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR72701 ; ABR72701 ; Mmwyl1_3802 .
GeneIDi 5367910.
KEGGi mmw:Mmwyl1_3802.
PATRICi 22471227. VBIMarSp124341_3936.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi REVQKYV.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci MSP400668:GHKD-3893-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiACDH_MARMS
AccessioniPrimary (citable) accession number: A6W1X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3