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A6W1X2

- ACDH_MARMS

UniProt

A6W1X2 - ACDH_MARMS

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Protein
Acetaldehyde dehydrogenase
Gene
Mmwyl1_3802
Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Acyl-thioester intermediate By similarity
Binding sitei273 – 2731NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1709NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMSP400668:GHKD-3893-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Ordered Locus Names:Mmwyl1_3802
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Acetaldehyde dehydrogenaseUniRule annotation
PRO_0000387665Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3802.

Structurei

3D structure databases

ProteinModelPortaliA6W1X2.
SMRiA6W1X2. Positions 1-294.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiREVQKYV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A6W1X2-1 [UniParc]FASTAAdd to Basket

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MRKKLRAVII GPGNIGTDLL IKMKRSDWIE PVWMVGIDPD SDGLKRARDM    50
GIKTTHQGID DFIDYLIADD IRIAFDATSA YVHEENSRKL NALGVVMIDL 100
TPAAIGPYCI PPVNLEEHAN NLEMNVNMVT CGGQATIPMV AAVSSVQKVD 150
YAEIIATVSS RSVGPGTRAN IDEFTRTTAS AVEQIGGARK GKAIIVINPA 200
EPPLMMRDTI HCLLSEDPDE VNISKSVYNM VKEVQKYVPG YRLVNGPIFD 250
GRKVSIFMEV EGLGDFLPTY SGNLDIMTAA ALRTAEMFAE RVASKAITLP 300
NRH 303
Length:303
Mass (Da):33,117
Last modified:August 21, 2007 - v1
Checksum:iECD4210DC23C6032
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72701.1.
RefSeqiWP_012071466.1. NC_009654.1.
YP_001342636.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR72701; ABR72701; Mmwyl1_3802.
GeneIDi5367910.
KEGGimmw:Mmwyl1_3802.
PATRICi22471227. VBIMarSp124341_3936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR72701.1 .
RefSeqi WP_012071466.1. NC_009654.1.
YP_001342636.1. NC_009654.1.

3D structure databases

ProteinModelPortali A6W1X2.
SMRi A6W1X2. Positions 1-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400668.Mmwyl1_3802.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR72701 ; ABR72701 ; Mmwyl1_3802 .
GeneIDi 5367910.
KEGGi mmw:Mmwyl1_3802.
PATRICi 22471227. VBIMarSp124341_3936.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi REVQKYV.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci MSP400668:GHKD-3893-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiACDH_MARMS
AccessioniPrimary (citable) accession number: A6W1X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi